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| 1 | Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy显示文摘BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal adenocarcinoma.Currently,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)imaging.Despite using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of IPMNs.We hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN histology.AIM To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus Guidelines.METHODS Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective cohort.Whole lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast phase.Univariate analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic regression.Conventional quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and Mann Whitney U(continuous)variables.RESULTS Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the'malignant'cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the'benign'cohort.Radiomic analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features differentiated malignant from benign IPMNs(P<0.05).Multivariate analysis including only ICG criteria yielded two significant variables:thickened and enhancing cyst wall and enhancing mural nodule<5 mm with an AUC(95%CI)of 0.817(0.709-0.926).Multivariable post contrast radiomics achieved an AUC(95%CI)of 0.87(0.767-0.974)for a model including arterial phase radiomics features and 0.834(0.716-0.953)for a model including venous phase radiomics features.Combined multivariable model including conventional variables and arterial phase radiomics features achieved an AUC(95%CI)of 0.93(0.85-1.0)with a 5-fold cross validation AUC of 0.90.CONCLUSION Multi-phase CT radiomics evaluation could play a role in improving predictive capability in diagnosing malignancy in IPMNs.Future larger studies may help determine the clinical significance of our findings. | Stuart L Polk Jung W Choi Melissa J McGettigan Trevor Rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 2 | Colonoscopy surveillance for high risk polyps does not always prevent colorectal cancer显示文摘AIM To determine the frequency and risk factors for colorectal cancer(CRC) development among individuals with resected advanced adenoma(AA)/traditional serrated adenoma(TSA)/advanced sessile serrated adenoma(ASSA). METHODS Data was collected from medical records of 14663 subjects found to have AA, TSA, or ASSA at screening or surveillance colonoscopy. Patients with inflammatory bowel disease or known genetic predisposition for CRC were excluded from the study. Factors associated with CRC developing after endoscopic management of high risk polyps were calculated in 4610 such patients who had at least one surveillance colonoscopy within 10 years following the original polypectomy of the incident advanced polyp. RESULTS84/4610(1.8%) patients developed CRC at the polypectomy site within a median of 4.2 years(mean 4.89 years), and 1.2%(54/4610) developed CRC in a region distinct from the AA/TSA/ASSA resection site within a median of 5.1 years(mean 6.67 years). Approximately, 30%(25/84) of patients who developed CRC at the AA/TSA/ASSA site and 27.8%(15/54) of patients who developed CRC at another site had colonoscopy at recommended surveillance intervals. Increasing age; polyp size; male sex; right-sided location; high degree of dysplasia; higher number of polyps resected; and piecemeal removal were associated with an increased risk for CRC developmentat the same site as the index polyp. Increasing age; right-sided location; higher number of polyps resected and sessile endoscopic appearance of the index AA/TSA/ASSA were significantly associated with an increased risk for CRC development at a different site. CONCLUSION Recognition that CRC may develop following AA/TSA/ASSA removal is one step toward improving our practice efficiency and preventing a portion of CRC related morbidity and mortality. | Mohamad A Mouchli Lidia Ouk Marianne R Scheitel Alisha P Chaudhry Donna Felmlee-Devine Diane E Grill Shahrooz Rashtak Panwen Wang Junwen Wang Rajeev Chaudhry Thomas C Smyrk Ann L Oberg Brooke R Druliner Lisa A Boardman | 2018 | World Journal of Gastroenterology2018，24，8： | 5 |
| 3 | Management of pregnancy in Crigler Najjar syndrome type 2显示文摘Crigler Najjar syndrome is associated with indirect hyperbilirubinemia due to a deficiency of enzyme Uridine Di Phospho Glucoronosyl Transferase(UDPGT).Presented here is a case of a female in the first trimester of pregnancy,who was diagnosed to have type 2 Crigler Najjar syndrome.We also discuss the management of this rare disease especially in pregnancy.Unconjugated bilirubin can cross the placental barrier causing neuro-logical damage in the newborn.Patient was carefully monitored during pregnancy and treatment with pheno-barbitone in low doses was adjusted such that the serum bilirubin levels were below 10 mg/d L.Crigler Najjar syndrome being rare needs to be diagnosed early in pregnancy to avoid adverse fetal outcomes.Phenobarbitone being an inducer of enzyme UDPGT is used as the first line of treatment and is not teratogenic in the low doses used.Treatment protocol followed was on the basis of previous reported cases and successful perinatal outcome was achieved. | Alisha Nitin Chaubal Ruchir Patel Dhaval Choksi Kaivan Shah Meghraj Ingle Prabha Sawant | 2016 | World Journal of Hepatology2016，8，11： | 4 |
