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| 1 | MicroRNA signatures in chemotherapy resistant esophageal cancer cell lines显示文摘AIM:To investigate expression of microRNA(miRNA)and potential targets in chemotherapy resistant esoph-ageal cancer cell lines.METHODS:An in-vitro model of acquired chemotherapy resistance in esophageal adeno-(EAC)and squamous cell carcinoma(ESCC)cells was used,and microRNA expression profiles for cisplatin or 5-fluorouracil(5-FU)resistant variants vs chemotherapy sensitive controls were compared using microarray and quantitative real-time polymerase chain reaction(PCR).The expression of chemotherapy-relevant genes potentially targeted by the dysregulated microRNAs in the chemotherapy resistant variants was also evaluated.RESULTS:Chemotherapy resistant sublines were found to have specific miRNA signatures,and these miRNA signatures were different for the cisplatin vs 5-FU resistant cells from the same tumor cell line,and also for EAC vs ESCC cells with resistance to the same specific chemotherapy agent.Amongst others,miR-27b-3p,miR-193b-3p,miR-192-5p,miR-378 a-3p,miR-125a-5p and miR-18a-3p were dysregulated,consistent with negative posttranscriptional control of KRAS,TYMS,ABCC3,CBL-B and ERBB2 expression via these miRNAs.CONCLUSION:The current study supports the hypothesis that microRNA expression has an impact on chemotherapy resistance in esophageal cancer. | Richard Hummel Corina Sie David I Watson Tingting Wang Alfiya Ansar Michael Z Michael Mark Van der Hoek Joerg Haier Damian J Hussey | 2014 | World Journal of Gastroenterology2014，20，40： | 8 |
| 2 | MicroRNA profile in neosquamous esophageal mucosa following ablation of Barrett's esophagus显示文摘AIM To investigate the micro RNA expression profile in esophageal neosquamous epithelium from patients who had undergone ablation of Barrett's esophagus.METHODS High throughput screening using Taq Man~ Array Human Micro RNA quantitative PCR was used to determine expression levels of 754 micro RNAs in distal esophageal mucosa(1 cm above the gastro-esophageal junction) from 16 patients who had undergone ablation of non-dysplastic Barrett's esophagus using argon plasma coagulation vs pretreatment mucosa, posttreatment proximal normal non-treated esophageal mucosa, and esophageal mucosal biopsies from 10 controls without Barrett's esophagus. Biopsies of squamous mucosa were also taken from 5 cm above the pre-ablation squamo-columnar junction. Predicted m RNA target pathway analysis was used to investigate the functional involvement of differentially expressed micro RNAs.RESULTS Forty-four micro RNAs were differentially expressed between control squamous mucosa vs post-ablation neosquamous mucosa. Nineteen micro RNAs were differentially expressed between post-ablation neosquamous and post-ablation squamous mucosa obtained from the more proximal non-treated esophageal segment. Twelve microRNAs were differentially expressed in both neosquamous vs matched proximal squamous mucosa and neosquamous vs squamous mucosa from healthy patients. Nine micro RNAs(mi R-424-5p, mi R-127-3p, mi R-98-5p, mi R-187-3p, mi R-495-3p, mi R-34c-5p, mi R-223-5p, mi R-539-5p, mi R-376a-3p, mi R-409-3p) were expressed at higher levels in post-ablation neosquamous mucosa than in matched proximal squamous and healthy squamous mucosa. These micro RNAs were also more highly expressed in Barrett's esophagus mucosa than matched proximal squamous and squamous mucosa from controls. Target prediction and pathway analysis suggests that these micro RNAs may be involved in the regulation of cell survival signalling pathways. Three micro RNAs(mi R-187-3p, mi R-135b-5p and mi R-31-5p) were expressed at higher levels in postablation neosquamous mucosa than in matched proximal squamous and healthy squamous mucosa. These mi RNAs were expressed at similar levels in preablation Barrett's esophagus mucosa, matched proximal squamous and squamous mucosa from controls. Target prediction and pathway analysis suggests that these micro RNAs may be involved in regulating the expression of proteins that contribute to barrier function.CONCLUSION Neosquamous mucosa arising after ablation of Barrett's esophagus expresses micro RNAs that may contribute to decreased barrier function and micro RNAs that may be involved in the regulation of survival signaling pathways. | Loveena Sreedharan George C Mayne David I Watson Timothy Bright Reginald V Lord Alfiya Ansar Tingting Wang Jakob Kist David StJ Astill Damian J Hussey | 2017 | World Journal of Gastroenterology2017，23，30： | 3 |
