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| 1 | Heterostructures in two-dimensional colloidal metal chalcogenides:Synthetic fundamentals and applications显示文摘As a new class of two-dimensional materials, two-dimensional (2D) heterostructures constructed from metal chalcogenides (MCs) have been gaining tremendous attention due to their unprecedented physical and chemical phenomena, mainly originated from their distinct structural features such as composition, architecture type, spatial arrangement of each component, crystal structure, exposed facet and interface, dimensionality in their heterostructures. Towards the realization of practical applications, synthetic approaches need a rational design with a variety of architecture types including laterally-combined, vertically-aligned, and conformally-coated 2D MC heterostructures. Among various synthetic routes, solution-based synthesis is thought of as an alternative to fabrication through high-cost setups since it can control those structural features in a cheap fashion. This review presents recent progress on solution-based synthesis to produce various 2D MC heterostructures with a focus on the synthetic fundamentals in terms of thermodynamic and kinetic aspects related to the growth mechanism. Four different synthetic approaches are reviewed: seeded growth, cation exchange reaction, colloidal atomic layer deposition, direct synthesis including one-step process and modified electrochemical method. We also provide some representative applications of 2D MC heterostructures and their hybrid composites in various fields including optoelectronics, thermoelectrics, catalysis, and battery. Finally, we offer an insight into challenges and future directions in a synthetic improvement of 2D MC heterostructures. | Yuho Min Eunmi Im Geon-Tae Hwang Jong-Woo Kim Cheol-Woo Ahn Jong-Jin Choi Byung-Dong Hahn Joon-Hwan Choi Woon-Ha Yoon Dong-Soo Park Dong Choon Hyun Geon Dae Moon | 2019 | Nano Research2019，12，8： | 6 |
| 2 | 来自一项艾日布林联合吉西他滨对比紫杉醇联合吉西他滨作为HER2阴性转移性乳腺癌的一线化疗的Ⅱ期、多中心、随机试验的包含神经病变相关量表的生活质量结果:韩国癌症研究组试验(KCSG BR13-11)显示文摘背景与目的一项比较艾日布林联合吉西他滨(eribulin plus gemcitabine,EG)或紫杉醇联合吉西他滨(paclitaxel plus gemcitabine,PG)作为转移性乳腺癌(metastatic breast cancer,MBC)患者一线化疗方案的II期临床试验发现,EG方案的神经毒性较低,但疗效与PG方案相似。在本研究中,我们分析了该临床实验中的癌症患者生命质量测评量表–紫杉烷(functional assessment of cancer therapy-taxane,FACT-Taxane)问卷评分以确定他们的生活质量(quality of life,QoL)。方法使用韩国版的FACT-Taxane问卷评估QoL。在评估基线之后,前12个疗程中每2个疗程评估1次QoL,之后每3个疗程评估1次QoL。使用线性混合模型评估EG组和PG组QoL的差异。结果在118例入组患者中,117例在基线时回复了FACT-Taxane问卷,PG组中有1例患者没有回复。EG组和PG组之间的基线QoL评分没有差异。在治疗期间,除了第11个疗程外,在第2–13个化疗疗程后,PG组紫杉烷亚量表评分显著高于EG组(均P<0.05)。神经病变特异性分析显示PG组患者的神经病症状比EG组患者更早出现且更严重(P<0.001)。结论在我们的QoL分析中,与PG方案相比,EG方案延迟并减少神经病变的发生。因此,艾日布林是MBC一线化疗药物紫杉醇的合理替代品。 | Ji‑Yeon Kim Seri Park Seock‑Ah Im Sung‑Bae Kim Joohyuk Sohn Keun Seok Lee Yee Soo Chae Ki Hyeong Lee Jee Hyun Kim Young‑Hyuck Im Tae‑Yong Kim Kyung‑Hun Lee Jin‑Hee Ahn Gun Min Kim In Hae Park Soo Jung Lee Hye Sook Han Se Hyun Kim Kyung Hae Jung Yeon Hee Park Korean Cancer Study Group | 2019 | 癌症2019，38，8： | 2 |
| 3 | Ameliorating liver fibrosis in an animal model using the secretome released from miR-122-transfected adipose-derived stem cells显示文摘BACKGROUND Recently,the exclusive use of mesenchymal stem cell(MSC)-secreted molecules,called secretome,rather than cells,has been evaluated for overcoming the limitations of cell-based therapy,while maintaining its advantages.However,the use of na?ve secretome may not fully satisfy the specificity of each disease.Therefore,it appears to be more advantageous to use the functionally reinforced secretome through a series of processes involving physico-chemical adjustments or genetic