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| 1 | Electroporative interleukin-10 gene transfer ameliorates carbon tetrachlo-ride-induced murine liver fibrosis by MMP and TIMP modulation显示文摘瞄准:肝纤维变性代表响应长期的肝损伤愈合并且结疤的一个过程。为肝纤维变性的有效治疗正在缺乏。Interleukin-10 (IL-10 ) 是 cytokine 下面调整支持 inflammatory 回答并且在肝的纤维发生上有调节效果。这研究的目的是调查 electroporative IL-10 基因治疗是否在老鼠上有肝的 fibrolytic 效果。方法:肝的纤维变性被在老鼠管理四氯化碳(CCl4 ) 10 个星期导致。在肝的纤维变性被建立以后,人的 IL-10 表示原生质标志经由 electroporation 被交付。组织病理学说,反向的抄写聚合酶链反应(RT-PCR ) ,弄污的免疫,和明胶 zymography 被用来调查 IL-10 的行动的可能的机制。结果:人的 IL-10 基因治疗在老鼠颠倒了导致 CCl4 的肝纤维变性。RT-PCR 表明那 IL-10 基因治疗稀释了肝 TGF-beta1,骨胶原 alpha1, fibronectin,和房间粘附分子在规定上面的 mRNA。后面的基因转移,两个都, alpha 光滑的肌肉肌动朊和 cyclooxygenase-2 的激活显著地被稀释。而且, IL-10 显著地禁止了矩阵 metalloproteinase-2 (MMP-2 ) 和矩阵 metalloproteinase (TIMP ) 的织物禁止者在 CCl4 沉醉以后的激活。结论:我们证明那 IL-10 基因治疗在老鼠稀释了导致 CCl4 的肝纤维变性。在调整 fibrogenic 和支持 inflammatory 基因回答上面阻止的 IL-10。它的溶胶原效果可以被归因于 MMP 和 TIMP 调整。IL-10 基因治疗可以是对有潜在的临床的使用的肝纤维变性的一种有效治疗学的形式。 | Wen-ying CHOU Cheng-nan LU Tsung-hsing LEE Chia-ling WU Kung-sheng HUNG Allan M CONCEJERO Bruno JAWAN Cheng-haung WANG | 2006 | Acta Pharmacologica Sinica2006，27，4： | 25 |
| 2 | Cellular response to influenza virus infection: a potential role for autophagy in CXCL10 and interferon-alpha induction显示文摘Historically,influenza pandemics have arisen from avian influenza viruses.Avian influenza viruses H5N1 and H9N2 are potential pandemic candidates.Infection of humans with the highly pathogenic avian influenza H5N1 virus is associated with a mortality in excess of 60%,which has been attributed to dysregulation of the cytokine system.Human macrophages and epithelial cells infected with some genotypes of H5N1 and H9N2 viruses express markedly elevated cytokine and chemokine levels when compared with seasonal influenza A subtype H1N1 virus.The mechanisms underlying this cytokine and chemokine hyperinduction are not fully elucidated.In the present study,we demonstrate that autophagy,a tightly regulated homeostatic process for self-digestion of unwanted cellular subcomponents,plays a role in cytokine induction.Autophagy is induced to a greater extent by H9N2/G1,in association with cytokine hyperinduction,compared with H1N1 and the novel pandemic swine-origin influenza A/H1N1 viruses.Using 3-methyladenine to inhibit autophagy and small interfering RNA to silence the autophagy gene,Atg5,we further show that autophagic responses play a role in influenza virus-induced CXCL10 and interferon-a expression in primary human blood macrophages.Our results provide new insights into the pathogenic mechanisms of avian influenza viruses. | Anna Hing-Yee Law Davy Chun-Wai Lee Kwok-Yung Yuen Malik Peiris Allan Sik-Yin Lau | 2010 | Cellular & Molecular Immunology2010，7，4： | 7 |
| 3 | Magnetic resonance imaging manifestations of cerebral small vessel disease:automated quantification and clinical application显示文摘The common cerebral small vessel disease(CSVD)neuroimaging features visible on conventional structural magnetic resonance imaging include recent small subcortical infarcts,lacunes,white matter hyperintensities,perivascular spaces,microbleeds,and brain atrophy.The CSVD neuroimaging features have shared and distinct clinical consequences,and the automatic quantification methods for these features are increasingly used in research and clinical settings.This review article explores the recent progress in CSVD neuroimaging feature quantification and provides an overview of the clinical consequences of these CSVD features as well as the possibilities of using these features as endpoints in clinical trials.The added value of CSVD neuroimaging quantification is also discussed for researches focused on the mechanism of CSVD and the prognosis in subjects with CSVD. | Lei Zhao Allan Lee Yu-Hua Fan Vincent C.T.Mok Lin Shi | 2021 | Chinese Medical Journal2021，，2： | 3 |
