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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Gastroenterologist perceptions of faecal microbiota transplantation显示文摘AIM: To explore gastroenterologist perceptions towards and experience with faecal microbiota transplantation(FMT).METHODS: A questionnaire survey consisting of 17 questions was created to assess gastroenterologists' attitude towards and experience with FMT. This was anonymously distributed in hard copy format amongst attendees at gastroenterology meetings in Australia between October 2013 and April 2014. Basic descriptive statistical analyses were performed.RESULTS: Fifty-two clinicians participated. Twenty one percent had previously referred patients for FMT,8% more than once. Ninety percent would refer patients with Clostridium difficile infection(CDI) for FMT if easily available,37% for ulcerative colitis,13% for Crohn's disease and 6% for irritable bowel syndrome. Six percent would not refer any indication,including recurrent CDI. Eighty-six percent would enroll patients in FMT clinical trials. Thirty-seven percent considered the optimal mode of FMT administration transcolonoscopic,17% nasoduodenal,13% enema and 8% oral capsule. The greatest concerns regarding FMT were: 42% lack of evidence,12% infection risk,10% non infectious adverse effects/lack of safety data,10% aesthetic,10% lack of efficacy,4% disease exacerbation,and 2% inappropriate use; 6% had no concerns. Seventy seven percent believed there is a lack of accessibility while 52% had an interest in learning how to provide FMT. Only 6% offered FMT at their institution.CONCLUSION: Despite general enthusiasm,most gastroenterologists have limited experience with,or access to,FMT. The greatest concerns were lack of supportive evidence and safety issues. However a significant proportion would refer indications other than CDI for FMT despite insufficient evidence. These data provide guidance on where education and training are required. | Sudarshan Paramsothy Alissa J Walsh Thomas Borody Douglas Samuel Johan van den Bogaerde Rupert WL Leong Susan Connor Watson Ng Hazel M Mitchell Nadeem O Kaakoush Michael A Kamm | 2015 | World Journal of Gastroenterology2015，21，38： | 5 |
| 3 | Integrated Life Cycle Assessment and Life Cycle Cost Analysis Model for Concrete Bridge Deck Applications显示文摘 | Alissa K Gregory A Gloria E | 2005 | Journal of Infrastructure Systems2005，14，3： | 1 |
| 4 | Quantification of the re- lationship between the environment and Fusarlum head blight, Fusarium pathogen density, and mycotoxins in winter wheat in Europe 显示文摘 | Alissa B K Paul P A Xu X M etal | 2012 | Europe Plant Pathol2012，133，97： | 1 |
| 5 | Social Media, Administrative Agencies, and the First A- mendment 显示文摘 | Alissa A | 2013 | Administrative Law Review2013，65，2： | 1 |
| 6 | Integrating urbanization into landscape-level ecological assessments 显示文摘 | Jeffrey D K alissa M Ralph J A | 2001 | Ecosystems2001，4，： | 1 |
| 7 | Integrating urbanization into landscape-level ecological assessments 显示文摘 | JEFFREY D ALISSA M RALPH A | 2001 | Ecosystem2001，4，1： | 1 |
| 8 | Life cycle modeling of concrete bridge design: comparison of engineered cementitious composite link slabs and conventional steel expansion joints显示文摘 | KEOLEIAN G A KENDALL Alissa DETTLING J E | 2005 | Jour- nal of Infrastructure Systems2005，11，1： | 1 |
| 9 | Life cycle modeling of concrete bridge design显示文摘 | Gregory A Keoleian Alissa Kendall | 2005 | Journal of Infrastructure System2005，，11： | 1 |
| 10 | Integrating urbanization into landscape level ecological assessments显示文摘 | Jeffrey D K Alissa M Ralph J A | 2001 | Ecosystems2001，4，1： | 1 |
| 11 | Trophic relations in a streamfood web:importance of fatty acids for macroinvertebrate consum-ers显示文摘 | MONICA T R JOHN D W ALISSA A P | 2007 | Journal of the American Benthological Society2007，26，3： | 1 |
| 12 | Integrating urbanization into landscape-level ecological assessments显示文摘 | Jefery D K Alissa M Ralph J A | 2001 | Ecosystem2001，，4： | 1 |
| 13 | Integrating Urbanization into Landscape -level Ecological Assessments显示文摘 | Jeffrey D K Alissa M Ralph J A | 2001 | Ecosystems2001，4，： | 1 |
| 14 | Integrating urbanization into landscape-level ecological assessments显示文摘 | Jeffrey D K Alissa M Ralph J A | 2001 | Ecosystem2001，，4： | 1 |
| 15 | Integrating urbanization into landscape-level ecological assessments显示文摘 | JEFFERY D K ALISSA M RALPH J A | 2001 | Ecosystem2001，，4： | 1 |
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