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| 1 | Renal denervation as an option for the management of hypertension显示文摘Hypertension is a multifactorial condition which makes the development of treatment approaches difficult.The vast majority of patients are treated with lifestyle measures either alone or in combination with antihypertensive drugs,and this approach is largely successful in controlling blood pressure.However,for a subgroup of patients,control of blood pressure remains resistant to this approach and therefore the development of new strategies is imperative.The sympathetic nervous system has been known to be implicated in hypertension for many decades,and evidence from studies in the past has revealed the benefit of reducing sympathetic nerve activity in the control of blood pressure albeit with severe side effects.Recent technological advances have allowed for specific targeting of the renal sympathetic nerves by catheter ablation.The Symplicity HTN-1 and HTN-2 trials have provided strong evidence for renal denervation giving rise to considerable blood pressure reductions in treatment-resistant hypertensives and,due to the high incidence of hypertension worldwide,this carries the promise of further reducing the global burden of hypertension and its attendant complications.Here we review the evidence for renal denervation in the management of hypertension. | Georgina Radhini Santiapillai Albert Ferro | 2014 | The Journal of Biomedical Research2014，28，1： | 3 |
| 2 | Cardiac effect of amiloride and of enalapril in the spontaneously hypertensive rat显示文摘 | Yong Ji Yah Huang Albert Ferro | 2003 | Journal of Hypertension2003，21，8： | 1 |
| 3 | cAMP产生的兔股动脉舒张部分由NO介导显示文摘目的 :研究cAMP产生的周围血管扩张作用是否与激活一氧化氮合酶 (NOS)有关。方法 :利用家兔股动脉恒流灌注模型 ,观察股动脉内灌注不同浓度的dbcAMP(膜渗透性cAMP)或腺苷酸环化酶的直接激动剂forskolin后灌注压的变化及NOS抑制剂L -NAME对其作用的影响。结果 :dbcAMP和forskolin均产生浓度依赖的周围血管舒张 ,NOS抑制剂L -NAME部分阻断这种作用。结论 :cAMP产生的周围血管扩张作用部分通过激活NOS实现。 | 高玲 徐标 Albert FERRO | 2002 | 中国病理生理杂志2002，18，3： | 1 |
| 4 | Relation between β-adrenoceptor stimulation and nitric oxide synthesis in vascular control显示文摘 | James M. Ritter Albert Ferro Philip J. Chowienczyk | 2006 | European Journal of Clinical Pharmacology2006，，1： | 1 |
| 5 | Phar- maeogenetics of aspirin resistance: a comprehensive systematic review 显示文摘 | Timothy Goodman Albert Ferro Pankaj Sharma | 2008 | British Journal of Clinical Pharmacology2008，，10： | 1 |
| 6 | 维生素C拮抗脂蛋白对兔胸主动脉内皮损伤的保护作用显示文摘目的:探讨非胰岛素依赖型糖尿病(Non-insulin dependent diabetes mellicus,NIDDM)血管并发症的发生枧制及维生素C的保护作用。 方法:观察兔胸主动脉环对乙酰胆碱,钙离子载体A23187的舒张反应,观察NIDDM患者的低密度脂蛋白(low density lipoprotein,LDL)对兔胸主动脉环内皮的损伤作用及维生素C的干预效应。 结果:糖尿病患者LDL浓度依赖性地抑制动脉环对乙酰胆碱及A23187的舒张;维生素C能明显拮抗LDL的损伤作用,但并不能完全逆转;以超氧化物歧化酶(SOD)作为保护药对照,4.17 mkat/L的含量能够显著抑制LDL对内皮的损伤。 结论:糖尿病患者LDL可能通过影响钙内流而抑制一氧化氮合酶 (NOS)活性,并使一氧化氮被氧负离子(O^-)结合增多降低一氧化氮含量,抑制内皮源性舒张;维生素C的抗氧化作用具有内皮保护作用。 | 刁建欣 韩艺 黄艳 许逸 季勇 Albert Ferro | 2004 | 中国临床康复2004，8，9： | 0 |
