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| 1 | Trans-arterial chemo-embolization is safe and effective for very elderly patients with hepatocellular carcinoma显示文摘AIM: To assess the safety and efficacy of trans-arterial chemo-embolization (TACE) in very elderly patients. METHODS: A prospective cohort study, from 2001 to 2010, compared clinical outcomes following TACE between patients ≥ 75 years old and younger patients (aged between 65 and 75 years and younger than 65 years) with hepatocellular carcinoma (HCC), diagnosed according to the European Association for the Study of the Liver and the American Association for the Study of Liver Diseases criteria. The decision that patients were not candidates for curative therapy was made by a multidisciplinary HCC team. Data collected included demographics, co-morbidities, liver disease etiology, liver disease severity and the number of procedures. The primary outcome was mortality; secondary outcomes included post-embolization syndrome (nausea, fever, abdominal right upper quadrant pain, increase in liver enzymes with no evidence of sepsis and with a clinical course limited to 3-4 d post procedure) and 30-d complications. Additionally, changes in liver enzyme measurements were assessed [alanine and aspartate aminotransferase (ALT and AST), gamma-glutamyl transpeptidase and alkaline phosphatase] in the week following TACE. Analysis employed both univariate and multivariate methods (Cox regression models). RESULTS: Of 102 patients who underwent TACE as sole treatment, 10 patients (9.8%) were > 80 years old at diagnosis; 13 (12.7%) were between 75 and 80 years, 45 (44.1%) were between 65 and 75 years and 34 (33.3%) were younger than 65 years. Survival analysis demonstrated similar survival patterns between the elderly patients and younger patients. Age was also not associated with the adverse event rate. Survival rates at 1, 2 and 3 years from diagnosis were 74%, 37% and 31% among patients < 65 years; 83%, 66% and 48% among patients aged 65 to 75 years; and 86%, 41% and 23% among patients ≥ 75 years. There were no differences between the age groups in the pre-procedural care, including preventive treatment for contrast nephropathy and prophylactic antibiotics. Multivariate survival analysis, controlling for disease stage at diagnosis with the Barcelona Clinic Liver Cancer score, number of TACE procedures, sex and alphafetoprotein level at the time of diagnosis, found no significant difference in the mortality hazard for elderly vs younger patients, and there were no differences in post-procedural complications. Serum creatinine levels did not change after 55% of the procedures, in all age groups. In 42% of all procedures, serum creatinine levels increased by no more than 25% above the baseline levels prior to TACE. Overall, there were 69 post-embolization events (23%). Hepatocellular enzymes often increased following TACE, with no association with prognosis. In 40% of the procedures, ALT and AST levels rose by at least 100%. The increases in hepatocellular enzymes occurred similarly in all age groups. CONCLUSION: TACE is safe and effective in very elderly patients with HCC, and is not associated with decreased survival or increased complication rates. | Matan J Cohen Allan I Bloom Orly Barak Alexander Klimov Tova Nesher Daniel Shouval Izhar Levi Oren Shibolet | 2013 | World Journal of Gastroenterology2013，19，16： | 13 |
