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| 1 | Hepatitis B virus subgenotypes and basal core promoter mutations in Indonesia显示文摘AIM:To identify the distribution of hepatitis B virus (HBV) subgenotype and basal core promoter (BCP) mutations among patients with HBV-associated liver disease in Indonesia.METHODS: Patients with chronic hepatitis (CH, n=61), liver cirrhosis (LC, n=62), and hepatocellular carcinoma (HCC,n=48) were included in this study. HBV subgenotype was identified based on S or preS gene sequence, and mutations in the HBx gene including the overlapping BCP region were examined by direct sequencing.RESULTS: HBV genotype B (subgenotypes B2, B3, B4, B5 and B7) the major genotype in the samples, accounted for 75.4%, 71.0% and 75.0% of CH, LC and HCC patients, respectively, while the genotype C (subgenotypes C1, C2 and C3) was detected in 24.6%, 29.0%, and 25.0% of CH, LC, and HCC patients, respectively. Subgenotypes B3 (84.9%) and C1 (82.2%) were the main subgenotype in HBV genotype B and C, respectively. Serotype adw2 (84.9%) and adrq+ (89.4%) were the most prevalent in HBV genotype B and C, respectively. Double mutation (A1762T/G1764A) in the BCP was significantly higher in LC (59.7%) and HCC (54.2%) than in CH (19.7%), suggesting that this mutation was associated with severity of liver disease. The T1753V was also higher in LC (46.8%), but lower in HCC (22.9%) and CH (18.0%), suggesting that this mutation may be an indicator of cirrhosis.CONCLUSION: HBV genotype B/B3 and C/C1 are the major genotypes in Indonesia. Mutations in BCP, such as A1762T/G1764A and T1753V, might have an association with manifestations of liver disease. | Andi Utama Sigit Purwantomo Marlinang Diarta Siburian Rama Dhenni Rino Alvani Gani Irsan Hasan Andri Sanityoso Upik Anderiani Miskad Fardah Akil Irawan Yusuf Wenny Astuti Achwan Soewignjo Soemohardjo Syafruddin AR Lelosutan Ruswhandi Martamala Benyamin Lukito Unggul Budihusodo Laurentius Adrianus Lesmana Ali Sulaiman Susan Tai | 2009 | World Journal of Gastroenterology2009，15，32： | 4 |
| 2 | Hepatitis B virus pre-S2 start codon mutations in Indonesian liver disease patients显示文摘AIM: To identify the prevalence of pre-S2 start codon mutations and to assess their association with liver disease progression. METHODS: The mutations were identified by direct sequencing from 73 asymptomatic carriers, 66 chronic hepatitis (CH), 66 liver cirrhosis (LC) and 63 hepatocellular carcinoma (HCC) patients. Statistical significances were determined using Fisher's exact test, χ 2 test, and t -test analyses whenever appropriate. Pre-S mutation as a risk factor for advanced liver disease was estimated by unconditional logistic regression model adjusted with age, sex, and hepatitis B e antigen (HBeAg). P < 0.05 was considered significant. RESULTS: Mutation of the hepatitis B virus (HBV) pre-S2 start codon was found in 59 samples from 268 subjects (22.0%), with higher prevalence in patients with cirrhosis 27/66 (40.9%) followed by HCC 18/63 (28.6%), chronic hepatitis 12/66 (18.2%) and asymptomatic carriers 2/73 (2.7%) (P < 0.001). Logistic regression analysis showed that pre-S2 start codon mutation was an independent factor for progressive liver disease. Other mutations, at T130, Q132, and A138, were also associated with LC and HCC, although this was not statistically significant when adjusted for age, sex, and HBeAg. The prevalence of pre-S2 start codon mutation was higher in HBV/B than in HBV/C (23.0% vs 19.1%), whilst the prevalence of T130, Q132, and A138 mutation was higher in HBV/C than in HBV/B. The prevalence of pre-S2 start codon mutation was higher in LC (38.9%) and HCC (40.0%) than CH (5.6%) in HBeAg(+) group, but it was similar between CH, LC and HCC in HBeAg(-) group. CONCLUSION: Pre-S2 start codon mutation was higher in Indonesian patients compared to other Asian countries, and its prevalence was associated with advanced liver disease, particularly in HBeAg(+) patients. | Andi Utama Marlinang Diarta Siburian Ismail Fanany Mariana Destila Bayu Intan Rama Dhenni Tri Shinta Kurniasih Syafruddin AR Lelosutan Wenny Astuti Achwan Nasrul Zubir Arnelis Benyamin Lukito Irawan Yusuf Laurentius Adrianus Lesmana Ali Sulaiman | 2012 | World Journal of Gastroenterology2012，18，38： | 3 |
