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| 1 | Antiglycation,antioxidant and toxicological potential of polyphenol extracts of alligator pepper,ginger and nutmeg from Nigeria显示文摘Objective:To evaluate the antioxidant and antiglycation potential of polyphenols from three spices;alligator pepper,ginger and nutmeg.Methods:Polyphenol extracts of these spices were subjected to brine-shrimp lethality assay,phyloloxicily test,DPPH and superoxide anion radical scavenging as well as BSA-glucose antiglycation assay.Results:Results obtained showed that polyphenol extract of ginger has the highest anlioxidant potential with IC_(50)0.075 and 0.070 mg/mL.for DPPH and superoxide anion radical scavenging assay while alligator pepper displayed highest antiglycation activity with IC_(50)0.125 mg/mL.However,nutmeg extract exhibited weakest cytotoxic and phytotoxic potential with LD_(50)4359.70 and 1490μg/mL respectively.Conclusions:It can be concluded that the polyphenol extracts of alligator pepper,ginger and nutmeg displayed good antioxidant as well as antiglycation potential and are,safe for consumption. | Kazeem MI Akanji MA Hafizur Rahman M Choudhary MI | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，9： | 7 |
| 2 | Abortifacient Potential of Aqueous Extract of Senna alata Leaves in Rats显示文摘Objective To study the abortifacient activity of aqueous extract of Senna alata leaves in female Wistar rats.Methods Pregnant rats weighing 143.65 ± 13.11 g were completely randomized into 5 groups(A-E).Rats in group A(negative control) were orally administered,once daily with 0.5 ml of distilled water on days 10-18 post-coitum while those in groups B,C,D,and E were treated exactly like the negative control except they received the same volume containing 2.85 mg/kg body weight of mifepristone(group B,reference drug),250,500 and 1 000 mg/kg body weight of the extract respectively(groups C-E).Results Phytochemical screening of the extract showed positive results for saponins(1.22%),flavonoids(1.06%),cardiac glycosides(0.20%),cardenolides and dienolides(0.18%),phenolics(0.44%) and alkaloids(0.52%).Respiratory distress,salivation,diarrhoea,changes in the appearance of hair as well as maternal mortality were not observed at any time during the exposure period except in the mifepristone-treated animals where there was episode of diarrhoea and tiredness.The extract significantly reduced(P<0.05) the number of life foetus,weight and survival ratio of the foetus,numbers of implantations and Corpora lutea,implantation index,progesterone,prolactin,estradiol,follicle stimulating and luteinizing hormones whereas the number of dead foetus,number and percentage of rats that aborted,percentage vaginal opening,resorption index,pre-and post-implantation losses increased significantly.In addition,mifepristone-treated animals produced resorption index that compared well with the distilled water control.There was also no dead or life foetus and serum progesterone concentration was increased in the animals treated with mifepristone.All cases of abortion were accompanied with vaginal bleeding.Although,the final weight of the rats increased significantly,the feed and water intake were not significantly altered in all the treatment groups.The weight of the uterus,uterine-body weight ratio,length of the right uterus horn and uterine cholesterol decreased significantly in all the treatment groups.The uterine alkaline phosphatase activity and glucose concentration increased in only the extract-treated animals whereas mifepristone decreased the uterine alkaline phosphatase activity and glucose content of the animals.Conclusion This study has provided evidence to the age-long claim of S.alata leaves in 'washing the uterus'.The abortifacient properties were most pronounced at 500 and 1 000 mg/kg body weight of the extract and were similar to the animals treated with 2.85 mg/kg body weight of mifepristone.Hormonal influence,changes in implantation site,estrogenicity and uterogenicity are suggested as possible mechanism of abortifacient activity of aqueous extract of S.alata leaves.Overall,the extract may be used as an abortifacient especially at 500 and 1 000 mg/kg body weight and therefore not safe for consumption as oral remedy during pregnancy. | Yakubu MT Adeshina AO Oladiji AT Akanji MA Oloyede OB Jimoh GA Olatinwo AWO Afolayan AJ | 2010 | Journal of Reproduction and Contraception2010，21，3： | 2 |
