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| 1 | Presacral venous bleeding during mobilization in rectal cancer显示文摘AIM To analyze the anatomy of sacral venous plexus flow, the causes of injuries and the methods for controlling presacral hemorrhage during surgery for rectal cancer.METHODS A review of the databases MEDLINE? and Embase? was conducted, and relevant scientific articles published between January 1960 and June 2016 were examined. The anatomy of the sacrum and its venous plexus, as well as the factors that influence bleeding, the causes of this complication, and its surgical management were defined.RESULTS This is a review of 58 published articles on presacral venous plexus injury during the mobilization of the rectum and on techniques used to treat presacral venous bleeding. Due to the lack of cases published in the literature, there is no consensus on which is the best technique to use if there is presacral bleeding during mobilization in surgery for rectal cancer. This review may provide a tool to help surgeons make decisions regarding how to resolve this serious complication.CONCLUSION A series of alternative treatments are described; however, a conventional systematic review in which optimal treatment is identified could not be performed because few cases were analyzed in most publications. | Jose Enrique Casal Núnez Vincenzo Vigorita Alejandro Ruano Poblador Ana María Gay Fernández Maria ángeles Toscano Novella Nieves Cáceres Alvarado Lucinda Pérez Dominguez | 2017 | World Journal of Gastroenterology2017，23，9： | 4 |
| 2 | Plant protection and growth stimulation by microorganisms: biotechnological applications of Bacilli in agriculture显示文摘 | Alejandro Pérez-García Diego Romero Antonio de Vicente | 2010 | Current Opinion in Biotechnology2010，，2： | 2 |
| 3 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 4 | Analysis of orthopedic surgical procedures in children with cerebral palsy显示文摘BACKGROUND Orthopedic surgery in children with cerebral palsy(CP)aims to improve function and prevent deformities.Each child’s condition in CP is unique and many covariables influence surgical decision-making including a patient's age and their functional level.Little is known about the frequency of different types of orthopedic surgery in children with CP who have varied functional levels,particularly in countries from Latin America.AIM To assess the type of orthopedic surgical procedures in relation to age and gross motor function in children with CP.METHODS This retrospective study included all children with CP(n=245)treated with elective orthopedic surgery at a Uruguayan university hospital between October 2010 and May 2016 identified from a surgical database.Eighteen children(7%)were lost to follow-up due to missing medical charts.Demographics,gross motor function classification(GMFCS),and orthopedic surgeries were obtained from the medical records of 227 children.Chi-squared tests and analysis of variance were used to assess the frequency of surgery,accounting for GMFCS levels.Mean age for soft tissue vs bone surgery was compared with the independent samples t-test.RESULTS A total of 711 surgical procedures were performed between 1998 and 2016.On average,children had 3.1 surgical procedures and the mean age at first surgery was 8.0 years.There were no significant differences in age at first surgery among GMFCS levels(P=0.47).The most common procedures were lower leg soft tissue surgery(n=189,27%),hip tenotomy(n=135,19%),and hamstring tenotomy(n=104,14%).For children with GMFCS level Ⅰ,the mean number of surgeries per child[1.8(range 1-9)]differed significantly at P<0.05 in children with GMFCS levels Ⅱ[3.2(1-12)],Ⅲ[3.2(1-8)],Ⅳ[3.3(1-13)],and Ⅴ[3.6(1-11)].Within Ⅱ,Ⅲ,Ⅳ,and Ⅴ,there was no significant difference in mean number of surgeries per child when comparing across the groups.The proportion of soft tissue surgery vs bone surgery was higher in GMFCS levels Ⅰ-Ⅲ(80%-85%)compared to levels IV(68%)and V(55%)(P<0.05).CONCLUSION The frequency of surgical procedures per child did not increase with higher GMFCS level after level Ⅰ.However,the proportion of bone surgery was higher in GMFCS levels Ⅳ-Ⅴ compared to Ⅰ-Ⅲ. | Ignacio Rehbein Viviana Teske Ignacio Pagano Alejandro Cúneo María Elena Pérez Johan von Heideken | 2020 | World Journal of Orthopedics2020，11，4： | 2 |
