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| 1 | Grade of donor liver microvesicular steatosis does not affect the postoperative outcome after liver transplantation显示文摘BACKGROUND:The potential effect of graft steatosis on the postoperative liver function is discussed controversially. The present study aimed to evaluate the effect of the donor liver microvesicular steatosis on the postoperative outcome after liver transplantation.METHODS:Ninety-four patients undergoing liver transplantation at the University Hospital Aachen were included in this study. The patient cohort was divided into three groups according to the grade of microvesicular steatosis(MiS):MiS <30%(n=27), MiS 30%-60%(n=41) and MiS >60%(n=26).The outcomes after liver transplantation were evaluated, including the 30-day and 1-year patient and graft survival rates and the incidences of early allograft dysfunction(EAD) and primary nonfunction(PNF). RESULTS:The incidences of EAD and PNF did not differ significantly between the groups. We observed 5 cases of PNF,one occurred in the MiS <30% group and 4 in the MiS 30%-60% group. The 30-day and 1-year graft survivals did not differ significantly between groups. The 30-day patient survival rates were 100% in all groups. The 1-year patient survival rates were 94.4% in the MiS <30% group, 87.9% in the MiS 30%-60% group and 90.9% in the MiS >60% group.CONCLUSION:Microvesicular steatosis of donor livers has no negative effect on the postoperative outcome after liver transplantation. | Anne Andert Tom Florian Ulmer Wenzel Schoning Daniela Kroy Marc Hein Patrick Hamid Alizai Christoph Heidenhain Ulf Neumann Maximilian Schmeding | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，6： | 7 |
| 2 | Comparative study of the effects of terlipressin versus splenectomy on liver regeneration after partial hepatectomy in rats显示文摘BACKGROUND: Post-hepatectomy liver failure as a result of insufficient liver remnant is a feared complication in liver surgery. Efforts have been made to find new strategies to support liver regeneration. The aim of this study was to investigate the effects of terlipressin versus splenectomy on postoperative liver function and liver regeneration in rats undergoing 70%partial hepatectomy. METHODS: Seventy-two male Wistar rats were randomly assigned into three groups(n=24 in each group): 70% partial hepatectomy as control(PHC), 70% partial hepatectomy with splenectomy(PHS) or 70% partial hepatectomy with a micropump for terlipressin administration(PHT). Eight rats in each group were sacrificed on postoperative day(POD) 1,3 and 7. To assess liver regeneration, immunohistochemical analysis of liver tissue using bromodeoxyuridine(BrdU) and Ki-67 labeling was performed. Portal venous pressure, serum concentrations of creatinine, urea, albumin, bilirubin and prothrombin time as well as liver-, body-weight and their ratio were determined on POD 1, 3 and 7.RESULTS: The liver-, body-weight and their ratio were not statistically different among the groups. On POD 1, 3 and 7 portal venous pressure in the intervention groups(PHT:8.13 ±1.55, 10.38±1.30, 6.25±0.89 cm H_2O and PHS: 7.50±0.93,8.88 ±2.42, 5.75±1.04 cm H_2O) was lower compared to the control group(PHC: 8.63±2.06, 10.50±2.45, 6.50±2.67 cmH_2O). Hepatocyte proliferation in the intervention groups was delayed, especially after splenectomy on POD 1(Brd U: PHS vs PHC, 20.85% ±13.05% vs 28.11%±10.10%; Ki-67, 20.14%±14.10% vs 23.96% ±11.69%). However, none of the differences were statistically significant.CONCLUSIONS: Neither the administration of terlipressin nor splenectomy improved liver regeneration after 70% partial hepatectomy in rats. Further studies assessing the regulation of portal venous pressure as well as extended hepatectomy animal models and liver function tests will help to further investigate mechanisms of liver regeneration. | Tom Florian Ulmer Anne Weiland Georg Lurje Christian Klink Anne Andert Hamid Alizai Christoph Heidenhain Ulf Neumann | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，5： | 3 |
