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| 1 | Safety,tolerability,and pharmacokinetics of VV116,an oral nucleoside analog against SARS-CoV-2,in Chinese healthy subjects显示文摘VV116(JT001)is an oral drug candidate of nucleoside analog against SARS-CoV-2.The purpose of the three phase I studies was to evaluate the safety,tolerability,and pharmacokinetics of single and multiple ascending oral doses of VV116 in healthy subjects,as well as the effect of food on the pharmacokinetics and safety of VV116.Three studies were launched sequentially:Study 1(single ascending-dose study,SAD),Study 2(multiple ascending-dose study,MAD),and Study 3(food-effect study,FE).A total of 86 healthy subjects were enrolled in the studies.VV116 tablets or placebo were administered per protocol requirements.Blood samples were collected at the scheduled time points for pharmacokinetic analysis.116-N1,the metabolite of VV116,was detected in plasma and calculated for the PK parameters.In SAD,AUC and Cmax increased in an approximately dose-proportional manner in the dose range of 25–800 mg.T_(1/2)was within 4.80–6.95 h.In MAD,the accumulation ratio for Cmax and AUC indicated a slight accumulation upon repeated dosing of VV116.In FE,the standard meal had no effect on Cmax and AUC of VV116.No serious adverse event occurred in the studies,and no subject withdrew from the studies due to adverse events.Thus,VV116 exhibited satisfactory safety and tolerability in healthy subjects,which supports the continued investigation of VV116 in patients with COVID-19. | Hong-jie Qian Yu Wang Meng-qi Zhang Yuan-chao Xie Qing-qing Wu Li-yu Liang Ye Cao Hua-qing Duan Guang-hui Tian Juan Ma Zhuo-bing Zhang Ning Li Jing-ying Jia Jing Zhang Haji Akber Aisa Jing-shan Shen Chen Yu Hua-liang Jiang Wen-hong Zhang Zhen Wang Gang-yi Liu | 2022 | Acta Pharmacologica Sinica2022，43，12： | 13 |
| 2 | Triterpenoids and phenolics from the fruiting bodies of Inonotus hispidus and their activations of melanogenesis and tyrosinase显示文摘Two new 24-methyl lanostane triterpenoids,hispindic acids A and B(1 and 2),and a new phenolic compound,hispinine(7),along with nine known compounds(3-6,and 8-12),were isolated from the fruiting bodies of Inonotus hispidus.Their structures were elucidated based on the extensive analysis of spectroscopic data(NMR and HRMS).Hispindic acid A(1) possesses an unusual formyl group at C-30.Compounds 1,3-4,and 8 showed stronger activate abilities of melanogenesis and tyrosinase in B16 melanoma cells than those of positive control,8-methoxypsoralen,at 50 | Qing Ren Xue-Ying Lu Jian-Xin Han Haji Akber Aisa Tao Yuan | 2017 | Chinese Chemical Letters2017，28，5： | 7 |
| 3 | Alkaloids of Nitraria sibirica Pall. decrease hypertension and albuminuria in angiotensin II-salt hypertension显示文摘In traditional Chinese medicine, Nitraria sibirica Pall.(Nitrariaceae) is used to treat hypertension. This study determined the effects of the total alkaloids of the leaves of Nitraria sibirica(NSTA) on blood pressure and albuminuria in mice treated with angiotensin II and a high-salt diet(ANG/HS). Adult mice were divided into three groups: control; infused with angiotensin II and fed a diet containing 4% NaCl(ANG/HS; and ANG/HS plus injection of NSTA(1 mg·kg-1·d-1, i.p.). After treatment of these regimens, daily water and food intake, kidney weight, blood pressure, urinary albumin excretion, renal concentrations of inflammatory markers, including soluble