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| 1 | Emerging blood-based biomarkers for detection of gastric cancer显示文摘Early detection and efficient monitoring of tumor dynamics are prerequisites for reducing disease burden and mortality, and for improving the management of patients with gastric cancer(GC). Blood-based biomarker assays for the detection of early-stage GC could be of great relevance both for population-wide or risk groupbased screening programs, while circulating biomarkers that reflect the genetic make-up and dynamics of the tumor would allow monitoring of treatment efficacy, predict recurrences and assess the genetic heterogeneity of the tumor. Recent research to identify blood-based biomarkers of GC has resulted in the identification of a wide variety of cancer-associated molecules, including various proteins, autoantibodies against tumor associated antigens, cell-free DNA fragments, m RNAs and various non-coding RNAs, circulating tumor cells and cancer-derived extracellular vesicles. Each type of these biomarkers provides different information on the disease status, has different advantages and disadvantages, and distinct clinical usefulness. In the current review, we summarize the recent developments in blood-based GC biomarker discovery, discuss the origin of various types of biomarkers and their clinical usefulness and the technological challenges in the development of biomarker assays for clinical use. | Zane Kalnina Irēna Meistere Ilze Kikuste Ivars Tolmanis Pawel Zayakin Aija Linē | 2015 | World Journal of Gastroenterology2015，21，41： | 7 |
| 2 | Targeted Resequencing Reveals ALK Fusions in Non-Small Cell Lung Carcinomas Detected by FISH, Immunohistochemistry, and Real-Time RT-PCR: A Comparison of Four Methods显示文摘 | Katja Tuononen Virinder Kaur Sarhadi Aino Wirtanen Mikko R?nty Kaisa Salmenkivi Aija Knuuttila Satu Remes Aino I. Telaranta-Keerie Stuart Bloor Pekka Ellonen Sakari Knuutila Akanchha Kesari | 2013 | BioMed Research International2013，，： | 1 |
| 3 | The benefits of R&D and breadth in in- novation strategies: a comparison of finnish service and manufacturing firms显示文摘 | LEIPONEN AIJA | 2012 | Industrial and Corporate Change2012，21，5： | 1 |
| 4 | Organization of knowledge exchange: an empirical study of knowledge-intensive business service relationships 显示文摘 | Aija Leiponen | 2006 | Economics of Innovation & New Technology2006，4，15： | 1 |
| 5 | Managing knowledge for innovation: the case of business - to - business services 显示文摘 | Leiponen Aija | 2006 | The Journal of Product Innovation Management2006，23，3： | 1 |
| 6 | Cervical cancer screening in primary health care setting in Sudan: a comparative study of visual inspection with acetic acid and Pap smear Int 显示文摘 | Ahmed Ibrahim Aija R Aro Vibeke Rasch | 2012 | Womens Health2012，4，： | 1 |
| 7 | What Exactly are Technological Regimes? Intra-industry Heterogeneity in the Organization of Innova- tion Activities显示文摘 | Aija Leiponen Ina Drejer | 2007 | Research Policy2007，36，8： | 1 |
| 8 | The benefits of R&D and breadth in in- novation strategies : A comparison of Finnish service and manufacturing firms 显示文摘 | Aija Leiponen | 2012 | Industrial&Corporate Change2012，21，5： | 1 |
| 9 | Skills and innovation显示文摘 | Aija Leiponen | 2005 | International Journal of Industrial Organization2005，，5： | 1 |
| 10 | Effects of elevated CO2 and temperature on secondary compounds in the needles of Scots pine (Pinus sylvestris L.)显示文摘 | Tommi R?is?nen Aija Ryypp? Riitta Julkunen-Tiitto Seppo Kellom?ki | 2008 | Trees2008，，1： | 1 |
| 11 | Cell‐free microRNAs as diagnostic, prognostic, and predictive biomarkers for lung cancer显示文摘 | Elīna Zandberga Viktors Kozirovskis Artūrs ābols Diāna Andrējeva Gunta Purkalne Aija Linē | 2012 | Genes Chromosom Cancer2012，，4： | 1 |
| 12 | Competing through Cooperation:The Or-ganization of Standard Setting in Wireless Telecommunica-tions显示文摘 | Aija Leiponen | 2008 | Management Science2008，，11： | 1 |
| 13 | ldentifieation of Metastasis Associated Antigen 1 (MTA1) by Serological Screening of Prostale Cancer cDNA Libraries显示文摘 | Geng L Deepak P A Aija L | 2008 | Open Biochem J2008，2，： | 1 |
| 14 | The benefits of R&D and breadth in in- novation strategies: a comparison of finnish service and manufacturing firms显示文摘 | LEIPONEN AIJA | 2012 | Industrial and Corporate Change2012，21，5： | 1 |
| 15 | Transfer of clonidine and dexmedetonfidine aeioss the isolated pefused hunmn plaeenta 显示文摘 | Aija Kokko T I Pienimaki P Lampela E | 1997 | Acta Anaesthesiol Scand1997，41，2： | 1 |
| 16 | Use of ICT Teaching-Learning Methods Make School Math Blossom 显示文摘 | Aija Cunska Inga Savicka | 2012 | Social and Behavioral Sciences2012，，69： | 1 |
| 17 | If you cannot block, you better run: Small finns, cooperative innovation and ppropriation strategies显示文摘 | Aija Leiponen Justin Byma | 2009 | Research Policy2009，，： | 1 |
| 18 | Identification of tumour antigens by serological analysis of cDNA expression cloning显示文摘 | Geng Li Amanda Miles Aija Line Robert C Rees | 2004 | Cancer Immunology Immunotherapy2004，，3： | 1 |
| 19 | If You Cannot Block, You Better Run: Small Firms, Cooperative Innovation, and Appro- priation strategies 显示文摘 | Aija Leiponen Justin Byma | 2009 | Research Policy2009，，9： | 1 |
| 20 | The relation between growth cessation and frost hardening in Scots pines of different origins 显示文摘 | Tapani Repo Gang Zhang Aija Ryyppoe | 2000 | Trees2000，14，8： | 1 |
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