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	题名	作者	年代	出处	被引量
1	Frequent mutations of the CA simple sequence repeat in intron 1 of EGFR in mismatch repair-deficient colorectal cancers显示文摘AIM:To investigate the polymorphic simple sequencerepeat in intron 1 of the epidermal growth factor receptorgene(EGFR)(CA-SSRⅠ),which is known to affect theefficiency of gene transcription as a putative target of themismatch repair(MMR)machinery in colorectal tumors.METHODS:The CA-SSRⅠgenotype was analyzed ina total of 86 primary colorectal tumors,selected upontheir microsatellite instability(MSI)status[42 with highfrequency MSI(MSI-H)and 44 microsatellite stable(MSS)]and their respective normal tissue.The effect of the CA-SSRⅠgenotype on the expression of the EGFR gene wasevaluated in 18 specimens using quantitative real-timereverse transcription PCR and immunohistochemistry.RESULTS:Mutations in CA-SSRⅠwere detected in 86%(36 of 42)of MSI-H colorectal tumors and 0%(0 of 44)ofMSS tumors,indicating the EGFR gene as a novel putativespecific target of the defective MMR system(P<0.001).Impaired expression of EGFR was detected in most ofthe colorectal tumors analyzed[6/12(50%)at the mRNAlevel and 15/18(83%)at the peptide level].However,noassociation was apparent between EGFR expression andCA-SSRⅠstatus in tumors or normal tissues.CONCLUSION:Our results suggest that CA-SSRⅠsequence does not contribute to the regulation of EGFRtranscription in colon,and should thus not be consideredas a promising predictive marker for response to EGFRinhibitors in patients with colorectal cancer.	Marie-Pierre Buisine Agnès Wacrenier Christophe Mariette Emmanuelle Leteurtre Fabienne Escande Sana Aissi Amandine Ketele Annette Leclercq Nicole Porchet Thécla Lesuffleur	2008	World Journal of Gastroenterology2008，14，7：	3
2	Taxaneinduced peripheral neuropathy has good long-term prognosis:a 1-to 13-year evaluation显示文摘	Osmani K Vignes S Aissi M	2012	J Neurol2012，259，9：	1
3	E-business Process Modeling:The Next Big Step显示文摘	Aissi S Malu P Srinivasan K	2002	IEEE Computer2002，35，5：	1
4	E-Business Process Modeling:The Next Big Step显示文摘	Selim Aissi Pallavi Malu Krishnamurthy Srinivasan	2002	IEEE Computer2002，35，5：	1
5	E-business process modeling:the next big step显示文摘	AISSI S MALU P SRINIVASAN K	2002	IEEE Computer2002，35，5：	1
6	Lobstein's disease presenting with seizures 显示文摘	Boughammoura-Bouatay A Chebel S Aissi M	2007	Rev Neurol (Paris)2007，163，9：	1
7	Vasa previa:Of the diagnosis to neonatal prognosis显示文摘	Aissi G Sananes N Veujoz M	2013	J Gynecol Obstet Biol Reprod2013，42，6：	1
8	TP53 mutations in colorectal cancer from Tunisia: relationships with site of tumor origin, microsatellite instability and KRAS mutations 显示文摘	AISSI S BUISINE MP ZERIMECH F	2014	Mol Biol Rep2014，41，3：	1
9	Complexity of the min-max and min-max Regret Assignment Problems显示文摘	Aissi Hassene Bazgan Cristina Vanderpooten Daniel	2005	Operations Research Letters2005，33，：	1
10	Synthesis and biological evaluation of new quinoxaline derivatives of ICF01012 as melanoma-targeting probes显示文摘	Aissi R E Liu J R Besse S	2014	ACS Medicinal Chemistry Letters2014，5，5：	1
11	Min-max andmin-max regret versions of combinatorialoptimization problems:A survey显示文摘	Aissi H Bazgan C Vanderpooten D	2009	EuropeanJournal of Operational Research2009，197，2：	1
12	Alcohol intake after serotonin transporter inactivation in mice显示文摘	Kelai S Aissi F Lesch KP Cohen-Salmon C Hamon M Lanfumey L		0，，04：	1
13	Incidence, risk pro- file and morphological pattern of lower extremity venous throm- boembolism after urological cancer surgery显示文摘	CLE'MENT C ROSSI P AISSI K	2011	J Urol2011，186，6：	1
14	Molecular Evidence of Bartonella Infection in Demestic Dogs from Algeria, North Africa, by Polymerase Chain Reaction(PCR)显示文摘	Tahar Kernif Meriem Aissi Salah-Eddine		0，，02：	1
15	Test vector generation:current status and future trends显示文摘	Aissi Selim	2002	Software Quality Professional2002，4，2：	1
16	Observation of Hamiltonian chaos in wave-particle interaction显示文摘	Doveil F A Macor A Aissi	2008	Celestial Mechanics and Dynamical As- tronomy2008，102，13：	1
17	Synthesis of symmetrical and unsymmetrical functionalized arylphosphines from chlorophosphines and organozinc reagents显示文摘	LE Gall Erwan BEN Aissi Karima LACHAISE Isabelle	2006	Chem Inform2006，37，32：	1
18	E-Bussiness Process Modeling: The Next Big Step显示文摘	Aissi S Malu P Srinivasan K	2002	Computer2002，35，5：	1
19	Tuberoussclerosis and intracranial aneurysms: a rare association显示文摘	Aissi M Younes-Mhenni S Jerbi-0mme2zine S	2010	RevNeurol (Paris)2010，166，11：	1
20	In vitro binding of Bifidobacterium bifidum DSM 20082 to mucosal glycoproteins and hemagglutinating activity显示文摘	FONTAINE I F AISSI E A BOUQUELET S J	1994	Current Microbiology1994，28，：	1

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