| 7 | Increased inflammatory cell infiltration and matrix metalloproteinase-1 expression in atherosclerotic plaque of diabetic rabbits显示文摘Objective The aim of the present study was to examine levels of inflammatory cell infiltration and matrix metalloproteinase (MMP)-1 expression in atherosclerotic plaques of diabetic rabbits. Methods Diabetes was induced in rabbits by alloxan injection, and atherosclerotic plaque formation was stimulated both in diabetic and non-diabetic (sham-injected) rabbits by balloon injury of the abdominal aorta together with high lipid feeding. The morphology of atherosclerosis thus generated was studied by angiography and intravascular ultrasound (IVUS). Transverse sections of diseased aorta were examined by immunohistochemistry to analyze numbers of macrophages and smooth muscle cells as well as expression of MMP-1. | Albert FERRO | 2007 | 上海医学2007，30，S1： | 0 |
| 8 | 氨氯地平通过激肽系统的介导引起家兔股动脉释放NO显示文摘目的 研究氨氯地平引起NO释放的机制是否与激肽系统有关。方法 利用家兔股动脉恒流灌注模型 ,观察股动脉内灌注有效浓度的氨氯地平后灌注压及血液中NO代谢产物浓度的变化 ,以及缓激肽B2 受体阻断剂hoe14 0对其作用的影响。结果 氨氯地平缓慢平稳降低周围血管阻力 ,伴有血液中NO代谢产物浓度的升高 ,hoe14 0能部分阻断这种作用。 | 李晓宏 徐标 姚康 Albert FERRO | 2003 | 徐州医学院学报2003，23，4： | 0 |
| 9 | 本校近期发表IF≥4.0的SCI论文摘要(英文)——Aspirin acetylates nitric oxide synthase type 3 in platelets thereby increasing its activity显示文摘 | Xie Liping Liu Zhen Ji Yong O'Kane Peter Jackson Graham Queen Lindsay Ferro Albert | 2009 | 南京医科大学学报(自然科学版)2009，29，9： | 0 |
| 10 | Impaired endothelial progenitor cells mobilization: a novel concept for reduce post-ischemia neovascularization in diabetes显示文摘Objective The aim of the present study was to explore potential mechanism underlying reduced basal circulating endothelial progenitor cells (EPCs) in diabetes, and to determine how diabetes impairs ischemia-induced mobilization of bone marrow-derived EPCs. Methods Circulating c-Kit+/Sca-1+/flk-1+ EPCs and CD31bright/Annexin V+ endothelial microparticles (EMPs) were analyzed by flow cytometry in control and streptozotocin-induced diabetic C57BL/6 mice. Results Compared with nondiabetic controls, diabetic mice had lower level of circulating EPCs, higher level of plasma EMPs, and increased ratio of EMPs to EPCs. Circulating EMPs count and EPCs level were negatively associated with each other. In a hindlimb ischemia model, diabetes suppressed bone marrow-derived EPCs mobilization, accompanied by insufficient upregulaiton of vascular endothelial growth factor (VEGF) and over-activation of matrix metalloproteinases (MMPs) system. As a consequence, diabetic mice showed deficient increase of capillary density and hampered restoration of transcutaneous oxygen pressure (tcpO2) in the ischemic tissue.Concluslon These results suggest that lower circulating EPCs level detected in diabetes may be partly attributed to consumptive loss of EPCs due to increased endothelial damage. Impairment in ischemia-induced EPCs mobilization presents a novel mechanism for defective post-ischemia neovascularization in diabetes. | Albert FERRO | 2007 | 上海医学2007，30，S1： | 0 |
| 11 | 氨氯地平产生的兔股动脉舒张部分由NO介导显示文摘目的 研究氨氯地平舒张周围血管的作用是否与激活一氧化氮合酶 (NOS)有关。方法 利用家兔股动脉恒流灌注模型 ,观察股动脉内灌注有效浓度的氨氯地平后灌注压的变化及NOS抑制剂L NAME对其作用的影响。结果 氨氯地平缓慢平稳降低周围血管阻力 ,NOS抑制剂L NAME能部分阻断这种作用。结论 氨氯地平产生的周围血管舒张作用部分通过刺激NO生成而实现。 | 高玲 徐标 李晓宏 Albert FERRO | 2001 | 高血压杂志2001，9，4： | 0 |
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