| 2 | 利用腰围身高比预测有雄激素缺乏症的老年男性体内血清睾酮水平显示文摘老年男性血清睾酮的下降可能部分是由肥胖引起的,但是,还不能确定哪些肥胖相关的参数与睾酮水平最密切相关。我们研究过伴有雄激素缺乏症但健康状况良好的老年男性的年龄、肥胖和睾酮水平的关系。本研究中,我们从社区中募集了54岁以上无痛症或其他严重疾病的非吸烟男性做横向研究分析,测定身高,体重和腰围,并计算体质指数(BMI)和腰围身高比(WHt)。收集两个早上的血液样本,测量总睾酮,性激素结合球蛋白和促黄体激素。计算游离睾酮(cFT)。并对上述指标与肥胖参数之间的关系进行多元线性凹归分析。207名54-86岁之间的男性参与了此次研究。单因素分析结果表明腰围身高比与睾酮和游离睾酮的相关性明显高于体重和腰吲或体质指数。另外,对总睾酮和游离睾酮来说,体重和腰围以及身高都有重要意义(所有的P均小于0.05),身高值中加入体重和腰围值后,导致体重和腰用以及身高的回归系数都增加了,其中腰围呈负相关,身高呈正相关。总之,腰围身高比是预测健康但有雄激素缺乏症的老年男性的睾酮和游离睾酮最好的体质指标。 | Carolyn A Allan Roger E Peverill Boyd JG Strauss Elise A Forbes Robert I McLachlan | 2011 | Asian Journal of Andrology2011，13，3： | 3 |
| 3 | A reliability test system for education purposes: basic distribution system data and results 显示文摘 | ALLAN R N BILLINTON R SJARIEF I | 1991 | IEEE Transaction Power Systems1991，6，2： | 1 |
| 4 | The agreement between cervical abnormalities identified by cytology and detection of highrisk types of human papillomavirus显示文摘 | Allan B R Marais D I Denny L | 2006 | S Afr Med J2006，96，11： | 1 |
| 5 | Simulation of radiation damage in gadolinium pyrochlores显示文摘 | TODOROV I T PURTON J A ALLAN N | 2006 | J Phys:Condens Matter2006，18，： | 1 |
| 6 | Object localisation using the generative template of features显示文摘 | Allan M Williams C K I | 2009 | Computer Vision and Image Understanding2009，113，7： | 1 |
| 7 | A reliability test system for educational pruposes-basic distribution system data and results显示文摘 | Allan R N Billinton R Sjarief I | 1991 | IEEE Trans on Power System1991，6，2： | 1 |
| 8 | High temperature reduces apple fruit colour via modulation of the anthocyanin regulatory complex显示文摘 | Wang L K Micheletti D Palmer J Volz R Lozano L Espley R Hellens R P Chagn6 D Rowan D D Troggio M Iglesias I Allan A C | 2011 | Plant Cell & Environment2011，34，： | 1 |
| 9 | Isolation and characterization of porcine circovirus 2 from cases of sow abortion and porcine dermatitis and nephropathy syndrome 显示文摘 | Meehan BM McNeilly F McNair I Walker I Ellis JA Krakowka S Allan GM | 2001 | Arch Virol2001，146，4： | 1 |
| 10 | Antibacterial activity of particulate bioglass against supra- and subgingival bacleria 显示文摘 | Allan I Newman H Wilson M | 2001 | Biomaterials2001，22，12： | 1 |
| 11 | The role of human aldehyde dehydrogenase in nor-mal and cancer stem cells显示文摘 | Ma I Allan AL | 2011 | Stem Cell Rev2011，7，2： | 1 |
| 12 | A reliability test system for educational purpose: basic distribution system data and results显示文摘 | Allan R N Billinton R Sjarief I | 1991 | IEEE Transactions on Power System1991，6，2： | 1 |
| 13 | Diffusion of the Synthetic Pyrethroid Permethrin into Bed-sediments显示文摘 | ALLAN I J HOUSE W A PARKER A | 2005 | Environ Sci Technol2005，39，2： | 1 |
| 14 | Strategic monitoring for the European Water Framework Directive 显示文摘 | Allan I Mills G Vrana B | 2006 | Trends in Analytical Chemistry2006，25，7： | 1 |
| 15 | A reliability test system for educational purposes-basic distribution system data and results显示文摘 | Allan R N Billinton R Sjarief I | 1991 | IEEE Transactions on Power Systems1991，6，2： | 1 |
| 16 | Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child显示文摘 | Haddow JE Palomaki GE Allan WC et a I | 1999 | N End J Med1999，341，8： | 1 |
| 17 | Effect of anti prostaglandin therapy in experimental parainfluenza type 3 pneu- monia in weaned, conventional calves 显示文摘 | Selman I E Allan E M Gibbs H A | 1984 | Vet Rec1984，115，5： | 1 |
| 18 | Coxsacklevlruses in normal children显示文摘 | COOK I ALLAN B C WELHAM S | 1969 | Med J Aust1969，2，3： | 1 |
| 19 | Probability of corrosion induced cracking in reinforced concrete 显示文摘 | Allan M I | 1995 | Cement and Concrete Research1995，25，6： | 1 |
| 20 | A reliability test sys- tem for educational purposes-basic distribution system data and results显示文摘 | Allan R N Billinton R Sjarief I etal | 1991 | IEEE Trans on Power Systems1991，6，2： | 1 |
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