| 5 | Gut microbiota disturbance during antibiotic therapy: a multi-omic approach显示文摘 | Ana Elena Pérez-Cobas María José Gosalbes Anette Friedrichs Henrik Knecht Alejandro Artacho Kathleen Eismann Wolfgang Otto David Rojo Rafael Bargiela Martin von Bergen Sven C Neulinger Carolin D?umer Femke-Anouska Heinsen Amparo Latorre Coral Barbas Jana | 2013 | Gut2013，，11： | 2 |
| 6 | Educational data mining: A survey and a data mining-based analysis of recent works显示文摘 | ALEJANDRO P A | 2014 | Expert Systems with Applications2014，41，4： | 1 |
| 7 | Reversion of deleterious effects of salt stress by activation of ROS detoxifying enzymes via foliar application of 24-epibrassinolide in rice seedlings显示文摘 | Yanelis R G Lisbel M G José D A Miriam N Alejandro J P | 2015 | Theoretical and Experimental Plant Physiology2015，27，1： | 1 |
| 8 | Molecular biology in breast cancer:intrinsic subtypes and signaling pathways显示文摘 | Eroles P Bosch A Alejandro Pérez-Fidalgo J | | 0，，06： | 1 |
| 9 | Correlation between ammonia levels and the severity of hepatic encephalopathy显示文摘 | Janus P Ong Anjana Aggarwal Derk Krieger Kirk A Easley Matthew T Karafa Frederick Van Lente Alejandro C Arroliga Kevin D Mullen | 2003 | The American Journal of Medicine2003，，3： | 1 |
| 10 | Molecular biology in breast cancer: Intrinsic subtypes and signaling pathways 显示文摘 | Eroles P Bosch A Alejandro Perez-Fidalgo J | 2012 | Cancer Treat Rev2012，38，6： | 1 |
| 11 | Lalanyl-L-glutamine-supplemented parenteral nutrition improves infectious morbidity in secondary peritonitis显示文摘 | CLOTILDE F O ROBERTO A P ALEJANDRO G O | 2004 | Clin Nutr2004，23，1： | 1 |
| 12 | Transformation of undomesticated strains of Bacillus subtilis by protoplast eleetroporation显示文摘 | Diego R A Alejandro P G Jan W V | 2006 | J Mierobiol Methods2006，66，： | 1 |
| 13 | Improved Outcomes for Rectal Cancer in the Era of Preoperative Chemoradiation and Tailored Mesorectal Excision: A Series of 338 Consecutive Cases显示文摘 | Pacelli Fabio Sanchez Alejandro M Covino Marcello Tortorelli Antonio P Bossola Maurizio Valentini Vincenzo Gambacorta Maria A Doglietto Giovanni B | 2013 | The American Surgeon2013，，2： | 1 |
| 14 | Synthesis of camphene from α-pinene using SO3^2- functionalized MCM-41 as catalyst 显示文摘 | Roman A M Gochi Y P Alejandro R S | 2008 | Applied Catalysis A : General2008，334，12： | 1 |
| 15 | Transformation of undomesticated strains of Bacillus subtilis by protoplast electroporation显示文摘 | Diego Romero Alejandro Pérez-García Jan-Willem Veening Antonio de Vicente Oscar P. Kuipers | 2006 | Journal of Microbiological Methods2006，，3： | 1 |
| 16 | Notch Signaling Is Essential for Ventricular Chamber Development显示文摘 | Joaquín Grego-Bessa Luis Luna-Zurita Gonzalo del Monte Victoria Bolós Pedro Melgar Alejandro Arandilla Alistair N. Garratt Heesuk Zang Yoh-suke Mukouyama Hanying Chen Weinian Shou Esteban Ballestar Manel Esteller Ana Rojas José María Pérez-Pomares José Lu | 2007 | Developmental Cell2007，，： | 1 |
| 17 | Increased Orocecal Transit Time in Patients with Nonalcoholic Fatty Liver Disease显示文摘 | Alejandro Soza MD Arnoldo Riquelme MD Robinson González MD Manuel Alvarez MD Rosa María Pérez-ayuso MD Juan Carlos Glasinovic MD Marco Arrese MD | 2005 | Digestive Diseases and Sciences2005，，6： | 1 |
| 18 | Current Phenomenological Know-How and Modeling of Emulsion Inversion显示文摘 | Salager J L Márquez L Alejandro A P | 2000 | Ind Eng Chem Res2000，39，8： | 1 |
| 19 | Protective effects of melatonin in reducing oxidative stress and in preserving the fluidity of biological membranes: a review显示文摘 | Joaquín J. García Laura López‐Pingarrón Priscilla Almeida‐Souza Alejandro Tres Pilar Escudero Francisco A. García‐Gil Dun‐Xian Tan Russel J. Reiter Jose M. Ramírez Milagros Bernal‐Pérez | 2014 | J Pineal Res2014，，3： | 1 |
| 20 | Protective effects of melatonin in reducing oxidative stress and in preserving the fluidity of biological membranes: a review显示文摘 | Joaquín J. García Laura López‐Pingarrón Priscilla Almeida‐Souza Alejandro Tres Pilar Escudero Francisco A. García‐Gil Dun‐Xian Tan Russel J. Reiter Jose M. Ramírez Milagros Bernal‐Pérez | 2014 | J. Pineal Res2014，，3： | 1 |
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