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| 1 | Commercially available probiotic drinks containing Lactobacillus casei DN-114001 reduce antibiotic-associated diarrhea显示文摘AIM:To investigate the effect of Lactobacillus-containing commercially available probiotic formulations in Germany during antibiotic treatment with an analysis of cost-efficiency.METHODS:In an observational study,we analyzed the frequency of bowel movements from 258 patients with infections in a primary care hospital in western Germany;107 of the patients were offered a probiotic drink containing at least 10 billion cultures of Lactobacillus casei DN 114001 b.i.d.The economic analysis was based on the costs of patient isolation vs preventive intake of probiotics.In a second pilot study,two commercially available probiotic drinks with different Lactobacillus casei strains were directly compared in 60patients in a randomized controlled fashion.RESULTS:In the first study,the incidence of antibioticassociated diarrhea(AAD)was significantly reducedin the intervention group(6.5%vs 28.4%),and the duration of AAD in days was significantly shorter(1.7±1.1 vs 3.1±2.1).Higher age and creatinine and lower albumin were identified as risk factors for AAD.Ampicillin was the antibiotic with the highest rate of AAD(50%)and with the greatest AAD reduction in the probiotic group(4.2%,relative risk reduction 92%).The economic analysis showed a cost advantage of nearly60000€/year in a department of this size.The second study confirmed the preventive effect of the drink with Lactobacillus casei DN114001;however,there were no advantages found for the other tested probiotic drink containing Lactobacillus casei Shirota.CONCLUSION:In contrast to a drink containing Lactobacillus casei Shirota,a commercially available probiotic drink containing Lactobacillus casei DN 114001 costefficiently reduces the prevalence of AAD during antibiotic treatment. | Christoph G Dietrich Tanja Kottmann Manuela Alavi | 2014 | World Journal of Gastroenterology2014，20，42： | 14 |
| 2 | 化疗所致恶心呕吐对复发性卵巢癌患者预后的影响:纳入1213例患者数据的meta分析结果显示文摘背景与目的 本研究旨在研究化疗所致恶心呕吐(chemotherapy-induced nausea and vomiting,CINV)对化疗药物剂量减少、中止以及患者生存获益的潜在影响。方法 本研究基于德国东北妇科肿瘤学会(North-Eastern German Society of Gynecological Oncology,NOGGO)开展的3项Ⅱ/Ⅲ期临床试验中的1213例复发性卵巢癌患者的原始数据,进行了个体病例数据的meta分析。通过Logistic回归和Cox回归分析,对年龄、ECOG评分、化疗周期数、复发次数、并发症以及不同研究等因素进行校正后,评估相应的比值比和风险比(hazard ratio,HR)。结果 大多数(58.1%)患者发生了恶心,且近三分之一(31.0%)的患者出现呕吐。CINV的发生与FIGO分期、分级、组织学以及复发次数无关;必须的化疗药物减量和中止化疗与恶心、呕吐的发生亦无相关性(P=0.88,P=0.39;P=0.25,P=0.54)。发生Ⅲ/Ⅳ级恶心呕吐患者的无进展生存期更短(P=0.02,Ⅲ/Ⅳ级恶心的HR=1.58,95%CI:1.14–2.20;P=0.02,Ⅲ/Ⅳ级呕吐的HR=1.67,95%CI:1.15–2.42)。发生Ⅲ/Ⅳ级恶心和呕吐的患者生存期较短(P <0.001,Ⅲ/Ⅳ级恶心的HR=2.35,95%CI:1.64–3.37;P <0.001,Ⅲ/Ⅳ级呕吐的HR=1.67,95%CI:1.15–2.42)。结论 CINV与复发性卵巢癌患者较差的预后显著相关,而与必须的化疗药物减量和中止无相关性。本研究强调CINV防治是早期最佳支持治疗的重要环节。 | Hannah Woopen R Richter R Chekerov G Inci S Alavi J P Grabowski J Sehouli 尹如铁(译) | 2022 | 癌症2022，41，6： | 2 |
| 3 | Charge transport along the λ- DNA显示文摘 | Tran P Alavi B Gruner G | 2000 | Phys Rev Lett2000，85，： | 1 |
