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| 1 | Muscle RING-finger protein-1 (MuRFl) functions and cellular localization are regulated by SUMOl post-translational modification显示文摘The muscle RING-finger protein-1 (MuRFl) is an E3 ubiquitin ligase expressed in skeletal and cardiac muscle tissues and it plays important roles in muscle remodeling. Upregulation of MuRFl gene transcription participates in skeletal muscle atrophy, on contrary downregulation of protein expression leads to cardiac hypertrophy. MuRFl gene point mutations have been found to generate protein aggregate myopathies defined as muscle disorder characterized by protein accumulation in muscle fibers. We have discovered that MuRFl turned out to be also a target for a new post-translational modification arbitrated by conjugation of SUM01 and it is mediated by the SUMO ligases E2 UBC9 and the E3 PIASy/4. SUMOylation takes place at lysine 238 localized at the second coiled-coil protein domain that is required for efficient substrate interaction for polyubiquitination. We provided evidence that SUMOylation is essential for MuRFl nuclear translocation and its mitochondria accumulation is enhanced in hyper? glycemic conditions delivering a stabilization of the overall SUMOylated proteins in cultured myocytes. Thus, our findings add this SUM01 post-translational modification as a new concept to understand muscle disorders related to the defect in MuRFl activity. | Gabriel Heras Arvind Venkat Namuduri Leonardo Traini Ganna Shevchenko Alexander Falk Sara Bergstrom Lind Mi Jia Geng Tian Stefano Gastaldello | 2019 | Journal of Molecular Cell Biology2019，11，5： | 4 |
| 2 | Familial insensitivity of the pituitary and periphery to thyroid hormone: a case report in two generations and a review of the literature 显示文摘 | Linde R Alexander N Island D | 1982 | Metabolism1982，31，5： | 1 |
| 3 | Familial insensitivity of the pituitary and periphery to thyroid hormone a case report in two generations and a review of the literature显示文摘 | Linde R Alexander N Island D P | 1982 | Metabolism1982，31，5： | 1 |
| 4 | The Softening Bureaucracy:Accommodating New ResearchOpportunities in the Entrepreneurial University显示文摘 | Alexander Styhre Frida Lind | 2010 | Scandinavian Journal of Management2010，26，2： | 1 |
| 5 | Familial insensitivity of the pituitary and periphery to thyroid hormone:a case report in two generations and a review of the literature显示文摘 | Linde R Alexander N Island D P | 1982 | Metabolism1982，31，5： | 1 |
| 6 | Cardiac resynchronisation therapy optimisation strategies: Systematic classification, detailed analysis, minimum standards and a roadmap for development and testing显示文摘 | S.M. Afzal Sohaib Zachary I. Whinnett Kenneth A. Ellenbogen Christoph Stellbrink T. Alexander Quinn Margot D. Bogaard Pierre Bordachar Berry M. van Gelder Irene E. van Geldorp Cecilia Linde Mathias Meine Frits W. Prinzen Robert G. Turcott Henry M. Spotnit | 2013 | International Journal of Cardiology2013，，2： | 1 |
| 7 | The Softening Bureaucracy:Ac-commodating New Research Opportunities in the Entrepreneurial University显示文摘 | Alexander Styhre Frida Lind | 2010 | Scandinavian Journal of Management2010，26，2： | 1 |
| 8 | Broadband 1-GHz mid-infrared frequency comb显示文摘Mid-infrared(MIR)spectrometers are invaluable tools for molecular fingerprinting and hyper-spectral imaging.Among the available spectroscopic approaches,GHz MIR dual-comb absorption spectrometers have the potential to simultaneously combine the high-speed,high spectral resolution,and broad optical bandwidth needed to accurately study complex,transient events in chemistry,combustion,and microscopy.However,such a spectrometer has not yet been demonstrated due to the lack of GHz MIR frequency combs with broad and full spectral coverage.Here,we introduce the first broadband MIR frequency comb laser platform at 1 GHz repetition rate that achieves spectral coverage from 3 to 13 μm.This frequency comb is based on a commercially available 1.56 μm mode-locked laser,robust all-fiber Er amplifiers and intra-pulse difference frequency generation(IP-DFG)of few-cycle pulses in x(2)nonlinear crystals.When used in a dual comb spectroscopy(DCS)configuration,this source will simultaneously enable measurements with μs time resolution,1 GHz(0.03 cm-1)spectral point spacing and a full bandwidth of>5 THz(>166 cm-1)anywhere within the MIR atmospheric windows.This represents a unique spectroscopic resource for characterizing fast and non-repetitive events that are currently inaccessible with other sources. | Nazanin Hoghooghi Sida Xing Peter Chang Daniel Lesko Alexander Lind Greg Rieker Scott Diddams | 2022 | Light(Science & Applications)2022，11，10： | 0 |
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