| 2 | Plasma total homocysteine (THCY) level and other biochemical risk factors in hypertensives with and without cardiovascular events显示文摘Objective:The aim of this study is to assess the correlation between traditional cardiovascular risk factors and elevated plasma tHcy level in Nigerian hypertensive.Methods:Thirty-six hypertensive patients were recruited with 36 age and sex-matched controls.The age,sex and anthropometric measurements including height,weight and body mass index(BMI)were taken.Plasma total cholesterol,low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),triglycerides and tHcy were analyzed.The results of the two groups were compared.Results:The mean total cholesterol and LDL-C were significantly higher in the subjects than in the controls(P=0.01 and 0.03 respectively).On the other hand,means of HDL-C and triglycerides were not significantly different between the two groups(P=0.06 and 0.68 respectively).Mean total plasma tHcy was(12.95±4.9)μmol/L in hypertensive patients when compared with(11.29±3.6)μmol/L in the controls(P=0.09),however the mean tHcy was significantly higher in hypertensive patients who had stroke or myocardial infarction than those without these complications(one way Anova F=3.63,P=0.04).Significant positive correlation was seen between tHcy and systolic blood pressure,diastolic blood pressure,BMI and LDL-C.Conclusion:The study suggests that elevated plasma tHcy may predict occurrence of cardiovascular complications in hypertensive individuals. | Akande AA Salisu OT Omotoso ABO Kolo PM | 2009 | 海南医学院学报2009，15，11： | 0 |
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