| 4 | Non-invasive assessment of postoperative bleeding in TKA patients with Tc-99m RNCs显示文摘 | McManus K T Velehik M G Alavi A | 1987 | J Nuel Med1987，28，1： | 1 |
| 5 | Molecular dynamicsstudies of melting and liquid properties of ammonium dinitramide显示文摘 | Velardez G F Alavi S Thompson D L | 2003 | Journal of Chemical Physics''2003，119，13： | 1 |
| 6 | Information technology and organizational learning:An investigation of exploration and exploitation processes显示文摘 | KANE G C ALAVI M | | 0，，05： | 1 |
| 7 | Information Technology and Organizational Learning:An Investigation of Exploration and Exploitation Processes显示文摘 | Kane G C Alavi M | 2007 | Organization Science2007，18，5： | 1 |
| 8 | Immunohistochemical evidence for ATP receptors in human dental pulp显示文摘 | Alavi AM Dubyak GR Burnstock G | 2001 | J Dent Res2001，80，2： | 1 |
| 9 | Information technology and organizational learning: An investigation of exploration and ex- ploitation processes 显示文摘 | Kane G C Alavi M | 2007 | Organization Science2007，18，5： | 1 |
| 10 | Tunablie fiber bandpass filter based on a linearly chirped fiber Bragg grating for wavelength demultiplexing显示文摘 | XU M G ALAVIE A T MASKANT R | 1996 | Electron Lett1996，32，20： | 1 |
| 11 | A three-dimensional simulation of shot peening process using multiple shot impacts显示文摘 | Majzoobi G H Azizi R Alavi Nia A | | 0，，164： | 1 |
| 12 | Cell survival in a three- dimensional matrix 显示文摘 | ALAVI A STUPACK D G | 2007 | Methods in Enzymology2007，426，： | 1 |
| 13 | Non-inva- sire assessment ofpostoperative bleeding in TKA patientswith Tc-99m RBCs显示文摘 | MacMANUS K T VELCHIK M G ALAVI A | 1987 | J Nucl Med1987，28，： | 1 |
| 14 | Molecular dynamics studies of melting and liquid properties of ammonium dinitramide显示文摘 | Velardez G F Alavi S Thompson D L | 2003 | Journal of Chemical Physics2003，119，13： | 1 |
| 15 | A three dimensional simulation of shot peening process using multiple shot impacts显示文摘 | Majzoobi G H Azizi R Alavi Nia A | 2005 | Journal of Materials Processing Technology2005，16，4165： | 1 |
| 16 | Soil acidification induced by ammonium sulphate addition in a Norway spruce forest in southwest Sweden 显示文摘 | Bergholm J Berggren D Alavi G | 2003 | Water Air and Soil Pollution2003，148，14： | 1 |
| 17 | Information technology and organizational learning: An investigation of exploration and exploitation processes显示文摘 | Kane G C Alavi M | 2007 | Organization Science2007，18，5： | 1 |
| 18 | Information Technology and Organizational Learning- An Investigation of Explo- ration and Exploitation Processes 显示文摘 | KANE G C ALAVI M | 2007 | Organization Science2007，18，5： | 1 |
| 19 | Information Technology and Organizational Learning:An Investigation of Exploration and Exploitation Processes 显示文摘 | Kane G C Alavi M | 2007 | Organization Science2007，，5： | 1 |
| 20 | Non- invasive assessment of postoperative bleeding in TKA patients with Tc-99m RNCs显示文摘 | MCMANUS K T VELCHIK M G ALAVI A | 1987 | J Nuclear Med1987，，： | 1 |
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