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| 1 | On the cell biology of pit cells,the liver-specific NK cells显示文摘INTRODUCTION Natural killer (NK) cells are functionally defined by their ability to kill certain tumor cells and virus-infected cells without prior | Luo DZ Vermijlen D Ahishali B Triantis V Plakoutsi G Braet F Vanderkerken K Wisse E | 2000 | World Journal of Gastroenterology2000，6，1： | 8 |
| 2 | Participation of CD45,NKR-P1A and ANK61 antigen in rat hepatic NK cell(pit cell)-mediated target cell cytotoxicity显示文摘AIM Several triggering receptors have beendescribed to be involved in natural killer(NK)cell-mediated target cytotoxicity.In these studies,NKcells derived from blood or spleen were used.Pitcells are liver-specific NK cells that possess ahigher level of natural cytotoxicity and a differentmorphology when compared to blood NK cells.The aim of this study was to characterize the roleof the NK-triggering molecules NKR-P1A,ANK61antigen,and CD45 in pit cell-mediated killing oftarget cells.METHODS 51Cr-release and DNA fragmentationwere used to quantify target cell lysis andapoptosis,respectively.RESULTS Flow cytometric analysis showed thatpit cells expressed CD45,NKR-P1A,and ANK61antigen.Treatment of pit cells with monoclonalantibody(mAb)to CD45(ANK74)not onlyinhibited CC531s or YAC-1 target lysis but alsoapoptosis induced by pit cells.The mAbs to NKR-P1A(3.2.3)and ANK61 antigen(ANK61)had no effect on pit cell-mediated CC531s or YAC-1 targetcytolysis or apoptosis,while they did increase theFcγ receptor positive(FcγR+)P815 cytolysis andapoptosis.This enhanced cytotoxicity could beinhibited by 3,4-dichloroisocoumarin,an inhibitorof granzymes.CONCLUSION These results indicate that CD45participates in pit cell-mediated CC531s and YAC-1target cytolysis and apoptosis.NKR-P1A andANK61 antigen on pit cells function as activationstructures against FcγR+ P815 cells,which wasmediated by the perforin/granzyme pathway. | David Vermiilen Bülent Ahishali Vasilis Triantis Karin Vanderkerken Peter J. K.Kuppen Eddie Wisse | 2000 | World Journal of Gastroenterology2000，6，4： | 4 |
| 3 | Assessment of permeability in barrier type of endothelium in brain using tracers: Evans blue, sodium fluorescein, and horseradish peroxidase显示文摘 | Kaya M Ahishali B | 2011 | Methods Mol Biol2011，763，： | 1 |
| 4 | A case of Aeromonas hydrophila enteritis in the course of ulcerative colitis显示文摘 | Ahishali E Pinarbasi B Akyuz F | 2007 | European Journal of Internal Medicine2007，18，： | 1 |
| 5 | Evaluation of ultrastructural changes in paranasal sinus mucosa after functional endoscopic sinus surgery in patients with chronic rhinosinusitis显示文摘 | Keles N Ahishali B Ilicali OC | 2001 | Am J Rinol2001，15，4： | 1 |
| 6 | Response to hepatitis B vaccination in patients with celiac disease 显示文摘 | Ahishali E Boztas G Akyuz F Ibrisim D Poturoglu S Pinarbasi B Ozdil S Mungan Z | 2008 | Dig Dis Sci2008，53，8： | 1 |
| 7 | Effects oflipopolysaccharide on the blood brain barrier permeabilityin prolonged nitric oxide blockade -induced hypertensiverats显示文摘 | Ahishali B Kaya M Kalayci R | | Int J Neurosci0，115，2： | 1 |
| 8 | Evaluation of ultrastructual Changes in paranasal sinus mucosa after functional endoscopic sinus surgery in patients with chronic rhinosinusitis显示文摘 | Ahishali B Llicali OC | 2001 | Am J Rhinol2001，15，： | 1 |
| 9 | MHC class 1 expression protects colon carcinoma cells from cytolysis by hepatic NK (pit) cells by blooking the performing/granzyme pathway显示文摘 | Luo D Vemijlen D Ahishali B | 2002 | Comparative Hepatocology2002，1，： | 1 |
| 10 | MHC class I expression protects colon carcinoma cells from cytolysis and apoptosis by hepatic NK (pit) cells by blocking the perforin/granzyme pathway显示文摘 | Luo D Vermijlen D Ahishali B | 2002 | Comparative Hepatology2002，1，： | 1 |
| 11 | Assessment of permeability in barrier type of endothelium in brain using tracers: Evans blue, sodium fluorescein, and horseradish peroxidase显示文摘 | Kaya M Ahishali B | 2011 | Methods Mol Biol2011，763，： | 1 |
| 12 | Evaluation of ultrastructural changes in paranasal sinus mucosa after functional endoscopic sinus surgery in patients with chronic rhinosinusitis显示文摘 | Keles N Ahishali B Ilicali OC | 2001 | Am J Rinol2001，15，4： | 1 |
| 13 | Response to Hepatitis B Vaccination in Patients with Celiac Disease显示文摘 | Emel Ahishali Gungor Boztas Filiz Akyuz Duygu Ibrisim Sule Poturoglu Binnur Pinarbasi Sadakat Ozdil Zeynel Mungan | 2008 | Digestive Diseases and Sciences2008，，8： | 1 |
| 14 | MHC class Ⅰ expression protects rat colon carcinoma cells from hepatic natural killer cell-mediated apoptosis and cytolysis, by blocking the perforin/granzyme pathway显示文摘 | Luo D Vermijlen D Ahishali B | 2002 | Comparative Hepatology2002，1，1： | 1 |
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