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| 1 | Endoscopic retrograde cholangiopancreatography during pregnancy without radiation显示文摘AIM: To present our experience with pregnant patients who underwent endoscopic retrograde cholangiopancreatography (ERCP) without using radiation, and to evaluate the acceptability of this alternative therapeutic pathway for ERCP during pregnancy. METHODS: Between 2000 and 2008, six pregnant women underwent seven ERCP procedures. ERCP was performed under mild sedoanalgesia induced with pethidine HCl and midazolam. The bile duct was cannulated with a guidewire through the papilla. A catheter was slid over the guidewire and bile aspiration and/or visualization of the bile oozing around the guidewire was used to confirm correct cannulation. Following sphincterotomy, the bile duct was cleared by balloon sweeping. When indicated, stents were placed. Confirmation of successful biliary cannulation and stone extraction was made by laboratory, radiological and clinical improvement. Neither fluoroscopy nor spot radiography was used during the procedure. RESULTS: The mean age of the patients was 28 years (range, 21-33 years). The mean gestational age for the fetus was 23 wk (range, 14-34 wk). Five patients underwent ERCP because of choledocholithiasis and/orcholedocholithiasis-induced acute cholangitis. In one case, a stone was extracted after precut papillotomy with a needle-knife, since the stone was impacted. One patient had ERCP because of persistent biliary fistula after hepatic hydatid disease surgery. Following sphincterotomy, scoleces were removed from the common bile duct. Two weeks later, because of the absence of fistula closure, repeat ERCP was performed and a stent was placed. The fistula was closed after stent placement. Neither post-ERCP complications nor premature birth or abortion was seen. CONCLUSION: Non-radiation ERCP in experienced hands can be performed during pregnancy. Stent placement should be considered in cases for which complete common bile duct clearance is dubious because of a lack of visualization of the biliary tree. | Adem Akcakaya Orhan Veli Ozkan Ismail Okan Orhan Kocaman Mustafa Sahin | 2009 | World Journal of Gastroenterology2009，15，29： | 17 |
| 2 | Mechanical lithotripsy and/or stenting in management of difficult common bile duct stones显示文摘BACKGROUND:Mechanical lithotripsy and/or stent insertion is the alternative therapeutic approach in difficult endoscopic retrograde cholangiopancreatography (ERCP)case.This study was designed to investigate the appropriate treatment for extraction of bile duct stones in difficult cases of ERCP. METHODS:Between 2000 and 2008,744 ERCP procedures were performed in 592 patients with choledocholithiasis in our endoscopy unit.The demographic features,and clinical and laboratory findings were collected from a prospectively held database.Bile duct calculi were extracted by basket and/or balloon catheter following ERCP and sphincterotomy.Patients with retained stones were regarded as difficult cases.These patients were treated with mechanical lithotripsy and those with incomplete clearance of stones underwent stent placement. RESULTS:Two hundred and forty-five patients(41%) were male and 347(59%)were female with a mean age of 58 years(range 19-95 years).Stones were impacted in 27 patients(5%).Stone extraction was performed by basket and/or balloon catheter in 610 ERCP procedures,and lithotripsy was performed in 70 ERCP procedures.Forty- four patients underwent stent insertion,and 20 underwent stent replacement.Morbidity occurred in 39 patients (5%),with no mortality associated with the procedure.Hemorrhage occurred in 9 patients and basket impaction in 4.Mild pancreatitis and cholangitis developed in 12 and 11 patients,respectively. CONCLUSION:Difficult cases of bile duct stones can be treated successfully with lithotripsy,and a stent should be applied when the common bile duct cannot be cleared completely. | Adem Akcakaya Orhan Veli Ozkan Gurhan Bas Atilla Karakelleoglu Orhan Kocaman Ismail Okan Mustafa Sahin | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，5： | 5 |
