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| 1 | Caffeic acid phenethyl ester protects against oxidative stress and dampens inflammation via heme oxygenase 1显示文摘Periodontal disease is associated with chronic oxidative stress and inflammation. Caffeic acid phenethyl ester(CAPE), which is a potent inducer of heme oxygenase 1(HO1), is a central active component of propolis, and the application of propolis improves periodontal status in diabetic patients. Here, primary murine macrophages were exposed to CAPE. Target gene expression was assessed by whole-genome microarray, RT-PCR and Western blotting. The antioxidative and anti-inflammatory activities of CAPE were examined by exposure of the cells to hydrogen peroxide, saliva and periodontal pathogens. The involvement of HO1 was investigated with the HO1 inhibitor tin protoporphyrin(SnPP) and knockout mice for Nrf2, which is a transcription factor for detoxifying enzymes. CAPE increased HO1 and other heat shock proteins in murine macrophages. A p38 MAPK inhibitor and Nrf2 knockout attenuated CAPE-induced HO1 expression in macrophages. CAPE exerted strong antioxidative activity. Additionally, CAPE reduced the inflammatory response to saliva and periodontal pathogens. Blocking HO1 decreased the antioxidative activity and attenuated the anti-inflammatory activity of CAPE. In conclusion, CAPE exerted its antioxidative effects through the Nrf2-mediated HO1 pathway and its anti-inflammatory effects through NF-κB inhibition. However, preclinical models evaluating the use of CAPE in periodontal inflammation are necessary in future studies. | Alexandra St?hli Ceeneena Ubaidha Maheen Franz Josef Strauss Sigrun Eick Anton Sculean Reinhard Gruber | 2019 | International Journal of Oral Science2019，11，1： | 4 |
| 2 | 全球食品和饲料链中生物毒素早期预警、监测和毒性评估的挑战和解决方案显示文摘确保世界人口不断增长下的食品供应安全和保障是巨大和紧迫的需求。然而,全球农业和食品行业仍易受植物、藻类,尤其是真菌产生的生物毒素污染问题的挑战;随着全球变暖和极端天气事件频发,这些有毒代谢产物的发生愈发难以预测。为了提升食品和饲料链中生物毒素的预警、监测和毒性评估方法,总结在各个科学领域和方法中创新所需的多学科、多部门互补能力,具体包括使用卫星和无人机成像的大数据方法、便携式监测设备以及使用蛋白质组学和转录组学对(新兴)生物毒素进行(联合)毒性测试。 | Rudolf Krska Eskola Mari Berthiller Franz Nielen Michel Oswald Isabelle Elliott Chris McNerney Oonagh BotanaLuis Miguel MalachováAlexandra | 2021 | 粮油食品科技2021，29，6： | 2 |
| 3 | Survey of deoxynivalenol and its conjugates deoxynivalenol-3-glucoside and 3-acetyl-deoxynivalenol in 374 beer samples显示文摘 | Elisabeth Varga Alexandra Malachova Heidi Schwartz Rudolf Krska Franz Berthiller | 2013 | Food Additives & Contaminants: Part A2013，，1： | 1 |
| 4 | Ultrafiltration for environmental safety in shellfish production: A case of bloom emergence显示文摘The process of ultrafiltration(UF)of natural seawater often encounters the problems of variation in water quality and coastal blooms.To validate the feasibility of UF in shellfish farms,this study compared the hydraulic performance and pollutant removal efficiency of the UF process with those of the commonly used treatments that combine several filtration steps with ultraviolet(UV)disinfection.The comparison was conducted in the cases of natural seawater and a coastal bloom.Given that the UF process encountered the specific type of pollution,this study evaluated the filtration performance of the UF process and the retention of total suspended solids(TSS),bacteria,phytoplankton,and zooplankton.A real coastal bloom was considered in the case study of an experimental shellfish hatchery/nursery in France.The results show that both treatments were able to eliminate approximately 50%of TSS.However,in contrast with UV treatment combined with filtration,the UF process retained total amounts of phytoplankton,zooplankton,and bacteria in the bloom.Although the hydraulic performance of the UF process was impacted by the coastal bloom,the fouling was eliminated through chemical cleaning conducted at a frequency less than once per 12 h.Despite the severe pollution,this study confirmed the pollution resistance and treatment performance of the UF process,indicating that UF has the potential to enhance the biosecurity level. | Clemence Cordier Alexandra Voulgaris Christophe Stavrakakis Patrick Sauvade Franz Coelho Philippe Moulin | 2021 | Water Science and Engineering2021，14，1： | 1 |