| 4 | Osteoclasts are not a source of SLIT3显示文摘The axon guidance cue SLIT3 was identified as an osteoanabolic agent in two recent reports. However, these reports conflict in their nomination of osteoblasts versus osteoclasts as the key producers of skeletal SLIT3 and additionally offer conflicting data on the effects of SLIT3 on osteoclastogenesis. Here, aiming to address this discrepancy, we found no observable SLIT3 expression during human or mouse osteoclastogenesis and the only modest SLIT3-mediated effects on osteoclast differentiation. Conditional deletion of SLIT3 in cathepsin K(CTSK)-positive cells, including osteoclasts, had no effect on the number of osteoclast progenitors, in vitro osteoclast differentiation, overall bone mass, or bone resorption/formation parameters. Similar results were observed with the deletion of SLIT3 in Lys M-positive cells, including osteoclast lineage cells. Consistent with this finding, bone marrow chimeras made from Slit3-/-donors that lacked SLIT3 expression at all stages of osteoclast development displayed normal bone mass relative to controls. Taken in context, multiple lines of evidence were unable to identify the physiologic function of osteoclast-derived SLIT3,indicating that osteoblasts are the major source of skeletal SLIT3. | Na Li Kazuki Inoue Jun Sun Yingzhen Niu Sarfaraz Lalani Alisha Yallowitz Xu Yang Chao Zhang Rong Shen Baohong Zhao Ren Xu Matthew B.Greenblatt | 2020 | Bone Research2020，8，2： | 4 |
| 5 | Challenges and perspectives for structural biology of IncRNAs-the example of the Xist IncRNA A-repeats显示文摘Following the discovery of numerous long non-coding RNA(IncRNA)transcripts in the human genome,their important roles in biology and human disease are emerging.Recent progress in experimental methods has enabled the identification of structural features of IncRNAs.However,determining high-resolution structures is challenging as IncRNAs are expected to be dynamic and adopt multiple conformations,which may be modulated by interaction with protein binding partners.The X-inactive specific transcript(Xist)is necessary for X inactivation during dosage compensation in female placental mammals and one of the beststudied IncRNAs.Recent progress has provided new insights into the domain organization,molecular features,and RNA binding proteins that interact with distinct regions of Xist.The A-repeats located at the 5'end of the transcript are of particular interest as they are essential for mediating silencing ofthe inactive X chromosome.Here,we discuss recent progress with elucidating structural features of the Xist IncRNA,focusing on the A-repeats.We discuss the experimental and computational approaches employed that have led to distinct structural models,likely reflecting the intrinsic dynamics of this RNA.The presence of multiple dynamic conformations may also play an important role in the formation ofthe associated RNPs,thus influencing the molecular mechanism underlying the biological function of the Xist A-repeats.We propose that integrative approaches that combine biochemical experiments and high-resolution structural biology in vitro with chemical probing and functional studies in vivo are required to unravel the molecular mechanisms of IncRNAs. | Alisha NJones Michael Sattler | 2019 | Journal of Molecular Cell Biology2019，11，10： | 2 |
| 6 | Changes in Growth,Photosynthetic Pigments,Cell Viability,Lipid Peroxidation and Antioxidant Defense System in Two Varieties of Chickpea(Cicer arietinum L.)Subjected to Salinity Stress显示文摘Salinity is one of the most severe abiotic stresses for crop production.The present study investigates the salinityinduced modulation in growth indicators,morphology and movement of stomata,photosynthetic pigments,activity of carbonic anhydrase as well as nitrate reductase,and antioxidant systems in two varieties of chickpea(Pusa-BG5023,and Pusa-BGD72).On 20^(th) day of sowing,plants were treated with varying levels of NaCl(0,50,100,150 and 200 mM)followed by sampling on 45 days of sowing.Recorded observations on both the varieties reveal that salt stress leads to a significant decline in growth,dry biomass,leaf area,photosynthetic pigments,protein content,stomatal behavior,cell viability,activity of nitrate reductase and carbonic anhydrase with the rise in the concentration of salt.However,quantitatively these changes were less in Pusa-BG5023 as compared to Pusa-BGD72.Furthermore,salinity-induced oxidative stress enhanced malondialdehyde content,superoxide radicals,foliar proline content,and the enzymatic activities of superoxide dismutase,catalase,and peroxidase.The variety Pusa-BGD72 was found more sensitive than Pusa-BG5023 to salt stress.Out of different graded concentrations(50,100,150 and 200 mM)of sodium chloride,50 mM was least toxic,and 200 mM was most damaging.The differential behavior of these two varieties measured in terms of stomatal behavior,cell viability,photosynthetic pigments,and antioxidant defense system can be used as prospective indicators for selection of chickpea plants for salt tolerance and sensitivity. | Zeenat Mushtaq Shahla Faizan Basit Gulzar Humira Mushtaq Sayyada Bushra Alisha Hussain Khalid Rehman Hakeem | 2022 | Phyton-International Journal of Experimental Botany2022，91，1： | 1 |