manipulation rather than to the use na?ve secretome.AIM To determine the therapeutic potential of the secretome released from miR-122-transfected adipose-derived stromal cells(ASCs).METHODS We collected secretory materials released from ASCs that had been transfected with antifibrotic miR-122(MCM)and compared their antifibrotic effects with those of the na?ve secretome(CM).MCM and CM were intravenously administered to the mouse model of thioacetamide-induced liver fibrosis,and their therapeutic potentials were compared.RESULTS MCM infusion provided higher therapeutic potential in terms of:(A)Reducing collagen content in the liver;(B)Inhibiting proinflammatory cytokines;and(C)Reducing abnormally elevated liver enzymes than the infusion of the na?ve secretome.The proteomic analysis of MCM also indicated that the contents of antifibrotic proteins were significantly elevated compared to those in the na?ve secretome.CONCLUSION We could,thus,conclude that the secretome released from miR-122-transfected ASCs has higher antifibrotic and anti-inflammatory properties than the na?ve secretome.Because miR-122 transfection into ASCs provides a specific way of potentiating the antifibrotic properties of ASC secretome,it could be considered as an enhanced method for reinforcing secretome effectiveness. | Kee-Hwan Kim Jae Im Lee Ok-Hee Kim Ha-Eun Hong Bong Jun Kwak Ho Joong Choi Joseph Ahn Tae Yun Lee Sang Chul Lee Say-June Kim | 2019 | World Journal of Stem Cells2019，11，11： | 2 |
| 4 | Effectiveness of percutaneous ethanol injection therapy in benign nodular and cystic thyroid diseases: long-term follow-up experience显示文摘 | Lee SJ Ahn IM | 2005 | Endocr J2005，52，4： | 1 |
| 5 | Sensitivity of plasma membrane H ^+-ATpase of cucumber root system in response to low root temperature 显示文摘 | Ahn S J Im Y Chung G C | 2000 | Plant Cell Report2000，19，： | 1 |
| 6 | Korea National Survey for Environmental Pollutants in the human body 2008: 1-hyd roxypyrene, 2-naphthol, and cotinine in urine of the Korean population 显示文摘 | Sul D Ahn R Im H | 2012 | Environ Res2012，118，： | 1 |
| 7 | Differential impact of low temperature on fatty acid unsaturation and lipoxygenase activity in fig leaf gourd and cucumber roots 显示文摘 | Lee S H Ahn S J Im Y J | 2005 | Biochemical and Biophysical Research Communications2005，330，： | 1 |
| 8 | Liver Glucokinase Can Be Activated by Peroxisome Proliferator-Activated Receptor-γ显示文摘 | So-youn Kim Ha-il Kim Sang-Kyu Park Seung-soon Im Tianzhu Li Hyae Gyeong Cheon and Yong-ho Ahn | 2004 | DIABETES2004，，： | 1 |
| 9 | Physiological responses of grafted-cucumber leaves and rootstock roots affected by low root temperature显示文摘 | Ahn S J Im Y J Chung G C | 1999 | Sci Hort1999，81，： | 1 |
| 10 | Laser surface hardening of S45C medium carbon steel using Nd:YAG laser with a continuous wave显示文摘 | SHIN H J YOO Y T AHN D G IM K | 2007 | Journal of Materials Processing Technology2007，，： | 1 |
| 11 | Glucose-stimulated upregulation of GLUT2 gene is mediated by sterol response element-binding protein-1c in the hepatocytes显示文摘 | Im SS Kang SY Ahn YH | | 0，，06： | 1 |
| 12 | One-year open-label study of entacapone in patients with advanced Parkinson disease显示文摘 | Ahn TB Im JH Lee MC | 2007 | Clin Neurol2007，3，2： | 1 |
| 13 | Extranodal nasal type NK/T-cell Lymphoma: Elucidating clinical prognostic factors for risk-based stratification of therapy显示文摘 | Jeeyun Lee Yeon Hee Park Won Seog Kim Seung-Sook Lee Baek-Yeol Ryoo Sung Hyun Yang Keon Woo Park Jung Hoon Kang Joon Oh Park Se Hoon Lee Kihyun Kim Chul Won Jung Young Suk Park Young-Hyuck Im Won Ki Kang Mark H. Lee Young H. Ko Yong Chan Ahn Keunchil Park | 2005 | European Journal of Cancer2005，，10： | 1 |
