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| 1 | Validation of the Rockall scoring system for outcomes from non-variceal upper gastrointestinal bleeding in a Canadian setting显示文摘AIM: To validate the Rockall scoring system for predicting outcomes of rebleeding, and the need for a surgical procedure and death. METHODS: We used data extracted from the Registry of Upper Gastrointestinal Bleeding and Endoscopy including information of 1869 patients with non-variceal upper gastrointestinal bleeding treated in Canadian hospitals. Risk scores were calculated and used to classify patients based on outcomes. For each outcome, we used χ2 goodness-of-fit tests to assess the degree of calibration, and built receiver operating characteristic curves and calculated the area under the curve (AUC) to evaluate the discriminative ability of the scoring system. RESULTS: For rebleeding, the χ2 goodness-of-fit test indicated an acceptable fit for the model [χ2 (8) = 12.83, P = 0.12]. For surgical procedures [χ2 (8) = 5.3, P = 0.73] and death [χ2 (8) = 3.78, P = 0.88], the tests showed solid correspondence between observed proportions and predicted probabilities. The AUC was 0.59 (95% CI: 0.55-0.62) for the outcome of rebleeding and 0.60 (95% CI: 0.54-0.67) for surgical procedures, representing apoor discriminative ability of the scoring system. For the outcome of death, the AUC was 0.73 (95% CI: 0.69-0.78), indicating an acceptable discriminative ability. CONCLUSION: The Rockall scoring system provides an acceptable tool to predict death, but performs poorly for endpoints of rebleeding and surgical procedures. | Robert A Enns Yves M Gagnon Alan N Barkun David Armstrong Jamie C Gregor Richard N Fedorak RUGBE Investigators Group | 2006 | World Journal of Gastroenterology2006，12，48： | 14 |
| 2 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 3 | The vehicle routing problem with stochastic demand and duration constraints显示文摘 | ALAN L E JUAN C M MARTIN S | | 0，，4： | 1 |
| 4 | Comparison of ethanol and sodi- um tetradecyl sulfate in the sclerotherapy of renal cyst 显示文摘 | Demir E Alan C Kilciler M | 2007 | J En- dourol2007，21，8： | 1 |
| 5 | Electromagnetic induction by a finite electric dipole source over a 2-D earth显示文摘 | Unsworth J M Bryan J T Alan D C | 1993 | Geophysics1993，58，2： | 1 |
| 6 | Application of the analytical hierarchy process to establish health care waste management systems that minimise infection risks in developing countries 显示文摘 | Alan C Brent David E C Rogers Tsaletseng S M Ramabitsa-Siimane Mark B Rohwer | 2007 | European Journal of Operational Research 1812007，，： | 1 |
| 7 | Model- ling the transition towards a green economy in South Africa 显示文摘 | Josephine K Musango Alan C Brent Andrea M Bassi | 2014 | Technological Forecasting & Social Change2014，，87： | 1 |
| 8 | A novel and effective particle swarm optimization like algorithm with extrapolation technique 显示文摘 | Senthil Arumugam M Rao M V C Tan Alan W C | 2009 | Applied Soft Computing2009，9，1： | 1 |
| 9 | Evaluation of phenolic compounds in commercial fruit juices and fruit drinks显示文摘 | WILLIAM M SERENA C M ALAN C | 2007 | J Agric Food Chem2007，55，8： | 1 |
| 10 | Effect of Sur- face Finish on Gear Tooth Friction 显示文摘 | Britton R D Elcoate C D Alanou M P | 2000 | Journal of tribology2000，122，1： | 1 |
| 11 | Complementarities and Spillovers in Mergers: an Empirical Investigation Using Patent Data显示文摘 | Alan C M Gordon C R | 2011 | Eco- nomics of Innovation and New Technology2011，20，3： | 1 |
| 12 | Eotaxin is specifically cleaved by hookworm metalloproteases preventing its action in vitro and in vivo 显示文摘 | Fiona J C Alan Brown Dolores M C | 2000 | J Immunology2000，165，11： | 1 |
| 13 | A sparse signal reconstruction perspective for source localization with sensor arrays 显示文摘 | Dmitry M Mujdat C Alan S W | 2005 | IEEE Transactions on Signal Processing2005，53，8： | 1 |
| 14 | The synthesis,structural char-acterization and in vitro anti-cancer activity of novel N-(3-ferrocenyl-2-naphthoyl) dipeptide ethyl esters and novel N-(6-ferrocenyl-2-naphthoyl) dipeptide ethyl esters显示文摘 | Aine M Alan C Dermot O | 2009 | J Organomet Chem2009，694，6： | 1 |
| 15 | Self-oriented regular arrays of carbon nanotubes and their field emission properties显示文摘 | FAN S S CHAPLINE M G FRANKIN N R TOMBLER T W ALAN C M DAI H J | 1999 | Science1999，283，： | 1 |
| 16 | Comparative approaches for assessing network vulnerability显示文摘 | Tony H G Timothy C M Alan T M | 2008 | International Regional Science Review2008，31，1： | 1 |
| 17 | Posterolateral transfo raminal selective endoscopic discectomy and thermal annuloplasty for chronic lumbar discogenic pain=a minimal access visualized in tradiscal surgical procedure显示文摘 | TSOU P M ALAN Y C YEUNG A T | 2004 | Spine J2004，4，5： | 1 |
| 18 | Antioxidant and metal chelating activities of peptide fractions from phaseolin and bean protein hydrolysates显示文摘 | JANET C ALAN JAVIER H CRISTIAN J M | | 0，，03： | 1 |
| 19 | Idiopathic pulmonary fibrosis: physiologic tests, quantitative CT indexes, and CT visual scores as predictors of mortality 显示文摘 | Best Alan C Meng Jiangfeng Lynch Anne M | 2008 | J Radiology2008，246，3： | 1 |
| 20 | Self-assembly of mesoscopicatly ordered chromatic polydiacetylene/silica nanocomposites显示文摘 | Lu Y F Yi Y Alan A Lu M C | 2001 | Nature2001，410，： | 1 |
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