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| 1 | Effect of Plaque Composition on Biomechanical Performance of a Carotid Stent: Computational Study显示文摘Clinical application of bare metal stents is constrained by the occurrence of instent restenosis,mainly due to the complex biomechanical environment in the body.Numerical simulation method was used to evaluate the effect of plaque composition on stent performance in a carotid artery.CT angiography(CTA)data were used as a reference,and zero-load state of the carotid artery was used to establish a 3D stenotic artery model.Different plaque compositions,calcified and hypo-cellular were defined in Model 1 and Model 2,respectively.Interactions between the stents and arterial tissues within the stent crimping-expansion process were analyzed to explore the effects of plaque composition on the mechanical parameters of carotid stents.Goodman diagram and fatigue safety factor(FSF)were analyzed to explore the effects of plaque composition on fatigue performance of a carotid stent in the stent service process.In the stent crimping-expansion process,the von Mises stress in the stent and the dog-boning ratio in Model 1 were higher than that in Model 2.The calcified plaque prevented the stent from expanding the stenotic vessel to a pre-set diameter.Thus,the risk of rupture in the calcified plaque was higher than that in the hypo-cellular plaque.Plaque also affected the stress/strain in the vessel wall,which was observed to be lower in Model 1 than in Model 2.This indicated that calcified plaque could decrease the stress-induced injury of arterial tissues.Within the stent service process,the stents used in these two models were predicted to not fail under fatigue rupture as calculated by the Goodman diagram.Additionally,the points closer to the fatigue limit were generally observed at the inner bend of the stent crowns.The FSF of the stent in Model 1 was lower than that in Model 2.The stent operating in the presence of calcified plaques suffered high risk of fractures.Reliability and fatigue performance of the stent were found to be associated with plaque composition.Hence,this study may provide stent designers an approach toward enhancing the mechanical reliability of a stent. | Xinyang Cui Qingshuai Ren Zihao Li Kun Peng Gaoyang Li ZhaoyongGu Aike Qiao | 2018 | Computer Modeling in Engineering & Sciences2018，，9： | 3 |
| 2 | NONLINEAR MOTION MECHANICS MODEL OF CURVED BLOOD VESSEL显示文摘A geometric model of curved blood vessels is established based on some reason-able hypotheses;the nonlinear motion mechanics model of the curved blood vessel is establishedaccording to basic mechanics laws.This model includes much more physiological factors.It cou-ples the interaction of blood flow with mechanical factors such as the displacement,deformation,strain and stress etc.of the curved blood vessel.It is of great importance for investigating thecirculation rules of the cardiovascular system and the nonlinear pulse wave propagation in curvedblood vessels. | Qiao Aike Liu Youjun Wu Shigui Xu Xiaohu Zeng Yanjun | 2003 | Acta Mechanica Solida Sinica2003，16，1： | 3 |
| 3 | Wall Shear Stresses in Small and Large 2-way Bypass Grafts显示文摘 | Aike Qiao Youjun Liu Zhihong Guo | 2006 | Med Eng Phys2006，28，3： | 1 |
| 4 | Medical application oriented blood flow simulation显示文摘 | Qiao Aike Liu Youjun | | 0，，01： | 1 |
| 5 | Influence of GraIt-Host Diameter Ratio on the Hemodynamics of CABG显示文摘 | Aike Qiao Youjun Liu | 2006 | Biomedical Materials and Engineering2006，16，3： | 1 |
| 6 | Structural Design and Numerical Analysis of a Novel Biodegradable Zinc Alloy Stent显示文摘Biodegradable zinc alloy stents are a prospective solution for complications caused by the incompatibility between artery and permanent stents.However,insufficient scaffolding has limited the clinical application of biodegradable zinc alloy stents.Therefore,in this study,a new stent concept was designed to improve the scaffolding.The mechanical performances of the new and a traditional design stent were investigated and compared using finite element analysis(FEA).The new and traditional design stent were expanded to the intended radial displacement of 0.24 mm under the expansion pressure of 0.58 MPa and 0.45 MPa,respectively.Then,a pressure load of 0.35 MPa was exerted on the outer surfaces of the two stents to compress them.The results showed that the radial recoiling ratio were 45.3%and 83.3%for the new and the traditional stent,respectively.The simulations demonstrate that the biodegradable zinc alloy stent offers enhanced support because of the new structural design.This study implies that biodegradable zinc alloy stent can be a new competitive intervention device for the future clinical cardiovascular application. | Kun Peng Aike Qiao Makoto Ohta Narendra Kurnia Putra Xinyang Cui Yongliang Mu Hitomi Anzai | 2018 | Computer Modeling in Engineering & Sciences2018，，10： | 1 |
| 7 | Haemodynamics Simulation for Carotid Artery Bifurcation显示文摘Finite element method is used to simulate the haemodynamics for carotid artery bifurcation. The model geometry was constructed using in vivo measured dimensions, and in vivo flow waveforms in internal and external carotids and pressure in common carotid artery are used to specify the boundary conditions for simulation. Attentions are paid to the local flow pattern, secondary flow and wall shear stress distribution at the midsinus of internal carotid artery. It is found that flow separation occurs near the outer wall of the internal carotid sinus during the downstroke of systole, and thus induces reversed flow with low velocity. The flow separation is transient and results in the oscillation of wall shear stress from -2 to 6 dyne/cm 2. Secondary flow in the cross section of midsinus presents during the whole cardiac cycle, and the maximum circumferential velocity value is about one-third of the mean axial velocity at the same moment. | LIU You-jun,QIAO Aike,ZHU Hai-weng,GAO Song | 2003 | Chinese Journal of Biomedical Engineering(English Edition)2003，12，3： | 0 |