| 4 | Lifestyle factors and the risk of varicose veins: Edinburgh Vein Study 显示文摘 | Lee AJ Evans CJ Allan PL | 2003 | J Clin Epidemiol2003，56，： | 1 |
| 5 | Avian influenza virus signaling: implications for the disease severity of H5N1 infection 显示文摘 | Lee D C W Allan S Y | 2007 | Signal Transduction2007，7，： | 1 |
| 6 | Bibliography on the application of probability methods in power system reliability evaluation 1977-1982显示文摘 | Allan R N Billinton R Lee S H | 1984 | IEEE Trans on Power Apparatus and Systems1984，，： | 1 |
| 7 | The first data from the Orion laser; measurements of the spectrum of hot, dense aluminium显示文摘 | D.J. Hoarty P. Allan S.F. James C.R.D. Brown L.M.R. Hobbs M.P. Hill J.W.O. Harris J. Morton M.G. Brookes R. Shepherd J. Dunn H. Chen E. Von Marley P. Beiersdorfer H.K. Chung R.W. Lee G. Brown J. Emig | 2013 | High Energy Density Physics2013，，4： | 1 |
| 8 | A rapid aflatoxin B1ELISA:development and validation with reduced ma- trix effects for peanuts, corn, pistachio, and soybean 显示文摘 | Lee N A Wang S Allan R D | 2004 | Agrie Food Chem2004，52，10： | 1 |
| 9 | Relationship between carotid IMT and symptomatic and asymptomatic peripheral arterial disease显示文摘 | Allan PL Mowbray Lee AJ | 1997 | Stroke1997，28，： | 1 |
| 10 | PID control for a distributed system with a smart actuator 显示文摘 | Lee D Allan J Thompson H A Bennett S | 2001 | Control Engineering Practice2001，9，11： | 1 |
| 11 | Thompson, Stuart Bennett, PID control for a distributed system显示文摘 | Dongik Lee Jeff Allan Haydn A | 2001 | Control Engineering Practice2001，，9： | 1 |
| 12 | ISUOG consensus statement: what constitutes a fetal echocardiogram? 显示文摘 | Lee W Allan L Carvalho JS | 2008 | Ultrasound Obstet Gynecol2008，32，2： | 1 |
| 13 | PID control for a distributed system with a smart actuator显示文摘 | Lee D Allan J Thompson H A | 2001 | Control Engineering Practice2001，9，： | 1 |
| 14 | Relationship between carotid intima media thickness and symptomatic and asymptomatie peripheral arterial disease显示文摘 | Allan PL Mowbray PI Lee AJ | 1997 | The Edinburgh Artery study stroke1997，28，2： | 1 |
| 15 | Sedation Depth During Spinal Anesthesia and the Development of Postoperative Delirium in Elderly Patients Undergoing Hip Fracture Repair显示文摘 | Frederick E. Sieber Khwaji J. Zakriya Allan Gottschalk Mary-Rita Blute Hochang B. Lee Paul B. Rosenberg Simon C. Mears | 2010 | Mayo Clinic Proceedings2010，，1： | 1 |
| 16 | Comparison of nonideal sorption formulations in modeling the transport of phthalate esters through packed soil columns显示文摘 | Munjed A. Maraqa Xianda Zhao Jae-ug Lee Fathi Allan Thomas C. Voice | 2011 | Journal of Contaminant Hydrology2011，，1： | 1 |
| 17 | ISUOG consensus statement:what constitutes a fetal echocardiogram[J]显示文摘 | Lee W Allan L Carvalho J S | | 0，，02： | 1 |
| 18 | Relationship between carotid-media thickness and symptomatic and asyruptomatic peripheral arterial disease 显示文摘 | Allan PL Mowbray PI Lee A J | 1997 | The Edinburgh Artery Study1997，28，： | 1 |
| 19 | Lifestyle factors and the risk of varicose veins:Edinburgh Vein Study显示文摘 | Lee AJ Evans CJ Allan PL | 2003 | Clin Epidemiol2003，56，2： | 1 |
| 20 | Prevalence of venous reflux in the general population on duplex scanning:the Edinburgh vein study 显示文摘 | Evans C J Allan PL Lee AJ | 1998 | J Vasc Surg1998，28，： | 1 |
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