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| 1 | Tumor necrosis factor-α and interleukin-6 in cirrhotic patients with spontaneous bacterial peritonitis显示文摘AIM:To evaluate the role of tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) in cirrhotic patients who have hepatic and renal impairment with spontaneous bacterial peritonitis(SBP).METHODS:We prospectively studied 120 cirrhotic patients with SBP and 80 cirrhotic patients with sterile ascitic fluid.They included 144 males and 56 females with ages ranging between 34 and 62 years.The diagnosis of cirrhosis was established by clinical and laboratory criteria that did not require histological confirmation.The severity of underlying liver disease was evaluated using Pugh's modification of Child's criteria(Child-Pugh scores).Ascitic fluid was sent to the laboratory for cell count,culture,sensitivity testing,and measurement of chemical elements(i.e.,albumin,glucose).Specimens were inoculated into aerobic and anaerobic blood culture bottles.Serum and ascitic fluid were also collected in sterile tubes at study entry(before the initiation of antibiotic treatment) and 48 h later.Assays for TNF-α and IL-6 in the serum and ascitic fluid were performed with an immunoenzymometric assay using manufacture's instructions.RESULTS:Cytokine levels in serum and ascitic fluid were significantly higher in the patients with SBP.(plasma TNF-α:135.35 ng/mL ± 11.21 ng/mL vs 92.86 ng/mL ± 17.56 ng/mL,P < 0.001;plasma IL-6:32.30 pg/mL ± 7.07 pg/mL vs 12.11 pg/mL ± 6.53 pg/mL,P < 0.001;ascitic fluid TNF-α:647.54 ± 107.11 ng/mL vs 238.43 ng/mL ± 65.42 ng/mL,P < 0.001);ascitic fluid IL-6:132.84 ng/mL ± 34.13 vs 40.41 ± 12.85 pg/mL,P < 0.001).About 48(40%) cirrhotic patients with SBP developed renal and hepatic impairment and showed significantly higher plasma and ascitic fluid cytokine levels at diagnosis of infection.[(plasma TNF-α:176.58 ± 17.84 vs 135.35 ± 11.21 ng/mL)(P < 0.001) and(IL-6:57.83 ± 7.85 vs 32.30 ± 7.07 pg/mL)(P < 0.001);ascitic fluid TNF-α:958.39 ± 135.72 vs 647.54 ± 107.11 ng/mL,(P < 0.001),ascitic fluid IL-6:654.74 ± 97.43 vs 132.84 ± 34.13 pg/mL,(P < 0.001)].Twenty nine patients(60.4%) with SBP and renal impairment died whereas,only four patients(5.55%) with SBP but without renal impairment died from gastrointestinal hemorrhage(P < 0.0005).CONCLUSION:It appears that TNF-α production may enhance liver cell injury and lead to renal impairment.This correlated well with the poor prognosis and significantly increased mortality associated with SBP in cirrhotic patients. | Muhammed AM Suliman Fawzy MH Khalil Salam SA Alkindi Anil V Pathare Ali AA Almadhani Neveen AAI Soliman | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，5： | 39 |
| 2 | Rapid isolation and identification of Mycobacterium tuberculosis from pulmonary tuberculosis patients显示文摘Objective:The Study aimed to develop a rapid inexpensive and simple method for preliminary isolation and detection of M.tuberculosis from clinical specimens.Also to probe the impact of deteriorating health measures on the pulmonary tuberculosis control program in Basra city.Methods:A simple monophasic-diphasic setup (MDCS) was used for the isolation and preliminary identification of M.tuberculosis.This setup consists of a slanted Lowenstein-Jensen medium,the bottom of it is covered with 1 mL of tuberculosis broth thus establishing a diphasic solid liquid environment at the bottom of the screw capped test tube and above them a monophasic one.Results:During 7 months period from the beginning of December 2003 to the end of June 2004,1 295 cases were managed in Tuberculosis and Chest Diseases Clinic in Basra city.Only 348 cases were diagnosed as active pulmonary tuberculosis.They consist of 232 new cases and 116 previously registered ones.The MDCS method showed higher recovery of isolation rate of M.tuberculosis(92.3%) than Lowenstein-Jensen,and pyruvate methods with 78.1%and 51.9%respectively.Also this method revealed more rapid appearance of results of 12 days than Lowenstein-Jensen,and pyruvate media with 22 days and 23 days respectively by the traditional culturing methods.Concurrently the study revealed that drug resistance against one or more anti tuberculosis drugs was 23.1%for new cases and 70.8%for the old