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| 1 | Mortality of therapeutic fish Garra rufa caused by Aeromonas sobria显示文摘Objective:To investigate a case of mass mortality of Garra rufa(G.rufa)from a fish hatchery farm in Slovakia.Methods:Causative bacterial agent was swabbing out of affected fish skin area and subsequently identified using commercial test system.Antibiotic susceptibility was determined by the disk diffusion method.Results:Infected G.rufa was characterized by abnormal swimming behaviour,bleeding of skin lesions and local haemorrhages.Despite of using recommended aquatic antibiotic treatment no improvement was achieved and Aeromonas sobria{A.sobria)was identified as a causative agent of fish mortality.Due to massive fish mortality,antibiotic susceptibility of pure isolated culture of A.sobria was evaluated employing eight antibiotics against human infections.A.sobria was resistant only against one antibiotic,namely ampicilin.Conclusions:These results indicate that A.sobria can act as a primary pathogen of G.rufa and may be a potential risk factor for immunodeficient or immunoincompetent patients during the ichthyotherapy. | Juraj Majtán Jaroslav erny Alena Ofúkaná Peter Taká Milan Kozánek | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，2： | 3 |
| 2 | Development of soil microbial properties in topsoil layer during spontaneous succession in heaps after brown coal miningin relation to humus mierostructure development 显示文摘 | Jan F Alena N | 2005 | Geoderma2005，129，12： | 1 |
| 3 | Unlocking the relationship of biotic integrity of impaired waters to anthropogenic stresses显示文摘 | Vladimir N Alena B Neal O | 2005 | Water Research2005，39，： | 1 |
| 4 | Unusual conformation of the SxN motif in the crystal structure of penicillin-binding protein A from Mycobacterium tuberculosis显示文摘 | Alena F Robert A N Christopher D | 2010 | J Mol Biol2010，398，： | 1 |
| 5 | Successful eradi- cation of established peritoneal ovarian tumors in SCID-Beige mice following adoptive transfer of T cells genetically targeted to the MUC16 antigen 显示文摘 | Alena AC Thapi DR Yan N | 2010 | Clin Cancer Res2010，16，14： | 1 |
| 6 | Transforming growth factor-bata plasma dynamics and post-irradation lung injury in lung cancer patients 显示文摘 | Alena N J Mike M G | 2004 | Radiotherapy Oncology2004，71，： | 1 |
| 7 | Effect of quantum therapy on pork quality显示文摘In this study the impact of quantum therapy on meat quality of slaughtered pigs was investigated.For this purpose the pigs were treated with different doses of magnet-infrared-laser(MIL) radiation.Animals were divided into four groups according to radiation doses(4096,512,and 64 Hz,and control without application),which were applied in the lumbar area of musculus longissimus dorsi(loin) at various time intervals prior to the slaughter(14 d,24 h,and 1 h).Animals were slaughtered and the meat quality was evaluated by determining of pH value(1,3,and 24 h post slaughter),drip loss,colour,and lactic acid and phosphoric acid amounts.MIL therapy can be used in various fields of veterinary medicine as are surgery and orthopaedics,internal medicine,dentistry,pulmonology,gastroenterology,gynaecology,urology,nephrology,and dermatology.The results achieved showed that MIL radiation used in a short period before slaughter(1 h) can cause a change in the meat quality,as reflected by the non-standard development of pH values,increases in drip loss,and changes of meat colour. | Martin BODNáR Jozef NAGY Peter POPELKA Beáta KORéNEKOVá Ján MAANGA Alena NAGYOVá | 2011 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2011，12，11： | 0 |
| 8 | Interaction of Diet/Lifestyle Intervention and TCF7L2 Genotype on Glycemic Control and Adiposity among Overweight or Obese Adults:Big Data from Seven Randomized Controlled Trials Worldwide显示文摘Objective.The strongest locus which associated with type 2 diabetes(T2D)by the common variant rs7903146 is the transcription factor 7-like 2 gene(TCF7L2).We aimed to quantify the interaction of diet/lifestyle interventions and the genetic effect of TCF7L2 rs7903146 on glycemic traits,body weight,or waist circumference in overweight or obese adults in several randomized controlled trials(RCTs).Methods.From October 2016 to May 2018,a large collaborative analysis was performed by pooling individualparticipant data from 7 RCTs.These RCTs reported changes in glycemic control and adiposity of the variant rs7903146 after dietary/lifestyle-related interventions in overweight or obese adults.Gene treatment interaction models which used the genetic effect encoded by the allele dose and common covariates were applicable to individual participant data in all studies.Results.In the joint analysis,a total of 7 eligible RCTs were included(n=4,114).Importantly,we observed a significant effect modification of diet/lifestyle-related interventions on the TCF7L2 variant rs7903146 and changes in fasting glucose.Compared with the control group,diet/lifestyle interventions were related to lower fasting glucose by-3.06(95%CI,-5.77 to-0.36)mg/dL(test for heterogeneity and overall effect:I^(2)=45:1%,p<0:05;z=2:20,p=0:028)per one copy of the TCF7L2 T risk allele.Furthermore,regardless of genetic risk,diet/lifestyle interventions were associated with lower waist circumference.However,there was no significant change for diet/lifestyle interventions in other glycemic control and adiposity traits per one copy of TCF7L2 risk allele.Conclusions.Our findings suggest that carrying the TCF7L2 T risk allele may have a modestly greater benefit for specific diet/lifestyle interventions to improve the control of fasting glucose in overweight or obese adults. | Tao Huang Zhenhuang Zhuang Yoriko Heianza Dianjianyi Sun Wenjie Ma Wenxiu Wang Meng Gao Zhe Fang Emilio Ros Liana C.Del Gobbo Jordi Salas-Salvadó Miguel A.Martínez-González Jan Polak Markku Laakso Arne Astrup Dominique Langin Jorg Hager Gabby Hul Torben Hansen Oluf Pedersen Jean-Michel Oppert Wim H.M.Saris Peter Arner Montserrat Cofán Sujatha Rajaram Jaakko Tuomilehto Jaana Lindström Vanessa D.de Mello Alena Stancacova Matti Uusitupa Mathilde Svendstrup Thorkild I.A.Sørensen Christopher D.Gardner Joan Sabaté Dolores Corella J.Alfredo Martinez Lu Qi | 2021 | Health Data Science2021，，1： | 0 |
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