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| 1 | Non-invasive tests for the prediction of primary hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is one of the most common malignancies in the world and it is one of the main complications of cirrhosis and portal hypertension.Even in the presence of a well-established follow-up protocol for cirrhotic patients,to date poor data are available on predictive markers for primary HCC occurrence in the setting of compensated advanced chronic liver disease patients(cACLD).The gold standard method to evaluate the prognosis of patients with cACLD,beyond liver fibrosis assessed with histology,is the measurement of the hepatic venous pressure gradient(HVPG).An HVPG≥10 mmHg has been related to an increased risk of HCC in cACLD patients.However,these methods are burdened by additional costs and risks for patients and are mostly available only in referral centers.In the last decade increasing research has focused on the evaluation of several,simple,non-invasive tests(NITs)as predictors of HCC development.We reviewed the currently available literature on biochemical and ultrasound-based scores developed for the noninvasive evaluation of liver fibrosis and portal hypertension in predicting primary HCC.We found that the most reliable methods to assess HCC risk were the liver stiffness measurement,the aspartate aminotransferase to platelet ratio index score and the fibrosis-4 index.Other promising NITs need further investigations and validation for different liver disease aetiologies. | Giovanni Marasco Antonio Colecchia Giovanni Silva Benedetta Rossini Leonardo Henry Eusebi Federico Ravaioli Elton Dajti Luigina Vanessa Alemanni Luigi Colecchia Matteo Renzulli Rita Golfieri Davide Festi | 2020 | World Journal of Gastroenterology2020，26，24： | 8 |
| 2 | Spleen stiffness mirrors changes in portal hypertension after successful interferon-free therapy in chronic-hepatitis C virus patients显示文摘AIM To investigate changes in spleen stiffness measurements(SSMs) and other non-invasive tests(NITs) after treatment with direct-acting antivirals(DAAs) and identify predictors of SSM change after sustainedvirological response(SVR). METHODS We retrospectively analysed 146 advanced-chronic liver disease(ACLD) patients treated with DAA with available paired SSM at baseline and SVR24. Liver stiffness(LSM), spleen diameter(SD), platelet count(PLT) and liver stiffness-spleen diameter to platelet ratio score(LSPS) were also investigated. LSM ≥ 21 k Pa was used as a cut-off to rule-in clinically significant portal hypertension(CSPH). SSM reduction > 20% from baseline was defined as significant.RESULTS SSM significantly decreased at SVR24, in both patients with and without CSPH; in 44.8% of cases, SSM reduction was > 20%. LSPS significantly improved in the entire cohort at SVR24; SD and PLT changed significantly only in patients without CSPH. LSM significantly decreased in 65.7% of patients and also in 2/3 patients in whom SSM did not decrease. The independent predictor of decreased SSM was median relative change of LSM. CSPH persisted in 54.4% patients after SVR. Delta LSM and baseline SSM were independent factors associated with CSPH persistence.CONCLUSION SSM and other NITs significantly decrease after SVR, although differently according to the patient's clinical condition. SSM faithfully reflects changes in portal hypertension and could represent a useful NIT for the follow-up of these patients. | Federico Ravaioli Antonio Colecchia Elton Dajti Giovanni Marasco Luigina Vanessa Alemanni Mariarosa Tamè Francesco Azzaroli Stefano Brillanti Giuseppe Mazzella Davide Festi | 2018 | World Journal of Hepatology2018，10，10： | 3 |
| 3 | Model-based definition design in the product lifecycle management scenario显示文摘 | Alemanni M Destefanis F Vezzetti E | 2011 | International Journal Advanced Manufacture Technology2011，52，： | 1 |
| 4 | Model-based definition design in the product lifecycle management scenario显示文摘 | ALEMANNI M Destefanis F Vezzetti E | 2011 | International Journal of Advanced Manufacturing Technology2011，52，14： | 1 |
| 5 | Mortality and functional outcomes of pelvic insufficiency fractures in older patients显示文摘 | Taillandier J Longue F Alemanni M | 2003 | Joint Bone Spine2003，70，4： | 1 |
| 6 | Model-based definition design in the product lifecycle management scenario显示文摘 | Alemanni M Destefanis F Vezzetti E | | 0，，： | 1 |
| 7 | Model-based definition design in the product lifecycle management scenario显示文摘 | Alemanni M Destefanis F Vezzetti E | 2011 | International Journal of Advanced Manufacturing Technology2011，52，3： | 1 |
| 8 | Mortality and function outcomes of pelvic insuffiCiency fractures in older patients显示文摘 | Taillandier J Langue F Alemanni M | 2003 | Joint Bone Spine2003，70，4： | 1 |
| 9 | Model-based definition design in the product lifecycle management scenario显示文摘 | Alemanni M Destefanis E Ve77etti E | 2010 | International Journal of Advanced Manufacturinz Technology2010，，： | 1 |
| 10 | Model- based definition design in the product lifecycle management scenario 显示文摘 | ALEMANNI M DESTEFANIS F VEZZETTI E | 2011 | International Journal of Advanced Manufactur- ing Technology2011，52，1234： | 1 |
| 11 | Mortality and functional outcomes of pelvic insufficiency fractures in older patients 显示文摘 | Taillandier J Langue F Alemanni M | 2003 | Joint Bone Spine2003，70，： | 1 |
| 12 | Modeel-based definition design in the product lifecycle management scenario显示文摘 | ALEMANNI M DESTEFANIS F VEZZETTI E | 2011 | International Journal of Advanced Manufacturing Technology2011，52，14： | 1 |
| 13 | Model-based Defini- tion Design in the Product Lifecycle Management Scenario 显示文摘 | Alemanni M Destefanis F E | 2009 | International Journal of Advanced Manufacturing Technology2009，，： | 1 |
| 14 | Mortality and functional outcomes of pelvic insufficiency fractures in older patients 显示文摘 | Taillandier J Langue F Alemanni M | 2003 | Joint Bone Spine2003，4，： | 1 |
| 15 | Mortality and functional outcomes of pelvic insufficiency fractures in older patients显示文摘 | Taillandier J Langue F Alemanni M | 2003 | Joint Bone Spine2003，70，4： | 1 |
| 16 | Model-based definition design in the product lifecycle management scenario显示文摘 | Alemanni M Destefanis F Vezzetti E | | 0，，1： | 1 |
| 17 | Model-based definition design in the product lifecycle management scenario 显示文摘 | Alemanni M Destefanis F Vezzetti E | 2011 | International Journal of Advanced Manu- facturing Technology2011，52，1234： | 1 |
| 18 | Mortality and functional outcomes of pelvic insufficiency fractures in older patients显示文摘 | Taillandier J Langue F Alemanni M | 2003 | Joint Bone Spine2003，70，4： | 1 |
| 19 | Model- based definition design in the product lifecycle management scemrio显示文摘 | ALEMANNI M DESTEFANIS F VEZZEVFI E | 2011 | The International Journal of Advanced Manu- facting Technology2011，52，4： | 1 |
| 20 | Model-based definition design in the product lifecycle management scenario显示文摘 | ALEMANNI M DESTEFANIS F VEZZETTI E | 2011 | The International Journal of Advanced Manufacturing Technology2011，52，14： | 1 |
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