| 3 | Hypothyroidism re- sults in small dense LDL independent of IRS traits and hypertrig- lyceridemia显示文摘 | Abbas JM Chakraborty J Akanji AO | 2008 | Endocr J2008，55，2： | 1 |
| 4 | Serum lipo-protein(a) concentration as a cardiovascular risk factor in Ku-waiti type 2 diabetic patients 显示文摘 | Abdella NA Mojiminiyi OA Akanji AO | 2001 | J Diabetes Complications2001，15，5： | 1 |
| 5 | Lipoprotein(a), tissue plasminogen activator and plasrninogen activator inhibitor-1 levels in hyperlipidemic patients in kuwait显示文摘 | Akanji AO Abdullah A Tahzeeb S | 1997 | Eur J Clin Invest1997，27，5： | 1 |
| 6 | Associations of plasma homocysteine concentration in subjects with type 2 diabetes mellitus显示文摘 | Abdella NA Mojiminiyi OA Akanji AO | 2002 | Acta Diabetol2002，39，： | 1 |
| 7 | Homocysteine and endogenous markers of renal function in type 2 diabetic patients without coronary heart disease显示文摘 | ABDELLA N MOJIMINIYI O A AKANJI A O | 2000 | Diabetes Res Clin Pract2000，50，： | 1 |
| 8 | Dynamic compression influences inlerleukin-1 beta-induced nitric oxide and proslaglandin E2 release by articular chondrocytes viaalterations in iNOS and COX-2 expression显示文摘 | Chowdliury TT Akanji OO Sailer DM | 2008 | Morheology2008，45，34： | 1 |
| 9 | Dynamic compression alters NFkappaB activation and IkappnB-alpha expression in IL- 1beta-stimulated clioiidrocyte/agarose conslructs显示文摘 | Akanji OO Sakthithasan V Salter DM | 2010 | Inflamm Res2010，59，1： | 1 |
| 10 | The insulin-like growth factor system,metabolic syndrome,and cardiovascular disease risk显示文摘 | Akanji A O Smith R J | 2012 | Metab Syndr Relat Disord2012，10，1： | 1 |
| 11 | Related articles,metabolic and anthropometric determinants of serum Lp (a) concentrations and Apo(a) polymorphism in a healthy Arab population 显示文摘 | Akanji AO al-Shayji IA Kumar P | 1999 | Int J Obes Relat Metab Disord1999，23，8： | 1 |
| 12 | Determinants of glycated LDL levels in nondiabetic and diabetic hyperlipidaemic patients in Kuwait 显示文摘 | Akanji AO Abdella N Mojiminiyi OA | 2002 | Clin Chim Acta2002，317，12： | 1 |
| 13 | Toxicological implications of aqueous extract of Bambusa vulgaris leaves in pregnant Dutch rabbits显示文摘 | Yakubu MT Bukoye BB Oladiji AT Akanji MA | 2009 | Human and Experimental Toxicology2009，，9： | 1 |
| 14 | The role of intrauterine insemination in male infertility显示文摘 | Akanji Tijani H Bhattacharya S | 2010 | Hum Fertil(Camb)2010，13，： | 1 |
| 15 | Androgenic potentials of aqueous extract of Massularia acuminata (G. Don) Bullock ex Hoyl. stem in male Wistar rats显示文摘 | Musa Toyin Yakubu Musbau Adewumi Akanji Adenike Temidayo Oladiji Ayoade Abdulfatai Adesokan | 2008 | Journal of Ethnopharmacology2008，，3： | 1 |
| 16 | Relationship of serum total sialic acid concentrations with diabetic complications and cardiovascular risk factors in Kuwaiti Type 2 diabetics显示文摘 | Abdella N Akanji A Mojiminiyi O | 2000 | Diabetes Research and Clinical Practice2000，50，： | 1 |
| 17 | Relationship of serum total sialic acid concentrations with diabetic complications and cardiovascular risk factors in Kuwaiti Type 2 diabetics显示文摘 | Abdella N Akanji AO Mojiminiyi O | 2000 | Diabetes Res Clin Pract2000，50，1： | 1 |
| 18 | Associa- tions of apolipopmtein E polymorphism with low-density lipoprotein size and subfraction profiles in Arab patients with coronary heart disease 显示文摘 | AKANJI AO SURESH CG FATANIA HR | 2007 | Metabolism2007，56，4： | 1 |
| 19 | Dynamic compression in- fluences interleukin-1 beta-induced nitric oxide and prostaglandin E2 re- lease by articular chondrocytes via alterations in iNOS and COX-2 ex- pression 显示文摘 | Chowdhury TT Akanji OO Salter DM | 2008 | Biorheology2008，45，34： | 1 |
| 20 | Associations of apolipoprotein E polymorphism with low-density lipoprotein size and subfraction profiles in Arab patients with coronary heart disease显示文摘 | Abayomi O. Akanji Cheriyil G. Suresh Hasmukh R. Fatania Reem Al-Radwan Muhammad Zubaid | 2007 | Metabolism2007，，4： | 1 |
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