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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Gapped BLAST and PSI-BLAST: a new generation of protein database search programs显示文摘 | Altschul S F Thomas L M Alejandro A S | 1997 | Nucleic Acids Res1997，25，17： | 1 |
| 3 | Functional neurogenesis in hippocampus显示文摘 | HENRIETTE V P ALEJANDRO F S BRAIN R C | 2002 | Nature2002，415，： | 1 |
| 4 | Gapped BLAST and PSI-BLAST:a new generation of protein database search programs 显示文摘 | Stephen F Thomas L M Alejandro A S Jinghui Zhang Zheng Zhang Webb M David J L | 1997 | Nucleic Acids Res1997，25，17： | 1 |
| 5 | Gapped blast and psi - blast : a new generation of protein databases and search programs 显示文摘 | Ahschul S F Madden TL Alejandro A S | 1997 | Nucleic Acids Res1997，25，： | 1 |
| 6 | Gapped BLAST and PSI-BLAST: a new generation of protein database search programs 显示文摘 | Stephen F A Thomas L M Alejandro A S | 1997 | Nucleic Acids Res1997，25，： | 1 |
| 7 | Disturbance changes arbuacular mycorrbizal fungal phenology and soil glomalin concentrations but not fungal spore composition inmontane rainforests in Veracruz and Chiapas,Mexico显示文摘 | Violi H A Alejandro F Wright S F | 2008 | Forest Ecology and Management2008，254，27： | 1 |
| 8 | Gapped BLAST and PSI-BLAST:a new generation of protein database search programs显示文摘 | Altschul S F Madden T L Alejandro A S | 1997 | Nucleic Acids Research1997，25，17： | 1 |
| 9 | Assessing implications of land - use and land - cover change dynamics for conservation of a highly diverse tropical rain forest 显示文摘 | Alejandro F S Miguel M R Omar R M | 2007 | Biological Conservation2007，138，12： | 1 |
| 10 | Assessing implications of land-use and land-cover change dynamics for conservation of a highly diverse tropical rain forest 显示文摘 | ALEJANDRO F S MIGUEL M R OMAR R M | 2007 | Biological Conservation2007，138，12： | 1 |
| 11 | Disturbance changes arbuscular mycorrhizal fungal phenology and soil glomalin concentrations but not fungal spore composition in montane rainforests in Veracruz and Chiapas,Mexico显示文摘 | Violi H A Alejandro F Wright S F | 2008 | Forest Ecology and Management2008，254，： | 1 |
| 12 | Gapped BLAST and PSI-BLAST: a new generation of protein database search programs 显示文摘 | Altschul S F Thomas L M Alejandro A | 1997 | Nucl Acids Res1997，25，： | 1 |
| 13 | Gapped BLAST and PSI-BLAST:a new generation of protein database search programs显示文摘 | Stephen F A Thomas L M Alejandro A S | | 0，，17： | 1 |
| 14 | Assessing implications of land-use and land-cover change dynamics for conservation of a highly diverse tropical rain forest 显示文摘 | Alejandro F S Miguel M R Omar R M | 2007 | Biological Conserva-tion2007，138，12： | 1 |
| 15 | Functional neurogenesis in hippocampus 显示文摘 | Henriette V P Alejandro F S Brian R C | 2002 | Nature2002，415，1： | 1 |
| 16 | Gapped BLAST and PSI-LAST: a new generation of protein database search program 显示文摘 | Altschul S F Thomas L M Alejandro A | 1997 | Nucl Acids Res1997，25，： | 1 |
| 17 | Immunomodulatory oligonucleotide IMT504:Effects on mesenchymal stem cells as a first-in-class immunoprotective/immunoregenerative therapy显示文摘The immune responses of humans and animals to insults(i.e., infections, traumas, tumoral transformation and radiation) are based on an intricate network of cells and chemical messengers. Abnormally high inflammation immediately after insult or abnormally prolonged proinflammatory stimuli bringing about chronic inflammation can lead to life-threatening or severely debilitating diseases. Mesenchymal stem cell(MSC) transplant has proved to be an effective therapy in preclinical studies which evaluated a vast diversity of inflammatory conditions. MSCs lead to resolution of inflammation, preparation for regeneration and actual regeneration, and then ultimate return to normal baseline or homeostasis. However, in clinical trials of transplanted MSCs, the expectations of great medical benefit have not yet been fulfilled. As a practical alternative to MSC transplant, a synthetic drug with the capacity to boost endogenous MSC expansion and/or activation may also be effective. Regarding this, IMT504, the prototype of a major class of immunomodulatory oligonucleotides, induces in vivo expansion of MSCs, resulting in a marked improvement in preclinical models of neuropathic pain, osteoporosis, diabetes and sepsis. IMT504 is easily manufactured and has an excellent preclinical safety record. In the small number of patients studied thus far, IMT504 has been well-tolerated, even at very high dosage. Further clinical investigation is necessary to demonstrate the utility of IMT504 for resolution of inflammation and regeneration in a broad array of human diseases that would likely benefit from an immunoprotective/immunoregenerative therapy. | Jorge Zorzopulos Steven M Opal Andrés Hernando-Insúa Juan M Rodriguez Fernanda Elías Juan Fló Ricardo A López Norma A Chasseing Victoria A Lux-Lantos Maria F Coronel Raul Franco Alejandro D Montaner David L Horn | 2017 | World Journal of Stem Cells2017，9，3： | 1 |
| 18 | Gapped blast and psi-blast:a new generation of protein databases and search programs显示文摘 | Altschul S F Madden T L Alejandro A S | 1997 | Nucleic Acids Res1997，25，17： | 1 |
| 19 | Resistant Starch-rich Powders Prepared by Auto claving of Native and Lintnerized Banana Starch:Partial Characterization显示文摘 | Alejandro A S Emmanuel F H Juscelino T | 2005 | Starch/Starke2005，57，： | 1 |
| 20 | BLAST and PSI-BLAST:a new generation of protein database search programs显示文摘 | STEPHEN F A THOMAS L M ALEJANDRO A S | 1997 | Nucleic Acids Research1997，25，17： | 1 |
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