| 14 | Interface engineering of highly efficient perovskite solar cel ls 显示文摘 | Heo J H Han H J Kim D Ahn T K Im S H | 2015 | Energy Environ Sci2015，8，： | 1 |
| 15 | Human umbilical cord blood-derived mesenchymal stem cell transplantation at- tenuates severe brain injury by permanent middle cerebral artery occlusion in newborn rats显示文摘 | Kim ES Ahn SY Im GH | 2012 | Pediatr Res2012，72，3： | 1 |
| 16 | Quality of life outcomes including neuropathy-associated scale from a phase II,multicenter,randomized trial of eribulin plus gemcitabine versus paclitaxel plus gemcitabine as first-line chemotherapy for HER2-negative metastatic breast cancer:Korean Cancer Study Group Trial(KCSG BR13-11)显示文摘Background: A phase II clinical trial of the comparison between eribulin plus gemcitabine (EG) and paclitaxel plus gemcitabine (PG) as first-line chemotherapy for patients with metastatic breast cancer (MBC) found that the EG regimen was less neurotoxic, but was similar in efficacy to the PG regimen. In the present study, we analyzed functional assessment of cancer therapy-taxane (FACT-Taxane) questionnaires from patients in this clinical trial to determine their quality of life (QoL). Methods: QoL was assessed using the Korean version of the FACT-Taxane questionnaires. After baseline assessment, QoL was assessed every 2 cycles for 12 cycles and every 3 cycles thereafter. The linear mixed model was used to evaluate the difference in QoL between the EG and PG arms. Results: Of the 118 enrolled patients, 117 responded to the FACT-Taxane questionnaires at baseline, 1 in the PG arm did not. Baseline QoL scores were not different between the EG and PG arms. During treatment, taxane subscale scores were significantly higher in the PG arm than in the EG arm after 2-13 cycles of chemotherapy (all P < 0.05), except for the 11th cycle. Neuropathy-specific analysis showed that patients in the PG arm had earlier and more severe neuropathic symptoms than those in the EG arm (P < 0.001). Conclusions: In our QoL analysis, the EG regimen delayed and decreased neuropathy as compared with the PG regimen. Therefore, eribulin would be a reasonable substitute for paclitaxel as first-line chemotherapy for MBC. | Ji-Yeon Kim Seri Park Seock-Ah Im Sung-Bae Kim Joohyuk Sohn Keun Seok Lee Yee Soo Chae Ki Hyeong Lee Jee Hyun Kim Young-Hyuck Im Tae-Yong Kim Kyung-Hun Lee Jin-Hee Ahn Gun Min Kim In Hae Park Soo Jung Lee Hye Sook Han Se Hyun Kim Kyung Hae Jung Yeon Hee Park Korean Cancer Study Group | 2019 | Cancer Communications2019，39，1： | 1 |
| 17 | Growth inhibition and chemosensitivity of poorly differentiated human thyroid cancer cell line (NPA) transfected with p53 gene显示文摘 | Kim SB Ahn IM Park HJ | 2001 | Head Neck2001，23，3： | 1 |
| 18 | Effect of myopia on the thickness of the retinal nerve fiber layer measured by Cirrus HD optical coherence tomography 显示文摘 | Kang SH Hong SW Im SK Lee SH Ahn MD | 2010 | Invest Ophthal- mol V/s Sc/2010，51，8： | 1 |
| 19 | Outcome and predictors of mortality in patients requiring invasive mechanical ventilation due to acute respiratory failure while undergoing ambulatory chemotherapy for solid cancers显示文摘 | So Young Park So Yeon Lim Sang-Won Um Won-Jung Koh Man Pyo Chung Hojoong Kim O Jung Kwon Hye Kyeong Park Seok Jin Kim Young Hyuck Im Myung-Ju Ahn Gee Young Suh | 2013 | Supportive Care in Cancer2013，，6： | 1 |
| 20 | Differential impact of low temperature on fatty acid unsaturation and lipoxyge- nase activity in figleaf gourd and cucumber roots显示文摘 | Lee S H Ahn S J Im Y J | 2005 | Bi- ochemical and Biophysical Research Communications2005，330，4： | 1 |
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