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| 1 | 抗炎介质表达缺陷参与中性粒细胞型支气管哮喘发病机制:半乳糖凝集素-3和白细胞介素-1RA/白细胞介素-1beta比例显著下降显示文摘支气管哮喘(哮喘)是具有异质性的气道炎症性疾病,其主要特点表现为气道高反应和可变的气流受限。在哮喘的发病机制中,过敏原诱导的TH2淋巴细胞激活以及IL-5介导的嗜酸粒细胞渗出起到重要的作用。近年来发现超过50%的哮喘患者气道的嗜酸粒细胞水平并不增高,并将这种亚型定义为非嗜酸粒细胞型哮喘。其中部分患者表现为气道中性粒细胞明显增高,称为中性粒细胞型哮喘。 | 高鹏 Peter G Gibson Katherine J Baines Ian A Yang John W Upham Paul N Reynolds Sandra Hodge Alan L James Christine Jenkins Matthew J Peters 张捷 Jodie L Simpson | 2016 | 中华结核和呼吸杂志2016，39，11： | 5 |
| 2 | 新加坡成人慢性呼吸系统疾病患者6分钟步行距离的最小临床重要差异值研究(英文)显示文摘目的:6 min步行距离(6MWD)是临床上常见的功能性运动能力测试,特别是对于慢性呼吸系统疾病患者。一些文献记载了关于白种人的6MWD的最小临床重要差异(MCID),但对亚洲人群的相关信息未见记载。本研究旨在建立亚洲成人慢性呼吸道疾病患者6MWD的最小临床重要差异。方法:采用'锚定'法和'分布'法对新加坡中央医院肺康复计划登记处的资料进行了分析。'锚定'法收集确诊为慢性呼吸道疾病的患者50例,其中男38例,女12例;平均年龄(64.2±12.3)岁,通过电话采访及使用整体变化评估量表(GROC)评价患者肺康复计划后的自觉改善程度,再将患者在肺康复计划中6MWD的改变数值与相对应的患者自觉改善程度进行比较,这种关系用操作特征曲线(ROC)统计表示。通过'分布'法确定6MWD的MCID,从门诊和住院的肺康复计划(PRP)参与者中检索医疗记录136例,其中男103例,女33例;平均年龄(60.1±14.1)岁。结果 :ROC曲线表明6MWD出现临床显著性变化的最佳临界值为17.4 m,其对应的敏感性为79.4%,特异性为81.3%,阳性似然比为4.23。由'分布'法确定6MWD的最小临床重要差异值为18.6 m。结论:18.6 m为新加坡华人6MWD的最小临床重要差异的估计值。 | Meredith T L YEUNG Alan W P WONG Katherine S L HUANG Alice Y M JONES | 2015 | 康复学报2015，25，1： | 3 |
| 3 | Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study显示文摘 | Mark S Pearce Jane A Salotti Mark P Little Kieran McHugh Choonsik Lee Kwang Pyo Kim Nicola L Howe Cecile M Ronckers Preetha Rajaraman Alan W Craft Louise Parker Amy Berrington de González | 2012 | The Lancet . 2012 (9840)2012，，： | 3 |
| 4 | Diagnostic accuracy of tests for Helicobacter pylori in an Alaska Native population显示文摘AIM:To evaluate the accuracy of two non-invasivetests in a population of Alaska Native persons. Highrates of Helico bacter pylori(H. pylori) infection,H. pylori treatment failure,and gastric cancer in this population necessitate documentation of infection status atmultiple time points over a patient's life.METHODS:In 280 patients undergoing endoscopy,H. pylori was diagnosed by culture,histology,rapidurease test,13C urea breath test(UBT) ,and immuno-globulin G antibodies to H. pylori in serum. The performances of 13C-UBT and antibody test were compared to a gold standard defined by a positive H. pylori testby culture or,in case of a negative culture result,bypositive histology and a positive rapid urease test.RESULTS:The sensitivity and specificity of the 13C-UBT were 93% and 88%,respectively,relative to thegold standard. The antibody test had an equivalents ensitivity of 93% with a reduced specificity of 68%.The false positive results for the antibody test were as-sociated with previous treatment for an H. pylori infection [relative risk(RR) = 2.8]. High levels of antibodiesto H. pylori were associated with chronic gastritis and male gender,while high scores in the 13C-UBT testwere associated with older age and with the H. pyloribacteria load on histological examination(RR = 4.4) .CONCLUSION:The 13C-UBT out performed the anti-body test for H. pylori and could be used when a non-invasive test is clinically necessary to document treatment out come or when monitoring for reinfection. | Dana L Bruden Michael G Bruce Karen M Miernyk Julie Morris Debby Hurlburt Thomas W Hennessy Helen Peters Frank Sacco Alan J Parkinson Brian J McMahon | 2011 | World Journal of Gastroenterology2011，17，42： | 3 |