ones.Multi drug resistance accounts for 20%of total isolates from old cases.This was based on using the critical concentration and 1%proportional procedures.Tuberculosis was more common among males than females with 69.4%and 30.6%respectively. A significant correlation(P<0.05) was found between the productive age group(25-54) and incidence of tuberculosis. Tuberculosis was higher among married(83.8%) than unmarried peoples(22%).Children,husbands and wives showed higher infection rates than others indicating kinship influence.Failure of treatment was highly affected by improper use of anti tuberculosis drugs.Conclusion:The MDCS method exhibited several advantages over other culturing techniques exemplified by elimination of transport medium,establishment of simultaneous but two separate environments to accomplish both the detection and preliminary identification of M.tuberculosis,providing flexibility in the kinds of media used in the liquid and solid phases and it is inexpensive. | Al-Sulami AA Ali ZM Al-Maleky DA | 2009 | Asian Pacific Journal of Tropical Medicine2009，2，3： | 3 |
| 3 | β blocker effects on postoperative atrial fibrillation显示文摘 | Ali IM Sanalla AA Clark V | 1997 | Eur J Cardio-thoracic Surg1997，11，： | 1 |
| 4 | New aspects in probucol cardioprotection against doxorubicin-induced cardiotoxicity 显示文摘 | El-Demerdash E Ali AA Sayed-Ahmed MM | 2003 | Cancer Chemother Pharmacol2003，52，5： | 1 |
| 5 | Prospectiveobservational studies of the management and outcomes inpatients with atrial fibrillation:a systematic review 显示文摘 | Hersi AS Alsheikh -Ali AA’Zubaid M | 2012 | JSaud Heart Assoc2012，24，4： | 1 |
| 6 | Short dental implants: An emerging concept in implant treatment显示文摘 | A1-Hashedi AA Taiveb Ali TB Yunus N | 2014 | Quintessence International2014，45，6： | 1 |
| 7 | Application and assessment of a dipstick assay in the diagnosis of hydatidosis and trichinosis显示文摘 | Al-Sherbiny MM Farrag AA Fayad MH Makled MK Tawfeek GM Ali NM 2004 | 2004 | Parasitol Res2004，93，2： | 1 |
| 8 | Curvelet fusion of MR and CT images显示文摘 | Ali FE EI-Dokany IM Saad AA | 2008 | Progress In Electromagnetics Research C2008，3，： | 1 |
| 9 | New aspects in probucol cardioprotection against doxorubicin-induced cardiotoxicity显示文摘 | El-Bemerdash E Ali AA Sayed -Ahmed MM Osman AM | 2003 | Cancer Chemother Pharmacol2003，52，5： | 1 |
| 10 | Effects of adrenomedullin on cyclic AMP formation and on relaxation in iris sphincter smooth muscle显示文摘 | Yousufzai SYK Ali N Abdel-Latif AA | | 0，，： | 1 |
| 11 | Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts显示文摘 | Bellido T Ali AA Plotkin LI | 2003 | J Biol Chem2003，278，50： | 1 |
| 12 | Diagnosis of ruptured ectopic pregnancy is still a challenge in eastern Sudan 显示文摘 | Ali AA Abdallah TM Siddig MF | 2011 | Afr J Repred Health2011，15，4： | 1 |
| 13 | Development and validation of a stoma-quality of life scale in Arabic for Egyptian patients with perma- nent colostomy显示文摘 | Ali WGM Hassanin AA Elatif ZA | 2010 | J Med and Biomedical Sci2010，1，2： | 1 |
| 14 | Intermittent PTHstimulates periosteal bone formation by actions on post-mitotic preosteoblasts显示文摘 | Jilka RL O'Brien CA Ali AA | 2009 | Bone2009，44，2： | 1 |
| 15 | Patent foramen ovale in eryptogenic stroke : incidental or pathogenic? 显示文摘 | Alsheikh Ali AA Thaler DE Kent DM | 2009 | Stroke2009，40，7： | 1 |
| 16 | Prevention of sevoflurane related emergence agitation in children undergoing adenotonsillectomy: A comparison of dexmedetomidine and propofo| 显示文摘 | Ali MA Abdellatif AA | 2013 | Saudi J Anaesth2013，7，3： | 1 |
| 17 | Cutaneous sarcoidosis: updates in the pathogenesis 显示文摘 | Ali MM Atwan AA Gonzalez ML | 2010 | J Eur Acad Dermatol Venereol2010，24，3： | 1 |
| 18 | Predictive value of neutrophil to lymphocyte ratio in outcomes of patients with acute coronary syndrome 显示文摘 | Muhmmed Suliman MA Bahnacy Juma AA Ali Almadhani AA | 2010 | Arch Med Res2010，41，8： | 1 |
| 19 | Co-oximetry interference by hemoglobin-based blood substitutes显示文摘 | Ali AA Ali GS Steinke JM | 2001 | Anesth Analg2001，92，4： | 1 |
| 20 | Rosiglitazone causes bone loss in mice by suppressing osteoblast differentiation and bone formation显示文摘 | Ali AA Weinstein RS Stewart SA | 2005 | Endocrinology2005，146，3： | 1 |
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