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| 1 | Phenolic compounds affect production of pyocyanin, swarming motility and biofilm formation of Pseudomonas aeruginosa显示文摘Objective: To investigate the effects of plant-derived phenolic compounds(i.e. caffeic acid, cinnamic acid, ferulic acid and vanillic acid) on the production of quorum sensing regulated virulence factors such as pyocyanin, biofilm formation and swarming motility of Pseudomonas aeruginosa(P. aeruginosa) isolates.Methods: Fourteen clinical P. aeruginosa isolates obtained from urine samples and P. aeruginosa PA01 strain were included in the study. The antibacterial effects of phenolic compounds were screened by well diffusion assay. Pyocyanin and biofilm activity were measured from culture supernatants and the absorbance values were measured using a spectrophotometer. Swarming plates supplemented with phenolic acids were point inoculated with P. aeruginosa strains and the ability to swarm was determined by measuring the distance of swarming from the central inoculation site.Results: Tested phenolic compounds reduced the production of pyocyanin and biofilm formation without affecting growth compared to untreated cultures. Moreover, these compounds blocked about 50% of biofilm production and swarming motility in P. aeruginosa isolates.Conclusions: We may suggest that if swarming and consecutive biofilm formation could be inhibited by the natural products as shown in our study, the bacteria could not attach to the surfaces and produce chronic infections. Antimicrobials and natural products could be combined and the dosage of antimicrobials could be reduced to overcome antimicrobial resistance and drug side effects. | Aylin Ugurlu Aysegul Karahasan Yagci Seyhan Ulusoy Burak Aksu Gulgun Bosgelmez-Tinaz | 2016 | Asian Pacific Journal of Tropical Biomedicine2016，6，8： | 3 |
| 2 | Differential diagnosis in ulcerative colitis in an adolescent: Chronic granulomatous disease needs extra attention显示文摘Chronic granulomatous disease(CGD) is a primary immune deficiency that is commonly diagnosed under the age of 5 years(95%) and is rarely seen in adulthood. CGD may manifest as inflammatory bowel disease(IBD) in childhood. Without proper diagnosis, these patients may be monitored for years as IBD; some may even be regarded as steroid-resistant ulcerative colitis(UC) and end up having a colectomy. In this case report, we described a patient who had been followedup for years as UC and subsequently underwent colectomy, but was finally diagnosed in adulthood as primary immune deficiency. | Daniel Kotlarz Odul Egritas Gurkan Zehra Sule Haskologlu Ozgur Ekinci Aysel Aksu Unlusoy Neslihan Gürcan Kaya Jacek Puchalka Cristoph Klein Buket Dalgic | 2017 | World Journal of Gastrointestinal Pathophysiology2017，8，2： | 2 |
| 3 | Traumatic dislocation and fracture dislocation of the hip:a long-term follow-up study 显示文摘 | Sahin V Karakas ES Aksu S | 2003 | Trauma2003，54，3： | 1 |
| 4 | Competitive biosorption ofphenol and chromium(VI)from binary mixtures onto dried aaaerobic activated sludge显示文摘 | Aksu Z Akpinar D | 2001 | Biochemical Engineering Journal2001，，7： | 1 |
| 5 | Biosorption of reactive dyes by dried activated sludge-kinetic modeling显示文摘 | Aksu Z | 2001 | Biochemical Engineering Journal2001，7，1： | 1 |
| 6 | Effect of dietary probiotic on the pH and colour characteristics of carcasses, breast fillets and drumsticks of broilers显示文摘 | Karaoglu M Aksu M I Esenbuga N | 2004 | Animal Science2004，78，253： | 1 |
| 7 | Complications encountered in proximal humerus fractures treated with locking plate fixation显示文摘 | Aksu N G(o)(g)ü(s) A Kara AN | | 0，，02： | 1 |
| 8 | Retinopathy is related to the angiographically detected severity and extent of coronary artery disease in patients with type 2 diabetes mellitus显示文摘 | Norgaz T Hobikoglu G Aksu H | | 0，，： | 1 |
| 9 | Production of carotenoids by the isolated yeast of Rhodotorula glutinis显示文摘 | AKSU Z EREN A T | 2007 | Biochemical Engineering Journal2007，35，2： | 1 |
| 10 | Takayasu' s arteritis in Turkey-clinical and angiographic features of 248 patients 显示文摘 | Bieakeigil M Aksu K Kamali S | 2009 | Clin Exp Rheumatol2009，27，152： | 1 |
| 11 | Application of biosorption for the removal of organic pollutants:a review显示文摘 | AKSU Z | 2005 | Process biochem2005，40，： | 1 |
| 12 | Comparison of 3 doses of ropivacaine for epidural anesthesia in transurethral surgery 显示文摘 | Guler G Aksu R Dogru K | 2009 | Saudi Med J2009，30，1： | 1 |
| 13 | No mutation in the SLC2A2 (GLUT2) gene in a Turkish infant with Fanconi - Bickel syndrome 显示文摘 | Ozer E A N Aksu E Uclar | 2003 | Pediatr Nephrol2003，18，4： | 1 |
| 14 | Simultaneous adsorption of phenol and chromium(VI) from binary mixtures onto powdered activated carbon 显示文摘 | Aksu Z Akpinar D | 2000 | Environ Sci Heal A2000，35，3： | 1 |
| 15 | Heavy metal concentrations in water,suspended matter and sediment from Gkova Bay,Turkey显示文摘 | BALKIS N AKSU A | 2009 | Environ Monit Assess2009，41，23： | 1 |
| 16 | Effect of a dietary probiotie on some quality characteristics of raw broiler drum- sticks and breast meat显示文摘 | Aksu M I Karaoglu M Esenbuga N | 2005 | Journal of Muscle Foods2005，，16： | 1 |
| 17 | Complications encountered in proximal humerus fractures treated with locking plate fixation显示文摘 | Aksu N Giigu- A Kara AN | 2010 | Acta Orthop Traumatol Turc2010，44，： | 1 |
| 18 | The efficiency of puhed radio- frequency application on L5 ahd 16 dorsal roots in rabbits de- veloping neiropathc pan显示文摘 | Aksu R Ugur F Bicer C | 2010 | Reg Aaesth Pain Med2010，35，4： | 1 |
| 19 | Hyper-immunoglobulin M syndrome type 3 with normal CD40 cell surface expression显示文摘 | Karaca NE Forveille M Aksu G | | 0，，01： | 1 |
| 20 | Reversible corpuscallosum splenial lesion due to steroid therapy 显示文摘 | Aksu B Kurtcan S Alkan A | 2014 | J Neuro-imaging2014，14，： | 1 |
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