| 3 | Age-Accelerated Atherosclerosis Correlates With Failure to Upregulate Antioxidant Genes显示文摘 | Alan R. Collins Christopher J. Lyon Xuefeng Xia Joey Z. Liu Rajendra K. Tangirala Fen Yin Rima Boyadjian Alfiya Bikineyeva Domenico Praticò David G. Harrison Willa A. Hsueh | 2009 | Circulation Research2009，，6： | 1 |
| 4 | Anti-inflammatory activity of Chios mastic gum associated with inhibition of TNF-alpha induce doxidative stress 显示文摘 | Angelike Triantafyllou Alfiya Bikineyeval Anna Dikalova | 2011 | Nutrition Journal2011，64，10： | 1 |
| 5 | One Dimensional Conv-BiLSTM Network with Attention Mechanism for IoT Intrusion Detection显示文摘In the face of escalating intricacy and heterogeneity within Internet of Things(IoT)network landscapes,the imperative for adept intrusion detection techniques has never been more pressing.This paper delineates a pioneering deep learning-based intrusion detection model:the One Dimensional Convolutional Neural Networks(1D-CNN)and Bidirectional Long Short-Term Memory(BiLSTM)Network(Conv-BiLSTM)augmented with an Attention Mechanism.The primary objective of this research is to engineer a sophisticated model proficient in discerning the nuanced patterns and temporal dependencies quintessential to IoT network traffic data,thereby facilitating the precise categorization of a myriad of intrusion types.Methodology:The proposed model amal-gamates the potent attributes of 1D convolutional neural networks,bidirectional long short-term memory layers,and attention mechanisms to bolster the efficacy and resilience of IoT intrusion detection systems.A rigorous assessment was executed employing an expansive dataset that mirrors the convolutions and multifariousness characteristic of genuine IoT network settings,encompassing various network traffic paradigms and intrusion archetypes.Findings:The empirical evidence underscores the paramountcy of the One Dimensional Conv-BiLSTM Network with Attention Mechanism,which exhibits a marked superiority over conventional machine learning modalities.Notably,the model registers an exemplary AUC-ROC metric of 0.995,underscoring its precision in typifying a spectrum of intrusions within IoT infrastructures.Conclusion:The presented One Dimensional Conv-BiLSTM Network armed with an Attention Mechanism stands out as a robust and trustworthy vanguard against IoT network breaches.Its prowess in discerning intricate traffic patterns and inherent temporal dependencies transcends that of traditional machine learning frameworks.The commendable diagnostic accuracy manifested in this study advocates for its tangible deployment.This investigation indubitably advances the cybersecurity domain,amplifying the fortification and robustness of IoT frameworks and heralding a new era of bolstered security across pivotal sectors such as residential,medical,and transit systems. | Bauyrzhan Omarov Zhuldyz Sailaukyzy Alfiya Bigaliyeva Adilzhan Kereyev Lyazat Naizabayeva Aigul Dautbayeva | 2023 | Computers, Materials & Continua2023，77，12： | 0 |
| 6 | Using a needle for sacrospinous ligament fixation for pelvic organ prolapse based on the Miyazaki technique显示文摘Background:Approximately 7%of all women will require surgery to correct pelvic organ prolapse during their lives.Of these,approximately 10%-13%will require another operation within 5 years due to recurrence of the disease.Increases in life expectancy and elderly individuals with estrogen deficiencies will mean higher rates of pelvic organ prolapse,significantly reducing the quality of life for millions of people.This study introduces technologies that can help treat pelvic prolapse while reducing the rate of recurrence.Methods:This paper outlines how to properly perform sacrospinous ligament fixation using the Miyazaki technique.Results:A needle was used to successfully perform a sacrospinous ligament fixation using Miyazaki's technique.Conclusions:Considering the Food and Drug Administration’s 2019 decision to permit surgeries with native tissue,this method can be used with sacrospinous ligament fixation as the primary treatment option for pelvic organ prolapse. | Ilnur Irekovich Musin Alfiya Galimovna Yashchuk Valentin Nikolaevich Pavlov Jianliu Wang Xiuli Sun Raisa Arkadevna Naftulovich Elena Mikhailovna Popova | 2022 | Gynecology and Obstetrics Clinical Medicine2022，2，2： | 0 |
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