| 1 | Clinical presentation,management,screening and surveillance for colorectal cancer during the COVID-19 pandemic显示文摘Management of colorectal cancer(CRC)was severely affected by the changes implemented during the pandemic,and this resulted in delayed elective presentation,increased emergency presentation,reduced screening and delayed definitive therapy.This review was conducted to analyze the impact of the coronavirus disease 2019(COVID-19)pandemic on management of CRC and to identify the changes made in order to adapt to the pandemic.We performed a literature search in PubMed,Medline,Index Medicus,EMBASE,SCOPUS,Reference Citation Analysis(https://www.referencecitationanalysis.com/)and Google Scholar using the following keywords in various combinations:Colorectal cancer,elective surgery,emergency surgery,stage upgrading,screening,surveillance and the COVID-19 pandemic.Only studies published in English were included.To curtail the spread of COVID-19 infection,there were modifications made in the management of CRC.Screening was limited to high risk individuals,and the screening tests of choice during the pandemic were fecal occult blood test,fecal immunochemical test and stool DNA testing.The use of capsule colonoscopy and open access colonoscopy was also encouraged.Blood-based tests like serum methylated septin 9 were also encouraged for screening of CRC during the pandemic.The presentation of CRC was also affected by the pandemic with more patients presenting with emergencies like obstruction and perforation.Stage migration was also observed during the pandemic with more patients presenting with more advanced tumors.The operative therapy of CRC was altered by the pandemic as more emergencies surgeries were done,which may require exteriorization by stoma.This was to reduce the morbidity associated with anastomosis and encourage early discharge from the hospital.There was also an initial reduction in laparoscopic surgical procedures due to the fear of aerosols and COVID-19 infection.As we gradually come out of the pandemic,we should remember the lessons learned and continue to apply them even after the pandemic passes. | Sami Akbulut Abdirahman Sakulen Hargura Ibrahim Umar Garzali Ali Aloun Cemil Colak | 2022 | World Journal of Clinical Cases2022，10，26： | 1 |
| 2 | Outcome of split liver transplantation vs living donor liver transplantation:A systematic review and meta-analysis显示文摘BACKGROUND The outcomes of liver transplantation(LT)from different grafts have been studied individually and in combination,but the reports were conflicting with some researchers finding no difference in both short-term and long-term outcomes between the deceased donor split LT(DD-SLT)and living donor LT(LDLT).AIM To compare the outcomes of DD-SLT and LDLT we performed this systematic review and meta-analysis.METHODS This systematic review was performed in compliance with the Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines.The following databases were searched for articles comparing outcomes of DD-SLT and LDLT:PubMed;Google Scholar;Embase;Cochrane Central Register of Controlled Trials;the Cochrane Database of Systematic Reviews;and Reference Citation Analysis(https://www.referencecitationanalysis.com/).The search terms used were:“liver transplantation;”“liver transplant;”“split liver transplant;”“living donor liver transplant;”“partial liver transplant;”“partial liver graft;”“ex vivo splitting;”and“in vivo splitting.”RESULTS Ten studies were included for the data synthesis and meta-analysis.There were a total of 4836 patients.The overall survival rate at 1 year,3 years and 5 years was superior in patients that received LDLT compared to DD-SLT.At 1 year,the hazard ratios was 1.44(95%confidence interval:1.16-1.78;P=0.001).The graft survival rate at 3 years and 5 years was superior in the LDLT group(3 year hazard ratio:1.28;95%confidence interval:1.01-1.63;P=0.04).CONCLUSION This meta-analysis showed that LDLT has better graft survival and overall survival when compared to DD-SLT. | Ibrahim Umar Garzali Sami Akbulut Ali Aloun Motaz Naffa Fuat Aksoy | 2023 | World Journal of Gastrointestinal Surgery2023，15，7： | 0 |
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