| 3 | Mesenchymal hamartoma of the liver:a systematic review显示文摘 | Stringer MD Alizai NK | 2005 | J Pediatr Surg2005，40，11： | 1 |
| 4 | Baseline mean and heterogenei- ty of MR cartilage T2 are associated with morphologie degeneration of cartilage, meniscus, and bone marrow over 3 years--data from the Osteoarthritis Initiative 显示文摘 | Joseph GB Baum T Alizai H | 2012 | Osteoarthritis Cartilage2012，20，： | 1 |
| 5 | Biomechanical analyses of prosthetic mesh repair in a hiatal hernia model显示文摘 | Patrick Hamid Alizai Sofie Schmid Jens Otto Christian Daniel Klink Anjali Roeth Jochen Nolting Ulf Peter Neumann Uwe Klinge | 2014 | J. Biomed. Mater. Res2014，，7： | 1 |
| 6 | Lumbosacral tran-sitional vertebrae: association with low back pain 显示文摘 | Nardo L Alizai H Virayavanich W | 2012 | Radiolo-gy2012，265，2： | 1 |
| 7 | Physical activity in relation to knee cartilage T2 progression measured with 3 T MRI over a period of 4 years:data from the Osteoarthritis Initiative显示文摘 | Lin W Alizai H Joseph GB | 2013 | Osteoarthritis Cartilage2013，21，： | 1 |
| 8 | Baseline mean and heterogeneity of MR cartilage T2 are associated with morphologic degeneration of cartilage,meniscus,and bone marrow over 3 years data from the Osteoarthritis Initiative显示文摘 | Joseph GB Baum T Alizai H | | 0，，7： | 1 |
| 9 | Mesenchymal hamartoma of the liver: a systematic review显示文摘 | ]Stringer MD Alizai NK | 2005 | J Pediatr Surg2005，40，11： | 1 |
| 10 | Lumbosacral transitional vertebrae:association with low back pain显示文摘 | Nardo L Alizai H Virayavanich W | | 0，，02： | 1 |
| 11 | Mesenehymal hamartoma of the liver: a systematic review 显示文摘 | Stringer MD Alizai NK | 2005 | J Pediatr Surg2005，40，11： | 1 |
| 12 | Mesenchymal hamartoma of the liver: a systematic review显示文摘 | Mark D. Stringer Naved K. Alizai | | Journal of Pediatric Surgery0，，： | 1 |
| 13 | Comparison of Long-Term Biocompability of PVDF and PP Meshes显示文摘 | C. D. Klink K. Junge M. Binneb? sel H. P. Alizai J. Otto U. P. Neumann U. Klinge | 2011 | Journal of Investigative Surgery2011，，： | 1 |
| 14 | Mesenchymal hamartoma of the liver: a systematic review显示文摘 | Stringer MD Alizai NK | 2005 | J Pediatr Surg2005，40，11： | 1 |
| 15 | Baseline mean and heterogeneity of MR cartilage T2 are associated with morphologic degeneration of cartilage,meniscus,and bone marrow over 3 years--data from the Osteoarthritis Initiative显示文摘 | Joseph GB Baum T Alizai H | | 0，，07： | 1 |
| 16 | The significance of reed beds on siltation in the Tay estuary 显示文摘 | ALIZAI S A K MCMANUS J | 1980 | Proceedings of the Royal Society Edinburgh1980，78，： | 1 |
| 17 | Robol-assisted re- section of choledochal cysts and hepaticojejunostomy in children less than 10 kg 显示文摘 | Dawrant MJ Najmaldin AS Alizai NK | 2010 | J Pediatr Surg2010，45，12： | 1 |
| 18 | Baseline mean and heterogeneity of MR cartilage T2 are associated with morphologic degeneration of cartilage, meniscus, and bone marrow over 3 years data from the Osteoarthritis Initia- tive显示文摘 | Joseph GB Baum T Alizai H | 2012 | Osteoarthritis Cartilage2012，20，7： | 1 |
| 19 | Biliary atresia in England and Wales: results of centralization and new benchmark显示文摘 | Mark Davenport Evelyn Ong Khalid Sharif Naved Alizai Patricia McClean Nedim Hadzic Deirdre A. Kelly | 2011 | Journal of Pediatric Surgery2011，，9： | 1 |
| 20 | The significance of reed beds on siltation in the Tay estuary显示文摘 | Alizai S A K Mcmanus J | 1980 | Proceedings of the Royal Society Edinburgh1980，78，： | 1 |
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