| 5 | Thermodynamic potential and phase diagram for multiferroic bismuth ferrite(BiFeO_(3))显示文摘We construct a Landau-Ginzburg thermodynamic potential,and the corresponding phase diagram for pristine and slightly doped bismuth ferrite,a ferroelectric antiferromagnet at room temperature.The potential is developed based on new X-ray and neutron diffraction experiments complementing available data.We demonstrate that a strong biquadratic antiferrodistortive-type coupling is the key to a quantitative description of Bi_(1−x)La_(x)FeO_(3) multiferroic phase diagram including the temperature stability of the antiferromagnetic,ferroelectric,and antiferrodistortive phases,as well as for the prediction of novel intermediate structural phases.Furthermore,we show that“rotomagnetic”antiferrodistortive-antiferromagnetic coupling is very important to describe the ferroelectric polarization and antiferrodistortive tilt behavior in the R3c phase of BiFeO_(3).The Landau-Ginzburg thermodynamic potential is able to describe the sequence of serial and trigger-type phase transitions,the temperature-dependent behavior of the order parameters,and the corresponding susceptibilities to external stimuli.It can also be employed to predict the corresponding ferroelectric and antiferrodistortive properties of Bi_(1−x)La_(x)FeO_(3) thin films and nanoparticles by incorporating the gradient and surface energy terms that are strongly dependent on the shape,size,and preparation method. | Dmitry V.Karpinsky Eugene A.Eliseev Fei Xue Maxim V.Silibin Alexandra Franz Maya D.Glinchuk Igor O.Troyanchuk Sergey A.Gavrilov Venkatraman Gopalan Long-Qing Chen Anna N.Morozovska | 2017 | npj Computational Materials2017，，1： | 1 |
| 6 | Survey of deoxynivalenol and its conjugates deoxynivalenol-3-glucoside and 3-acetyl-deoxynivalenol in 374 beer samples显示文摘 | Elisabeth Varga Alexandra Malachova Heidi Schwartz Rudolf Krska Franz Berthiller | 2013 | Food Additives & Contaminants: Part A2013，，1： | 1 |
| 7 | Bivalirudin in patients undergoing primary angioplasty for acute myocardial infarction (HORIZONS-AMI): 1-year results of a randomised controlled trial显示文摘 | Roxana Mehran Alexandra J Lansky Bernhard Witzenbichler Giulio Guagliumi Jan Z Peruga Bruce R Brodie Dariusz Dudek Ran Kornowski Franz Hartmann Bernard J Gersh Stuart J Pocock S Chiu Wong Eugenia Nikolsky Louise Gambone Lynn Vandertie Helen Parise George | 2009 | The Lancet2009，，9696： | 1 |
| 8 | Global Challenges and Solutions in the Early Warning,Monitoring and Toxicity Assessment of Biotoxins in the Food and Feed Chain显示文摘There is a massive and urgent need to ensure safety and security of the food supply of the world´s growing population.However,global agriculture and food industries continue to be vulnerable to problems of contamination with biotoxins produced by plants,algae and particularly by fungi;with global warming and extreme weather events making the occurrence of these toxic metabolites even more unpredictable.In this paper we summarize the multidisciplinary,multi-sectoral complementary competencies needed to innovate in various scientific fields and approaches,so strongly needed to develop improved early warning,monitoring and toxicity assessment of biotoxins in the food and feed chain.These include big data approaches using satellite and drone images,portable monitoring devices and(combined)toxicity testing of(emerging)biotoxins using proteomics and transcriptomics. | Rudolf Krska Eskola Mari Berthiller Franz Nielen Michel Oswald Isabelle Elliott Chris McNerney Oonagh BotanaLuis Miguel MalachováAlexandra | 2021 | 粮油食品科技2021，29，6： | 0 |
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