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| 1 | Safety and efficacy of Hansenula-derived PEGylated-interferon alpha-2a and ribavirin combination in chronic hepatitis C Egyptian children显示文摘AIM:To investigate the safety and efficacy of a Hansenula-derived PEGylated(polyethylene glycol)interferon(IFN)-alpha-2a(Reiferon Retard)plus ribavirin customized regimen in treatment-na?ve and previously treated(non-responders and relapsers)Egyptian children with chronic hepatitis C infection.METHODS:Forty-six children with chronic hepatitis C virus(HCV)infection were selected from three tertiary pediatric hepatology centers.Clinical and laboratory evaluations were undertaken.Quantitative polymerase chain reaction(PCR)for HCV-RNA was performed before starting treatment,and again at 4,12,24,48,72wk during treatment and 6 mo after treatment cessation.All patients were assigned to receive a weekly subcutaneous injection of PEG-IFN-alpha-2a plus daily oral ribavirin for 12 wk.Thirty-four patients were treatment-na?ve and 12 had a previous treatment trial.Patients were then divided according to PCR results into two groups.GroupⅠincluded patients who continued treatment on a weekly basis(7-d schedule),while groupⅡincluded patients who continued treatment on a 5-d schedule.Patients from either group who were PCR-negative at week 48,but had at least one PCRpositive test during therapy,were assigned to have an extended treatment course up to 72 wk.The occurrence of adverse effects was assessed during treatment and follow up.The study was registered at www.ClinicalTrials.gov(NCT02027493).RESULTS:Only 11 out of 46(23.9%)patients showed a sustained virological response(SVR),two patients were responders at the end of treatment;however,they were lost to follow up at 6 mo post treatment.Breakthrough was seen in 18(39.1%)patients,one patient(2.17%)showed relapse and 14(30.4%)were non-responders.Male gender,short duration of infection,low viral load,mild activity,and mild fibrosis were the factors related to a better response.On the other hand,patients with high viral load and absence of fibrosis failed to respond to treatment.Before treatment,liver transaminases were elevated.After commencing treatment,they were normalized in all patients at week 4 and were maintained normal in responders till the end of treatment,while they increased again significantly in non-responders(P=0.007 and 0.003 at week 24 and 72 respectively).The 5-d schedule did not affect the response rate(1/17 had SVR).Treatment duration(whether 48 wk or extended course to 72 wk)gave similar response rates(9/36 vs 2/8 respectively;P=0.49).Type of previous treatment(short acting IFN vs PEG-IFN)did not affect the response to retreatment.On the other hand,SVR was significantly higher in previous relapsers than in previous non-responders(P=0.039).Only mild reversible adverse effects were observed and children tolerated the treatment well.CONCLUSION:Reiferon Retard plus ribavirin combined therapy was safe.Our customized regimen did not influence SVR rates.Further trials on larger numbers of patients are warranted. | Suzan El Naghi Tawhida Y Abdel-Ghaffar Hanaa El-Karaksy Elham F Abdel-Aty Mona S El-Raziky Aleef A Allam Heba Helmy Hanaa A El-Araby Behairy E Behairy Mohamed A El-Guindi Hatem El-Sebaie Aisha Y Abdel-Ghaffar Nermin A Ehsan Ahmed M El-Hennawy Mostafa M Sira | 2014 | World Journal of Gastroenterology2014，20，16： | 2 |
| 2 | Leukemia inhhibitory factor:Role in human mesenchymal stem cells mediated immunosuptor:Role in human mesenchymal stem cells mediated immunosuppression显示文摘 | Aisha N Christelle M Sandrine B | 2008 | Cell Immuol2008，253，1： | 1 |
| 3 | Cytotoxic activity of Catharanthus roseus (Apocynaceae) crude extracts and pure compounds against human colorectal carcinoma cell line 显示文摘 | Siddiqui M J Ismail Z Aisha A F A | 2010 | lntern J Pharmacol2010，6，1： | 1 |
| 4 | Marine fouling in suez canal, Egypt 显示文摘 | Ahmed M E Aisha A B | 2004 | Egyptian journal of aquatic research2004，，： | 1 |
| 5 | Marine fouling in Suez Canal,Egypt显示文摘 | AHMED M EMARA AISHA A BELAL | 2004 | Aquatic Research2004，，： | 1 |
| 6 | In situsynthesis, photometric and spectroscop- ic studies of chelating system during the 1,4,7,10, 13, 16-hexaoxacyclooctadecane charge transfer reaction with different aeceptors显示文摘 | Aisha S M Hossan Hanaa M Abou-Melha Moamen S Refat | 2011 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy2011，79，： | 1 |
