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| 1 | Single nucleotide polymorphism in the tumor necrosis factor-alpha gene affects inflammatory bowel diseases risk显示文摘AIM: To investigate the role that single nucleotide polymorphisms (SNPs) in the promoter of the tumour necrosis factor-alpha (TNF-α) gene play in the risk of inflammatory bowel diseases (IBDs) in a New Zealand population, in the context of international studies. METHODS: DNA samples from 388 patients with Crohn's disease (CD), 405 ulcerative colitis (UC), 27 indeterminate colitis (IC) and 201 randomly selected controls, from Canterbury, New Zealand were screened for 3 common polymorphisms in the TNF-α receptor: -238 G→A, -308 G→A and -857C→T, using a TaqmanR assay. A meta-analysis was performed on the data obtained on these polymorphisms combined with that from other published studies. RESULTS: Individuals carrying the -308 G/A allele had a significantly (OR = 1.91, χ2 = 17.36, P < 0.0001) increased risk of pancolitis, and a 1.57-fold increased risk (OR = 1.57, χ2 = 4.34, P = 0.037) of requiring a bowel resection in UC. Carrying the -857 C/T variant decreased the risk of ileocolonic CD (OR = 0.56, χ2 =4.32, P = 0.037), and the need for a bowel resection (OR = 0.59, χ2 = 4.85, P = 0.028). The risk of UC was reduced in individuals who were smokers at diagnosis, (OR = 0.48, χ2 = 4.86, P = 0.028). CONCLUSION: TNF-α is a key cytokine known to play a role in inflammatory response, and the locus for the gene is found in the IBD3 region on chromosome 6p21, known to be associated with an increased risk for IBD. The -308 G/A SNP in the TNF-α promoter is functional, and may account in part for the increased UC risk associated with the IBD3 genomic region. The -857 C/T SNP may decrease IBD risk in certain groups. Pharmaco- or nutrigenomic approaches may be desir- able for individuals with such affected genotypes. | Lynnette R Ferguson Claudia Huebner Ivonne Petermann Richard B Gearry Murray L Barclay Pieter Demmers Alan McCulloch Dug Yeo Han | 2008 | World Journal of Gastroenterology2008，14，29： | 7 |
| 2 | Randomized trial in malignant biliary obstruction:Plastic vs partially covered metal stents显示文摘AIM:To compare efficacy and complications of par-tially covered self-expandable metal stent(pcSEMS)to plastic stent(PS)in patients treated for malignant,infrahilar biliary obstruction.METHODS:Multicenter prospective randomized clinical trial with treatment allocation to a pcWallstent(SEMS)or a 10 French PS.Palliative patients aged≥18,for infrahilar malignant biliary obstruction and a Karnofsky performance scale index>60%from 6 participating North American university centers.Primary endpoint was time to stent failure,with secondary outcomes of death,adverse events,Karnofsky performance score and short-form-36 scale administered on a three-monthly basis for up to 2 years.Survival analyses were performed for stent failure and death,with Cox proportional hazards regression models to determine significant predictive characteristics.RESULTS:Eighty-five patients were accrued over 37mo,42 were randomized to the SEMS group and 83patients were available for analyses.Time to stent failure was 385.3±52.5 d in the SEMS and 153.3±19.8 d in the PS group,P=0.006.Time to death did not differ between groups(192.3±23.4 d for SEMS vs211.5±28.0 d for PS,P=0.70).The only significant predictor was treatment allocation,relating to the time to stent failure(P=0.01).Amongst other measured outcomes,only cholangitis differed,being more common in the PS group(4.9%vs 24.5%,P=0.029).The small number of patients in follow-up limits longitudinal assessments of performance and quality of life.From an initially planned 120 patients,only 85 patients were recruited.CONCLUSION:Partially covered SEMS result in a longer duration till stent failure without increased complication rates,yet without accompanying measurable benefits in survival,performance,or quality of life. | Peter L Moses Khalid M AlNaamani Alan N Barkun Stuart R Gordon Roger D Mitty M Stanley Branch Thomas E Kowalski Myriam Martel Viviane Adam | 2013 | World Journal of Gastroenterology2013，19，46： | 6 |