| 3 | High-intensity versus low- level laser therapy in the treatment of patients with knee oste- oarthritis: a randomized controlled trial 显示文摘 | Kheshie AR Alayat MS Ali MM | 2014 | Lasers Med Sci2014，29，4： | 1 |
| 4 | The effects of combining docetaxeland cyclooxygenase - 2 inhibitors on proliferation and apoptosis in epithelial ovarian cancer显示文摘 | Munkarah AR Ali - Fehmi R Jiang JZ | 2007 | Anticancer Drugs2007，18，： | 1 |
| 5 | Myocardial tissue engineering: a review显示文摘 | Jawad H Ali NN Lyon AR | 2007 | J Tissue Eng Regen Med2007，1，32： | 1 |
| 6 | Synthesis and bio- logical evaluation of gemcitabine-lipid conjugate (NEO- 6002 ) 显示文摘 | Ali SM Khan AR Ahmad MU | 2007 | Bioorg Med Chem Lett2007，15，10： | 1 |
| 7 | Role of human metapneumovirus,influenza A virus and respiratory syncytial virus in causing WHO-defined severe pneumonia in children in a developing country显示文摘 | Ali A Khowaja AR Bashir M2 | 2013 | PLoS One2013，8，74： | 1 |
| 8 | Statin-mediated cytoprotection of human vascular endothelial cells:a role for Kruppel-like factor 2-dependent induction of heine oxygenase-1显示文摘 | Ali F Hamdulay SS Kinderlerer AR | 2007 | J Thromb Haemost2007，5，12： | 1 |
| 9 | Statin-mediated cytoprotection of human vascular endothelial ceils:a role for Kruppel-like factor 2-dependent induction of heme oxygenase-I显示文摘 | Hamdulay SS Kinderlerer AR | 2007 | J Thromb Haemost2007，5，12： | 1 |
| 10 | Efficacy and safety of aripiprazole and risperidone vs placebo in patients with schizophrenia and schizoaffective disorder显示文摘 | Saha AR Carson WH Ali MW | 2001 | WJ boil psychiat2001，2，1： | 1 |
| 11 | Statin-mediated cytoprotection of human vascular endothelial cells:a role for Kruppel-like factor 2-dependent induction of heme oxygenase-1显示文摘 | Ali F Hamdulay SS Kindederer AR | 2007 | J Thromb Haemost2007，5，12： | 1 |
| 12 | Lateral flagella of Aeromonas species are essential for epithelial cell adherence and biofilm formarion显示文摘 | Rosalina G Ali AR Susana M | 2002 | Mol Microbiol2002，43，2： | 1 |
| 13 | Microvessel density as a prognostic marker in bladder carcinoma: Correlation with tumor grade, stage and prognosis显示文摘 | Ali Cano?lu ?a?atay G??ü? Ya?ar Bedük Diclehan Orhan ?zden Tulunay Sümer Baltac? | 2004 | International Urology and Nephrology2004，，3： | 1 |
| 14 | Neuroprotection and stroke:time for a compromise显示文摘 | Young AR Ali C Duretete A | 2007 | J Neurochem2007，103，4： | 1 |
| 15 | Neuroprotection and stroke:Time for a compromise显示文摘 | Young AR Ali C Duretête A | | 0，，04： | 1 |
| 16 | Effcacy and safety of aripiprazole end fiperdone vs placebs inpatients with shizophreniaend schizoaffective desorde显示文摘 | SAHA AR CARSON WH ALI MW er al | 2001 | WJ Biolpsycheat2001，，： | 1 |
| 17 | Topical steroid use in the treatment of oular alkali bums 显示文摘 | Davis AR Ali QK Aclimandos WA | 1997 | Br J Oph- thalmol1997，81，： | 1 |
| 18 | Statin-mediated cytoprotection of human vascular endothelial cells:a role forKruppel-like factor2-dependent induction of heme oxygenase-1显示文摘 | Ali F Hamdulay SS Kinderlerer AR | 2007 | J Thromb Haemost2007，5，12： | 1 |
| 19 | Quantitative estimation of Nipah virus replication kinetics in vitro显示文摘 | Chang LY Ali AR Hassan SS | 2006 | Virol J2006，3，： | 1 |
| 20 | Dexmedetomidine versus fentanyl as adjluvant to propofol:comparative study in children undergoing extracortx,real shock wave lithotripsy显示文摘 | Ali AR El Ghoneimy MN | 2010 | Eur J Anaesthesiol2010，27，12： | 1 |
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