| 5 | Pentoxifylline treatment and penile calcifications in men Nith Peyronie's disease显示文摘 | James F Smith Alan W Shindel Yun-Ching Huang Raul I Clavijo Lawrence Flechner Benjamin N Breyer Michael L Eisenberg Tom F Lue | 2011 | Asian Journal of Andrology2011，13，2： | 2 |
| 6 | Determining Lyapunov Exponents from a Time Series显示文摘 | Alan W Jack B S Harry L S | 1985 | Physica D1985，16，： | 1 |
| 7 | Determination of total aryte- noids and chlorophylls a and b of leaf extracts in differ- ent solvents显示文摘 | Hartmut K L Alan R W | 1983 | Bioche Soc Trans1983，11，： | 1 |
| 8 | Ethanol-diesel fuel blends--A Review 显示文摘 | HANSEN Alan C ZHANG Qin LYNE Peter W L | 2005 | Bioresource Technology2005，96，3： | 1 |
| 9 | Ethanol-diesel fuel blends:A review显示文摘 | Hansen Alan C Zhang Qing Lyne Peter W L | 2005 | Bioresource Technology2005，96，： | 1 |
| 10 | Ethanol-Diesel Fuel Blends-A Review显示文摘 | Hansen Alan C Zhang Qin Lyne Peter W L | 2005 | Bioresource Technology2005，96，3： | 1 |
| 11 | Mercury(11) immobilized on car-bon nanotubes: synthesis, characterization and redox properties 显示文摘 | ALAN M B MIAO W COLIN L R | 2000 | Langmuir2000，16，14： | 1 |
| 12 | Emergence in China of human disease due to avian influenza A(H10N8)-cause for concern显示文摘 | To K K Tsang A K Chan J F Kelvin K W Alan K L | 2014 | J Infect2014，68，： | 1 |
| 13 | Use and efficacy of low close ketamine in the management or acute postoperative pain: a review of current techniques and outcomes显示文摘 | ROGER L S ALAN N S W S JOEL K | 1999 | Pain1999，82，： | 1 |
| 14 | Ethanol-diesel fuel blends: a review显示文摘 | Alan C H Qin Z Peter W L L | 2005 | Bioresource Technology2005，96，3： | 1 |
| 15 | Determining Lyapunov Exponents from a Time Series 显示文摘 | ALAN W SWIFT J B SWINNEY H L | 1985 | Physica1985，16，： | 1 |
| 16 | Micropower impulse radar:a Novel technology for rapid,real-time detection of pneumothorax显示文摘 | Phillip D L Tracey W Alan G | 2011 | Emergency Medicine International2011，，3： | 1 |
| 17 | Evaluation of an alternative IMS dissociation procedure for use with method 1623:detection of Cryptosporidium in water显示文摘 | Ware M W Wymer L Alan Lindquist H D | 2003 | Journal of Microbiological Methods2003，55，： | 1 |
| 18 | Electric-Field Carbon Nanotubes in Different Dielectric Solvents显示文摘 | Liu Xianming Spencer John L Kaiser Alan B Arnold W Mike | 2004 | Current Applied Physics2004，4，： | 1 |
| 19 | National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: Clinical Utilization of Cardiac Biomarker Testing in Heart Failure显示文摘 | W H. Wilson Tang Gary S. Francis David A. Morrow L Kristin Newby Christopher P. Cannon Robert L. Jesse Alan B. Storrow Robert H. Christenson Robert H. Christenson Fred S. Apple Christopher P. Cannon Gary S. Francis Robert L. Jesse David A. Morrow L Kristi | 2007 | Circulation2007，，5： | 1 |
| 20 | Using the Roy Adaptation Model to develop an antenatal assessment instrument显示文摘 | Linda L Alan Y Ka Fai W | 2011 | Nursing Science Quarterly2011，24，4： | 1 |
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