| 7 | Prophylactic tracheal intubation for upper GI bleeding: A meta-analysis显示文摘AIM: To evaluate usefulness of prophylactically intubating upper gastrointestinal bleeding(UGIB) patients. METHODS: UGIB results in a significant number of hospital admissions annually with endoscopy being the key intervention. In these patients, risks are associated with the bleeding and the procedure, including pulmonary aspiration. However, very little literature is available assessing the use of prophylactic endotracheal intubation on aspiration in these patients. A comprehensive search was performed in May 2014 in Scopus, CINAHL, Cochrane databases, Pub Med/Medline, Embase, and published abstracts from national gastroenterology meetings in the United States(2004-2014). Included studies examined UGIB patients and compared prophylactic intubation to no intubation before endoscopy. Meta-analysis was conducted using Rev Man 5.2 by Mantel-Haenszel and Der Simonian and Laird models with results presented as odds ratio for aspiration, pneumonia(within 48 h), and mortality. Funnel plots were utilized for publication bias and I2 measure of inconsistency for heterogeneity assessments. RESULTS: Initial search identified 571 articles. Of these articles, 10 relevant peer-reviewed articles in English and two relevant abstracts were selected to review by two independent authors(Almashhrawi AA and Bechtold ML). Of these studies, eight were excluded: Five did not have a control arm, one was a letter the editor, one was a survey study, and one was focused on prevention of UGIB. Therefore, four studies(N = 367) were included. Of the UGIB patients prophylactically intubated before endoscopy, pneumonia(within 48 h) was identified in 20 of 134(14.9%) patients as compared to 5 of 95(5.3%) patients that were not intubated prophylactically(P = 0.02). Despite observed trends, no significantdifferences were found for mortality(P = 0.18) or aspiration(P = 0.11).CONCLUSION: Pneumonia within 48 h is more likely in UGIB patients who received prophylactic endotracheal intubation prior to endoscopy. | Ashraf A Almashhrawi Rubayat Rahman Samuel T Jersak Akwi W Asombang Alisha M Hinds Hazem T Hammad Douglas L Nguyen Matthew L Bechtold | 2015 | World Journal of Meta-Analysis2015，3，1： | 1 |
| 8 | Compression plating of mandibular angle fractures显示文摘 | Kris SM Alisha W | 2005 | Arch Otolarynogol Head Neck Surg2005，131，： | 1 |
| 9 | Effect of temperature on fiber/matrix interface sliding stress in SCS-6/Timetal?21S显示文摘 | Alisha Hutson Reji John Jay Jira | 1999 | Scripta Materialia1999，，5： | 1 |
| 10 | Rhythm and blues: Animal models of epilepsy and depression comorbidity显示文摘 | S. Alisha Epps David Weinshenker | 2012 | Biochemical Pharmacology2012，，： | 1 |
| 11 | In Situ, Multidisciplinary, Simulation-Based Teamwork Training Improves Early Trauma Care显示文摘 | Susan Steinemann Benjamin Berg Alisha Skinner Alexandra DiTulio Kathleen Anzelon Kara Terada Catherine Oliver Hao Chih Ho Cora Speck | 2011 | Journal of Surgical Education2011，，6： | 1 |
| 12 | Progression of fretting fatigue damage in Ti-6Al -4V显示文摘 | Alisha Hutson Shamachary Sathish Ted Nicholas | 2006 | Tribology International2006，39，10： | 1 |
| 13 | Effect of Surface Treatments on Fretting Fatigue of Ti-6Al-4V 显示文摘 | Patrick J Golden Alisha Hutson Vasan Sunda | 2007 | International Journal of Fatigue2007，29，7： | 1 |
| 14 | Vec- tor-based RNAi, a novel tool for isoform - specific knockdown of VEGF and antiangio -genesis gene therapy of cancer显示文摘 | ZHANG LIN YANG NUO ALISHA MOHAMED-HADLEYB | 2003 | Biochem Biophys Res Commun2003，303，4： | 1 |
| 15 | Exercise and the Treatmant of Clinical Depression in Adults 显示文摘 | Alisha L | 2002 | Sport Med2002，，： | 1 |
| 16 | Effect of surface treatments on fretting fatigue of Ti–6Al–4V显示文摘 | Patrick J. Golden Alisha Hutson Vasan Sundaram James H. Arps | 2006 | International Journal of Fatigue2006，，7： | 1 |
| 17 | A preliminary assessment of the relationship between project success, system engineering, team organization显示文摘 | Paul J Componation Alisha D Youngblood Dawn R Utley | 2008 | Engineering Management Journal2008，20，4： | 1 |
| 18 | Novel image cy- tometric method for detection of physiological and metabolic changes in Saccharomyces cerevisiae显示文摘 | Leo L Chan Alexandria Kury Alisha Wilkinson | 2012 | J Ind Mierobiol Biotechnoi2012，39，11： | 1 |
| 19 | Vector-based RNAi,a no- vel tool for isoform specific knockdown of VEGF and antiangio- genesis gene therapy of cancer显示文摘 | Zhang L Yang N Alisha MH | 2003 | Biochem Biophys Res Corn- mum2003，303，4： | 1 |
| 20 | Quantitative Analysis of Crime Incidents in Chicago Using Data Analytics Techniques显示文摘In this paper we aim to identify certain social factors that influence,and thus can be used to predict,the occurrence of crimes.The factors under consideration for this analytic are social demographics such as age,sex,poverty,etc.,train ridership,traffic density and the number of business licenses per community area in Chicago,IL.A factor will be considered pertinent if there is high correlation between it and the number of crimes of a particular type in that community area. | Daniel Rivera Ruiz Alisha Sawant | 2019 | Computers, Materials & Continua2019，，5： | 1 |
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