intercellular adhesion molecule-1(sICAM-1) and monocyte chemoattractant protein-1(MCP-1), and the expression of renal fibrosis markers were determined. Compared to the control group, the ANG/HS group had higher blood pressure and urinary albumin excretion. Treatment with NSTA in ANG/HS mice for three weeks significantly reduced blood pressure and urinary albumin excretion. ANG/HS treatment caused elevated levels of sICAM-1 and MCP-1, as well as increased fibrosis markers. Concurrent treatment with ANG/HS and NSTA attenuated the levels and expression of renal inflammatory and fibrosis markers. Treatment with NSTA effectively reduces hypertension-induced albuminuria through the reduction of renal inflammatory and fibrosis markers. | Mahinur Bakri YI Yang CHEN Ling-Dan Haji Akber Aisa WANG Mong-Heng | 2014 | Chinese Journal of Natural Medicines2014，12，4： | 5 |
| 4 | Assessment of the estrogenic activities of chickpea (Cicer arietinum L) sprout isoflavone extract in ovariectomized rats显示文摘 | Hai-rong MA Jie WANG Hong-xue QI Yan-hua GAO Li-juan PANG Yi YANG Zhen-hua WANG Ming-jun DUAN Hua CHEN Xu CAO Haji Akber AISA | 2013 | Acta Pharmacologica Sinica2013，34，3： | 5 |
| 5 | Fibrosing cholestatic hepatitis following cytotoxic chemotherapy for small-cell lung cancer显示文摘Fibrosing cholestatic hepatitis(FCH) is a variant of viral hepatitis reported in hepatitis B virus or hepatitis C virus infected liver,renal or bone transplantation recipients and in leukemia and lymphoma patients after conventional cytotoxic chemotherapy.FCH constitutes a well-described form of fulminant hepatitis having extensive fibrosis and severe cholestasis as its most characteristic pathological findings.Here,we report a case of a 49-year-old patient diagnosed with small-cell lung cancer who developed this condition following conventional chemotherapy-induced immunosuppression.This is the first reported case in the literature of FCH after conventional chemotherapy for a solid tumor.In addition to a detailed report of the case,a physiopathological examination of this potentially life-threatening condition and its treatment options are discussed. | Jaime Ceballos-Viro José M López-Picazo José L Pérez-Gracia Jesús J Sola Gregorio Aisa Ignacio Gil-Bazo | 2009 | World Journal of Gastroenterology2009，15，18： | 3 |
| 6 | piRNAs Can Trigger a Multigenerational Epigenetic Memory in the Germline of C. elegans显示文摘 | Alyson Ashe Alexandra Sapetschnig Eva-Maria Weick Jacinth Mitchell Marloes P. Bagijn Amy C. Cording Anna-Lisa Doebley Leonard D. Goldstein Nicolas J. Lehrbach Jérémie Le Pen Greta Pintacuda Aisa Sakaguchi Peter Sarkies Shawn Ahmed Eric A. Miska | 2012 | Cell2012，，1： | 2 |
| 7 | The mechanisms of melanogenesis inhibition by glabridin:molecular docking,PKA/MITF and MAPK/MITF pathways显示文摘Glabridin is the main ingredient of hydrophobic fraction in licorice extract and has been shown to have anti-melanogenesis activity in skins.However,the underlying mechanism(s)remain not completely understood.The aim of this study is thus to elucidate the possible mechanisms related to the melanogenesis suppression by glabridin in cultured B16 murine melanoma cells and in UVA radiation induced hyperpigmentation model of BALB/c mice as well.Molecular docking simulations revealed that between catalytic core residues and the compound.The treatment by glabridin significantly downregulated both transcriptional and/or protein expression of