| 3 | Use of buffeting and other means to improve results of problem atic pesticides in a fast and easy method for residue analysis of fruits and vegetables 显示文摘 | STEVEN J L KATEIINA M ALAN R L | 2005 | JAOAC Int2005，88，2： | 1 |
| 4 | Competing models of entrepreneurial intentions显示文摘 | Krueger J R Norris F Reilly Michael D and Carsrud Alan L | 2000 | Journal of Business Venturing2000，15，56： | 1 |
| 5 | A test method for wash-off pressure sensitive adhesives显示文摘 | BRYAN D L ALAN D R P | 1996 | International Journal of Adhesion and Adhesives1996，16，1： | 1 |
| 6 | Determination of total aryte- noids and chlorophylls a and b of leaf extracts in differ- ent solvents显示文摘 | Hartmut K L Alan R W | 1983 | Bioche Soc Trans1983，11，： | 1 |
| 7 | Total phenol, flavonoid, proanthocyanidin and vitamin C levels and antioxidant activities of Mauritian vegetables显示文摘 | Theeshan B Amitabye L R Alan C | 2004 | Journal of the Science of Food and Agriculture2004，84，9： | 1 |
| 8 | smith, Determinants of Sport Commitment Among Junior Tennis Players: Enjoyment as a Mediating Variable显示文摘 | Maureen R Weiss Lissa A Kimmel Alan L | 2001 | Pediatric Exercise Science2001，13，： | 1 |
| 9 | Software strategies for portable computer energy management 显示文摘 | Jacob R L Alan J S | 1998 | IEEE Personal Communications1998，5，3： | 1 |
| 10 | 查看详情显示文摘 | Lehotay S J Kate(r)ina M Alan R L | | 0，，02： | 1 |
| 11 | Short bowel syndrome and crohn’s disease显示文摘 | Jon S Thompson Kishore R Iyer John K DiBaise Renee L Young Cindy R Brown Alan N Langnas | 2003 | Journal of Gastrointestinal Surgery2003，，8： | 1 |
| 12 | Creep and microstructure of magnesium-aluminum-calcium based alloys 显示文摘 | Alan A L Michael P B Bob R P | 2002 | Metallurgical and Materials Transactions2002，33，： | 1 |
| 13 | Mercury(11) immobilized on car-bon nanotubes: synthesis, characterization and redox properties 显示文摘 | ALAN M B MIAO W COLIN L R | 2000 | Langmuir2000，16，14： | 1 |
| 14 | Characterization of thematioxidant functions of flavonoids and proan- thocyanidins in Mauritianblack teas显示文摘 | AMITABYE L R THEESHAN B ALAN C | 2005 | Food Research International2005，38，： | 1 |
| 15 | Nighttime blood pressure dipping: the role of the sympathetic nervous system显示文摘 | Andrew Sherwood Patrick R Steffen James A Blumenthal Cynthia Kuhn Alan L Hinderliter | 2002 | American Journal of Hypertension2002，，2： | 1 |
| 16 | Variants of the insulin receptor substrate-1 and fatty acid binding protein 2 genes and the risk of type 2 diabetes, obesity, and hyperinsulinemia in African Americans显示文摘 | Hsien-Hsien L Josef Coresh Alan R | 1999 | Diabetes1999，48，： | 1 |
| 17 | Vertically Unstable Pelvic Fractures Fixed with Percutaneous Iliosacral Screws: Does Posterior Injury Pattern Predict Fixation Failure?显示文摘 | Damian R Griffin Adam J Starr Charles M Reinert Alan L Jones Shelly Whitlock | 2006 | Journal of Orthopaedic Trauma ( Suppl)2006，，1： | 1 |
| 18 | 显示文摘 | KATELINA M ALAN R L | 2005 | J AOAC International2005，88，2： | 1 |
| 19 | Effect of granulocyte-monocyte colony-stimulating factor therapy on leukocyte function and clearance of serious infection in nonneutropenic patients显示文摘 | Alan J R Peter K L Adrienne D | 2005 | Chest2005，127，： | 1 |
| 20 | Microwave pyrolysis,a novel process for recycling waste automotive engine oil显示文摘 | SU S L ALAN D R HOWARD A C | | 0，，35： | 1 |
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