| 7 | Role of interleukin and tumor necrosis factorc in mat rix degradalion of human osteoarlhri- ic cartilage显示文摘 | Masahiko K Ginette RS Aisha M | 2005 | Art hritis & Rheum2005，52，1： | 1 |
| 8 | Geographic integration of hepatitis C virus: A global threat显示文摘AIM To assess hepatitis C virus(HCV) geographic integration, evaluate the spatial and temporal evolution of HCV worldwide and propose how to diminish its burden. METHODS A literature search of published articles was performed using Pub Med, MEDLINE and other related databases up to December 2015. A critical data assessment and analysis regarding the epidemiological integration of HCV was carried out using the meta-analysis method. RESULTS The data indicated that HCV has been integrated immensely over time and through various geographical regions worldwide. The history of HCV goes back to 1535 but between 1935 and 1965 it exhibited a rapid, exponential spread. This integration is clearly seen in the geo-epidemiology and phylogeography of HCV. HCV integration can be mirrored either as intra-continental or trans-continental. Migration, drug trafficking and HCV co-infection, together with other potential risk factors, have acted as a vehicle for this integration. Evidence shows that the geographic integration of HCV has been important in the global and regional distribution of HCV.CONCLUSION HCV geographic integration is clearly evident and this should be reflected in the prevention and treatment of this ongoing pandemic. | Mohamed A Daw Abdallah A El-Bouzedi Mohamed O Ahmed Aghnyia A Dau Mohamed M Agnan Aisha M Drah | 2016 | World Journal of Virology2016，5，4： | 1 |
| 9 | Impact melt distribution and emplacement on tycho:a new look at an old question显示文摘 | Aisha R M James W H Jean-Luc M Donald B C | | Lunar Planet Science0，，： | 1 |
| 10 | De-termination of free phenolic acids and antioxidant activity ofmethanolic extracts obtained from fruits and leaves of Che-nopodium album显示文摘 | Abdul HL Shahabuddin M Aisha N Khalid MK Arfa Y | 2011 | Food Chem2011，126，： | 1 |
| 11 | Chronic prostatitis: management strategies显示文摘 | Adam BM Amanda M Aisha T | 2009 | Drugs2009，69，1： | 1 |
| 12 | Marine fouling in Suez Canal, Egypt显示文摘 | Ahmed M E Aisha A B | 2004 | Aquatic Research2004，，： | 1 |
| 13 | Role of human papillomaviruses in esophageal squamous cell carcinoma显示文摘 | Surabhi S Liyanage Eva Segelov Suzanne M Garland Sepehr N Tabrizi Holly Seale Philip J Crowe Dominic E Dwyer Andrew Barbour Anthony T Newall Aisha Malik C Raina Macintyre | 2012 | Asia‐Pac J Clin Oncol2012，，1： | 1 |
| 14 | Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial显示文摘 | Christopher M Nutting James P Morden Kevin J Harrington Teresa Guerrero Urbano Shreerang A Bhide Catharine Clark Elizabeth A Miles Aisha B Miah Kate Newbold MaryAnne Tanay Fawzi Adab Sarah J Jefferies Christopher Scrase Beng K Yap Roger P A’Hern Mark A Sy | 2011 | Lancet Oncology2011，，2： | 1 |
| 15 | Expression of HER 2 in MCE-7 breast cancer cells modulates anti apoptotic proteins Survivin and Bcl-2 via the extracellular signal-related kinase (ERK) and phosphoinositide-3 kinase (PI3K) signalling pathways显示文摘 | Aisha S Linda M L Liu X L | 2008 | BMC Cancer2008，8，8： | 1 |
| 16 | Effect of malt pretreatment and/or cooking on phytate and essential amino acids contents and in vitro protein digestibility of corn flour显示文摘 | Aisha S M Fageer Elfadil E Babiker Abdullahi H El Tinay | 2004 | Food Chemistry2004，88，： | 1 |
| 17 | Effect of malt pretreatment and/or cooking on phytate and essential amino acids contents and in vitro protein digestibility of corn flour显示文摘 | Aisha S M Fageer Elfadil E Babiker Abdullahi H E1 Tinay | 2004 | Food Chemistry2004，88，： | 1 |
| 18 | Chronic prostatitismanagement strategies显示文摘 | Adam B M Amanda M Aisha T | 2009 | Drugs2009，69，1： | 1 |
| 19 | Effect of genotype,malt pretreatment and cooking on in vitro protein digestibility and protein fractions of corn显示文摘 | Aisha S M Fageer* A H El Tinay | 2004 | Food Chemistry2004，84，： | 1 |
| 20 | Role of interleukin-1 and tumor necrosis factorαin matrix degradation of human osteoarthritic cartilage显示文摘 | Masahiko K Ginette RS Aisha M | 2005 | Arthritis & Rheum2005，52，1： | 1 |
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