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| 1 | 抗炎介质表达缺陷参与中性粒细胞型支气管哮喘发病机制:半乳糖凝集素-3和白细胞介素-1RA/白细胞介素-1beta比例显著下降显示文摘支气管哮喘(哮喘)是具有异质性的气道炎症性疾病,其主要特点表现为气道高反应和可变的气流受限。在哮喘的发病机制中,过敏原诱导的TH2淋巴细胞激活以及IL-5介导的嗜酸粒细胞渗出起到重要的作用。近年来发现超过50%的哮喘患者气道的嗜酸粒细胞水平并不增高,并将这种亚型定义为非嗜酸粒细胞型哮喘。其中部分患者表现为气道中性粒细胞明显增高,称为中性粒细胞型哮喘。 | 高鹏 Peter G Gibson Katherine J Baines Ian A Yang John W Upham Paul N Reynolds Sandra Hodge Alan L James Christine Jenkins Matthew J Peters 张捷 Jodie L Simpson | 2016 | 中华结核和呼吸杂志2016，39，11： | 5 |
| 2 | Determination of Organically Bound Tritium Background Level in Biological Samples From a Wide Area in the South-west of France显示文摘 | Pointurier F Baglan N Alanic G | 2003 | J Environ Radioact2003，68，： | 2 |
| 3 | Melatonin modifies SOX2^+ cell proliferation in dentate gyrus and modulates SIRT1 and MECP2 in long-term sleep deprivation显示文摘Melatonin is a pleiotropic molecule that,after a short-term sleep deprivation,promotes the proliferation of neural stem cells in the adult hippocampus.However,this effect has not been observed in long-term sleep deprivation.The precise mechanism exerted by melatonin on the modulation of neural stem cells is not entirely elucidated,but evidence indicates that epigenetic regulators may be involved in this process.In this study,we investigated the effect of melatonin treatment during a 96-hour sleep deprivation and analyzed the expression of epigenetic modulators predicted by computational text mining and keyword clusterization.Our results showed that the administration of melatonin under sleep-deprived conditions increased the MECP2 expression and reduced the SIRT1 expression in the dentate gyrus.We observed that let-7 b,mir-132,and mir-124 were highly expressed in the dentate gyrus after melatonin administration,but they were not modified by sleep deprivation.In addition,we found more Sox2^+/5-bromo-2’-deoxyuridine(BrdU)^+cells in the subgranular zone of the sleep-deprived group treated with melatonin than in the untreated group.These findings may support the notion that melatonin modifies the expression of epigenetic mediators that,in turn,regulate the proliferation of neural progenitor cells in the adult dentate gyrus under long-term sleep-deprived conditions.All procedures performed in this study were approved by the Animal Ethics Committee of the University of Guadalajara,Mexico(approval No.CI-16610)on January 2,2016. | Alan Hinojosa-Godínez Luis F. Jave-Suarez Mario Flores-Soto Alma Y. Gálvez-Contreras Sonia Luquín Edith Oregon-Romero Oscar González-Pérez Rocio E. González-Castaneda | 2019 | Neural Regeneration Research2019，14，10： | 2 |
| 4 | Levels of Expression of P-Selectin, E-Selectin, and Intercellular Adhesion Molecule-1 in Coronary Atherectomy Specimens from Patients With Stable and Unstable Angina Pectoris显示文摘 | Alan N Tenaglia MD Andrew J Buda MD Robert G Wilkins MD Michael K Barron MD Paul R Jeffords BS Khoa Vo BS Maureen O Jordan BS Barry A Kusnick MD David J Lefer PhD | 1997 | The American Journal of Cardiology1997，，6： | 1 |
| 5 | Designing climate mitigation policy显示文摘 | Joseph E A Alan J K Richard G N | 2010 | Journal of Economic Literature2010，48，4： | 1 |
| 6 | Self-oriented regular arrays of carbon nanotubes and their field emission properties显示文摘 | FAN S S CHAPLINE M G FRANKIN N R TOMBLER T W ALAN C M DAI H J | 1999 | Science1999，283，： | 1 |
| 7 | Neovascularization in atherect9my specimens from patients with unstable angina显示文摘 | Alan N Kevin G Michael Hs etal | 1998 | Am Heart1998，135，9： | 1 |
| 8 | Hydrogen production from sewage sludge using mixed microflora inoculum: Effect of pH and enzymatic pretreatment显示文摘 | JAIME M N RICHARD D ALAN G | 2008 | Bioresource Technology2008，99，14： | 1 |
| 9 | Comparison of oxygen consumption in freshwater mussels (Unionidae) from different habitats during declining dissolved oxygen concentration 显示文摘 | Chen L Y Alan G H Richard J N | 2001 | Hydrobiologia2001，450，3： | 1 |
| 10 | 显示文摘 | Xia Y N Wiesinger J M Alan G | 1995 | Chem Mater1995，7，： | 1 |
| 11 | Hydrogen production from sewage sludge using mixed microflora inocu- lure:effect of pH and enzymatic pretreatment 显示文摘 | Jaime M N Richard D Alan G | 2008 | Bioresource Techno12008，99，： | 1 |
| 12 | Phase Ⅱ study of sequeutial doublets:topotecan and carboplatin,followed by paclitaxel and carboplatin,in patients with newly diagnosed advanced ovarian cancer显示文摘 | ALAN N G LINA A MARK J M | 2004 | Gynecol Oncol2004，94，： | 1 |
| 13 | Determination of the non exchange-organically bound tritium (NE-OBT) fraction in tree leaf samples collected around a nuclear research een- tre显示文摘 | BAGLAN N MEIGNEN L R ALANIC G | 2008 | Fusion Science and Technology2008，54，1： | 1 |
| 14 | Pyridine- 3-earboxamides as novel CB2 agonists for analgesia 显示文摘 | William M L Gerard G M P Alan N | 2009 | Bioorg Med Chem Lett2009，19，1： | 1 |
| 15 | Relationship of neurovascular compression to central sympathetic discharge and essential hypertension显示文摘 | Paul A Smith James F.M Meaney Lee N Graham John B Stoker Alan F Mackintosh David A.S.G Mary Stephen G Ball | 2004 | Journal of the American College of Cardiology2004，，8： | 1 |
| 16 | Determination of nucleation,agglomeration and disruption kinetics from experimental precipition data:the calcium oxalate system显示文摘 | Rudolf Z N Alan G J | 2000 | Chemical Engineering Science2000，55，： | 1 |
| 17 | Signal transduetion through MAP kinase cascades 显示文摘 | Lewis T S Shapiro P S Alan N G | 1998 | Adv Cancer Res1998，74，： | 1 |
| 18 | Performance Analysis of Closed-Loop Transmit Diversity in the Presence of Feedback Delay显示文摘 | Onggosnusi Eko N Gatherer Alan Dabak Anand G Hosur Srinath | 2001 | IEEE Trans on Communication2001，49，9： | 1 |
| 19 | Neovascularization in atherectomy specimens from patients with unstable angina显示文摘 | Alan N Kevin G Michael Hs | | 0，，： | 1 |
| 20 | Levels of expression of P - selectin, E - selectin, and intercellular adhesion molecule- 1 in coronary atherectomy specimens from patients with stable and unstableangina pectoris 显示文摘 | Alan N Tenaglia Andrew J Buda Robert G | 1997 | Am J Cardiol1997，79，： | 1 |
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