melanogenesis-related factors including melanocyte stimulating hormone receptor(MC1R),microphthalmia-associated transcription factor(MITF),tyrosinase(TYR),TYR-related protein-1(TRP-1)and TRP-2 in B16 cells.Both PKA/MITF and MAPK/MITF signaling pathways were found to be involved in the suppression of melanogenesis by glabridin in B16 cells.Also in vivo glabridin therapy significantly reduced hyperpigmentation,epidermal thickening,roughness and inflammation induced by frequent UVA exposure in mice skins,thus beneficial for skin healthcare.These data further look insights into the molecular mechanisms of melanogenesis suppression by glabridin,rationalizing the application of the natural compound for skin healthcare. | Chunxing Pan Xiaoying Liu Yating Zheng Zejun Zhang Yongliang Li Biao Che Guangrong Liu Lanyue Zhang Changzhi Dong Haji Akber Aisa Zhiyun Du Zhengqiang Yuan | 2023 | Food Science and Human Wellness2023，12，1： | 2 |
| 8 | Extracellular matrix degrading enzymes at the pmstasome surface 显示文摘 | BELLEZZA I AISA MC PALAZZO R | 2005 | Prostate Cancer and Prostatic Diseases2005，8，4： | 1 |
| 9 | Fucoidan induces apoptosis of human HS-sultan cells accompanies by activation of caspase-3 and down-regulation of ERK pathways显示文摘 | AISA Y MIYAKAWA Y NAKAZATO T | 2005 | Am J Hematol2005，78，1： | 1 |
| 10 | Fucoidan induces apoptosis of human HS-sultan cells accompanied by activation of caspase-3 and down-regulation of ERK pathways显示文摘 | Aisa Y Miyakawa Y Nakazato T | 2005 | Am J Hematol2005，78，1： | 1 |
| 11 | Effects of maternal separation on hypothalamic-pituitary-adrenal responses,cognition and vulnerability to stress in adult female rats显示文摘 | Aisa B Tordera R Lasheras B | | 0，，04： | 1 |
| 12 | Characterization of In-Mold Decoration Process and Influence of the Fabric Characteristics in This Process显示文摘 | A. Martinez J. Castany J. Aisa | 2011 | Materials and Manufacturing Processes2011，，9： | 1 |
| 13 | Cicatricial pemphigoid of the oropharynx after allogeneic stem cell transplantation for relapsed follicular lymphoma显示文摘 | Aisa Y Mori T Nakazato T | 2005 | Int J Hematol2005，82，3： | 1 |
| 14 | Jatrophane diterpenoids from Fructus Euphorbia sororia 显示文摘 | Huang Y Aisa HA | 2010 | Phytochem Lett2010，3，： | 1 |
| 15 | Endogenous longevity, health and economic growth:a slow growth for a longer life? 显示文摘 | AISA R PUEYO F | 2004 | Economics Bulletin2004，，9： | 1 |
| 16 | Copper heterogeneous nucleation on a palygorskite clay:an XRD,EXAFS and molecular modeling study显示文摘 | ALVAREZ-PUEBLA R A AISA C BLASCO J | 2004 | Appl Clay Sci2004，25，： | 1 |
| 17 | Bioas- say-guided isolation of antioxidants from Astragalus alta- icus by combination of chromatographic techniques 显示文摘 | Yang Chunyan Yang Yi Aisa Haji Akber | 2012 | Journal of Separation Science2012，35，8： | 1 |
| 18 | Basic fibroblast growth factor: effects on matrix remodeling, receptor expression, and transduction pathway in human periosteal fibroblasts with FGFR2 gene mutation显示文摘 | Bodo M Lilli C Aisa MC | 2002 | J Interferon Cytokine Res2002，22，6： | 1 |
| 19 | Primary central nerv- ous system post-transplant lymphoproliferative disorder pres- enting as cerebral hemorrhage after unrelated bone marrow transplantation 显示文摘 | AISA Y MORI T NAKAZATO T | 2009 | Transpl Infect Dis2009，11，5： | 1 |
| 20 | Components of Cichorium gan- dulsum Seeds显示文摘 | Wu H K Su Z Aisa H A | 2007 | Chcm Nat Compd2007，43，4： | 1 |
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