| 3 | 雷珠单抗治疗新生血管性年龄相关性黄斑变性的长期疗效(英文)显示文摘目的:研究就诊于我院新生血管性年龄相关性黄斑变性(NV-AMD)患者使用雷珠单抗治疗后3年的疗效。方法:回顾性研究。共纳入73例(101眼)患者。根据入组时视力情况(ETDRS chart),患者被分为3组。第1组:视力≤35;第2组:视力36~54;第3组:视力≥55字母。患者接受3次,每次0.5 mg的雷珠单抗负荷剂量,之后根据病情决定是否再次注射。对患者每月进行一次随访,进行视力、详细的眼前节及眼底的生物显微镜,以及光学相干断层扫描(OCT)检查。对最接近12、24、36mo的视力检查结果进行分析。结果:纳入的101眼中,男性57眼,女性44眼。患者平均年龄75.1岁。治疗24mo和36mo时,三组患者之间视力变化情况差异均有统计学意义(P=0.002,0.0001)。治疗36mo后,第2组视力较入组时显著改善(P=0.001),第3组患者视力改善不显著。随访12、24、36mo时,第1组视力无明显变化的患者人数最多。所有患者平均注射雷珠单抗7.3次,随访次数23.9次。结论:入组时视力情况尚可的患者视力改善最明显。视力较差和视力较好的患者视力改变不明显。最终视力与注射次数无明显关系。 | Burak Simsek Aylin Ardagil Akcakaya Isilay Ozsoy Koyun Sevil Ari Yaylali | 2018 | 国际眼科杂志2018，18，3： | 3 |
| 4 | Posterior fossa epidural hema- tomas in children: clinical experience with 40 cases显示文摘 | Seneer A Aras Y Akcakaya MO | 2012 | Neurosurg Pediatr2012，9，2： | 1 |
| 5 | Manifold learning by preserving distance orders显示文摘 | Ataer-Cansizoglu E Akcakaya M Orhan U | 2014 | Pattern Recognition Letters2014，38，： | 1 |
| 6 | Ratio-dependent prediction:an abstraction that works显示文摘 | Akcakaya H Rj Arditi R Ginzburg L R | 1995 | Ecology1995，76，： | 1 |
| 7 | Variation in plankton densities among lakes:A case for ratiodependent models显示文摘 | Arditi R Gimzburg L R Akcakaya H R | 1991 | American Naturalists1991，138，5： | 1 |
| 8 | Population cycles of mannuls:evidence for a ratio-dependent predation pyhothesis显示文摘 | AKCAKAYA H R | 1992 | Ecol Monogr1992，62，： | 1 |
| 9 | Global gap analysis:priority regions for expanding the global protected-area network显示文摘 | Rodrigues A S L H R Akcakaya S J Andelman | 2004 | Bio Science2004，54，12： | 1 |
| 10 | Fully Endoscopic Interlaminar and Transforaminal Lumbar Discectomy: Short-term Clinical Results of 163 Surgically Treated Patients 显示文摘 | Sencer A Yorukoglu AG Akcakaya MO | 2014 | World Neurosurg2014，5，32： | 1 |
| 11 | MIMO Radar Sensi- tivity Analysis for Target Detection显示文摘 | AKCAKAYA M NEHORAI A | 2011 | IEEE Trans on Signal Processing2011，59，7： | 1 |
| 12 | Comparison of Mechanical Bowel Obstruction Cases of Intra-abdominal Tumor and Non-tumoral Origin显示文摘 | Adem Akcakaya MD Mustafa Sahin MD Aytekin Coskun MD Sinan Demiray MD | 2006 | World Journal of Surgery2006，，7： | 1 |
| 13 | Variation in plankton densities among lakes: a case for ratio-dependent models显示文摘 | Arditi R Ginzburg L R Akcakaya H R | 1991 | American Naturalist1991，138，： | 1 |
| 14 | Combined saturation/inversion recovery sequences for improved evaluation of scar and diffuse fibrosis in patients with arrhythmia or heart rate variability显示文摘 | Weingartner S Akcakaya M Basha T | 2014 | Magn Reson Med2014，71，3： | 1 |
| 15 | Skin test hypersensitivity for childhood asthma in Istanbul during a period of 16years显示文摘 | Akcakaya N Cokugras H Carncioglu Y Ozdemir M | | 0，，： | 1 |
| 16 | Integrating landscape and metapopulation modeling approaches: Viability of the sharp-tailed grouse in a dynamic landscape 显示文摘 | AkCAkaya H R Radeloff V C Mladenoff D J | 2004 | Conservation Biology2004，18，2： | 1 |
| 17 | MIMO radar detection and adaptive design under a phase synchro -nization mismatch 显示文摘 | Akcakaya M Nehorai A | 2010 | IEEE Trans On Signal Processing2010，58，10： | 1 |
| 18 | Performance of Sparse Representation Algorithms Using Randomly Generated Frames 显示文摘 | Akcakaya M Tarokh V | 2007 | IEEE Trans on Signal Processing Letters2007，14，11： | 1 |
| 19 | Posterior fossa epiduralhematomas in children: clinical experience with 40 cases显示文摘 | Sencer A Aras Y Akcakaya MO | 2012 | JNeurosurg Pediatr2012，9，2： | 1 |
| 20 | Serum microRNA expression in pregnancies with preeclampsia 显示文摘 | Gunel T Zeybek YG Akcakaya P | 2011 | Genet Mol Res2011，10，4： | 1 |
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