| 8 | A New Approach through the Eye of a Needle and Its Potential Application in Bioscience显示文摘Putting the thread through the eye of a needle is a very ordinary issues in daily life.The mechanism of putting the thread through the eye of a needle is quite similar to threading a series of polymer chains through synthetic macrocycle in bioscience.A new rubbing approach to thread through the eye of a needle was proposed in this paper,and its potential application in the fields of biomechanics and mechanobiology to mimic the micro scale assembly processes was discussed. | Hongfang Song Aike Qiao | 2022 | Molecular & Cellular Biomechanics2022，19，3： | 0 |
| 9 | Research on Arterial Stiffness Status in Type 2 Diabetic Patients Based on Pulse Waveform Characteristics显示文摘For patients with type 2 diabetes,the evaluation of pulse waveform characteristics is helpful to understand changes in arterial stiffness.However,there is a lack of comprehensive analysis of pulse waveform parameters.Here,we aimed to investigate the changes in pulse waveform characteristics in patients with type 2 diabetes due to increased arterial stiffness.In this study,25 patients with type 2 diabetes and 50 healthy subjects were selected based on their clinical history.Age,height,weight,blood pressure,and pulse pressure were collected as the subjects’basic characteristics.The brachial-ankle pulse wave velocity(baPWV)was collected as an index of arterial stiffness.Parameters of time[the pulse wave period(T),the relative positions of peak point(T1)and notch point(T2),and pulse wave time difference between upper and lower limbs(T3)]and area[the total waveform area(A),and the areas of the waveform before(A1)and after(A2)the notch point]were extracted from the pulse wave signals as pulse waveform characteristics.An independent sample t-test was performed to determine whether there were significant differences between groups.Pearson’s correlation analysis was performed to determine the correlations between pulse waveform parameters and baPWV.There were significant differences in T3,A,A1,and A2 between the groups(p<0.05).For patients with type 2 diabetes,there were statistically significant correlations between baPWV and T3,A,A1,and A2(p<0.05).This study quantitatively assessed changes in arterial pulse waveform parameters in patients with type 2 diabetes.It was demonstrated that pulse waveform characteristics(T3,A,A1,and A2)could be used as indices of arterial stiffness in patients with type 2 diabetes. | Gaoyang Li Xiaorui Song Aike Qiao Makoto Ohta | 2018 | Computer Modeling in Engineering & Sciences2018，，11： | 0 |
| 10 | Effect of transcatheter aortic valve replacement on bicuspid coronary hemodynamics:A numerical study显示文摘To investigate the effects of transcatheter heart valve(THV)poses and bicuspid aortic valve(BAV)subtypes on coronary hemodynamics after transcatheter aortic valve replacement(TAVR).The computational models for BAV included left-right fusion(LR),non-coronary-left fusion(LN)and non-coronary-right fusion(RN).THV deployment height is defined as the distance below the aortic annulus of the lowest point of the stent,H_(1)=2mm,H_(2)=5mm and H_(3)=8mm,Orientations include O_(1)(one commissure is aligned with the raphe)and O_(2)(one commissure is aligned with the axis of non-fused leaflet symmetry).The maximum flow velocity(Vmax),mean wall shear stress(mWSS)and coronary perfusion pressure(CPP)of coronary were obtained by computational fluid dynamics(CFD)simulation.The CPP was 59%in left coronary and 82%in right coronary higher than that before deployment.At O_(1),the CPP of the LN left coronary and the RN right coronary was 74%and 79%higher than that before deployment.At O_(2),the CPP of the LN right coronary and the RN left coronary was 83%and 82%higher than that before deployment.When the THV deployment height is less than 2mm,Vmax and CPP of coronary arteries do not return to healthy TAV levels or changed weakly.The overlap of the THV commissure with the coronary ostium makes the coronary CPP so large that it exceeds the level of a healthy TAV. | Hongge Wei Zhuoran Qu Ziyao Geng Qianwen Hou Tianming Du Xinjin Luo Juntao Qiu Aike Qiao | 2023 | Medicine in Novel Technology and Devices2023，，2： | 0 |
| 11 | Model construction and numerical simulation of arterial remodeling after stent implantation with variations of cell concentration显示文摘Differences in concentration of molecules can cause different molecular diffusion.This issue has not been well studied in the vascular remodeling process with regards to is-stent restenosis.This study designed and built a model to explore the effect of differences in vascular cell concentration on vascular remodeling.Finite element analysis(FEA)models and the agent-based models(ABMs)were established to simulate the damage and proliferation process of vascular smooth muscle cells(VSMCs)caused by coronary artery stent implantation.The FEA model simulated the expansion of the stent in the coronary artery,the tensile stress was captured and imported into the ABM,and the damaged VSMCs proliferated to reduce their damage level.VSMCs were randomly distributed within a defined domain,and the number of VSMCs in a unit volume(or area)was defined as the concentration of VSMCs.VSMCs with the smallest concentration of VSMCs will preferentially proliferate,which simulates the cell proliferation affected by the concentration of VSMCs.The results showed that after stent implantation,VSMCs proliferated gradually from the severely damaged stent area to the lumen until the artery reached a steady state.By comparison,the loss of arterial lumen and the number of newly grown VSMCs were greater in the presence of the concentration than in its absence.Cells made full use of the lumen space under the influence of concentration differences,so the concentration was of great significance to vascular remodeling. | Yu Zhang Shiliang Chen Hanbing Zhang Chenyang Ma Tianming Du Aike Qiao | 2022 | Medicine in Novel Technology and Devices2022，，4： | 0 |
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