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| 1 | Routine diagnosis of intestinal tuberculosis and Crohn's disease in Southern India显示文摘AIM:To investigate whether routinely measured clinical variables could aid in differentiating intestinal tuberculosis(ITB)from Crohn’s disease(CD).METHODS:ITB and CD patients were prospectively included at four South Indian medical centres from October 2009 to July 2012.Routine investigations included case history,physical examination,blood biochemistry,ileocolonoscopy and histopathological examination of biopsies.Patients were followed-up after 2 and 6 mo of treatment.The diagnosis of ITB or CD was re-evaluated after 2 mo of antituberculous chemotherapy or immune suppressive therapy respectively,based on improvement in signs,symptoms and laboratory variables.This study was considered to be an exploratory analysis.Clinical,endoscopic and histopathological features recorded at the time of inclusion were subject to univariate analyses.Disease variables with sufficient number of recordings and P<0.05 were entered into logistic regression models,adjusted for known confounders.Finally,we calculated the odds ratios with respective confidence intervals for variables associated with either ITB or CD.RESULTS:This study included 38 ITB and 37 CD patients.Overall,ITB patients had the lowest body mass index(19.6 vs 22.7,P=0.01)and more commonly reported weight loss(73%vs 38%,P<0.01),watery diarrhoea(64%vs 33%,P=0.01)and rural domicile(58%vs 35%,P<0.05).Endoscopy typically showed mucosal nodularity(17/31 vs 2/37,P<0.01)and histopathology more frequently showed granulomas(10/30vs 2/35,P<0.01).The CD patients more frequently reported malaise(87%vs 64%,P=0.03),nausea(84%vs 56%,P=0.01),pain in the right lower abdominal quadrant on examination(90%vs 54%,P<0.01)and urban domicile(65%vs 42%,P<0.05).In CD,endoscopy typically showed involvement of multiple intestinal segments(27/37 vs 9/31,P<0.01).Using logistic regression analysis we found weight loss and nodularity of the mucosa were independently associated with ITB,with adjusted odds ratios of 8.6(95%CI:2.1-35.6)and 18.9(95%CI:3.5-102.8)respectively.Right lower abdominal quadrant pain on examination and involvement of≥3 intestinal segments were independently associated with CD with adjusted odds ratios of 10.1(95%CI:2.0-51.3)and 5.9(95%CI:1.7-20.6),respectively.CONCLUSION:Weight loss and mucosal nodularity were associated with ITB.Abdominal pain and excessive intestinal involvement were associated with CD.ITB and CD were equally common. | Geir Larsson Thrivikrama Shenoy Ramalingom Ramasubramanian Leena Kondarappassery Balakumaran Milada Cvancarova Smstuen Gunnar Aksel Bjune Bjφrn Allan Moum | 2014 | World Journal of Gastroenterology2014，20，17： | 5 |
| 2 | The interleukin-l system:an attractive and viable therapeutic target in neurodegenerative disease显示文摘 | Allan SM Pinteaux E | 2003 | Curt Drug Target CNS Neurol Disord2003，2，5： | 1 |
| 3 | Beta (3) integrin expression increases breast carcinoma cell responsiveness to the malignancy-enhancing effects of osteopontin显示文摘 | Furger KA Allan AL Wilson SM | 2003 | Mol Cancer Res2003，1，11： | 1 |
| 4 | Interleukin -1 in the brain:mechanisms of action in acute neu rodegeneration显示文摘 | Patel HC Boutin H Allan SM | | 0，，： | 1 |
| 5 | Beta(3)integrin expression increases breast carcinoma cell responsiveness to the malignancy-enhancing effects of osteopontin显示文摘 | Furger KA Allan AL Wilson SM | | 0，，11： | 1 |
| 6 | Cortical cell death induced by IL-1 is mediated via actions in the hypotha- lamus of the rat显示文摘 | ALLAN SM PARKERL C COLLINS B | 2000 | Proc Natl Acad Sci USA2000，97，10： | 1 |
| 7 | Beta(3) integrin expression increase breast carcinoma cell responsive to the malignancy-enhancing effects of osteopontin显示文摘 | Fruger KA Allan AL Wilson SM | 2003 | Mol-Cancer-Res2003，1，11： | 1 |
| 8 | Cytokines and acute neu- rodegeneration 显示文摘 | Allan SM Rothwell NJ | 2001 | Nat Rev Neurosci2001，2，10： | 1 |
| 9 | Radioimmunolocalisation in breast cancer using the gene product of c - erbB2 as the target antigen显示文摘 | Allan SM Dean C Fernando I | 1993 | Br J Cancer1993，67，4： | 1 |
| 10 | Assessing the contribution of inflamma- tion in models of Alzheimer' s disease 显示文摘 | in Johnston H Boutin H Allan SM | 2011 | Biochem Soc Trans2011，39，4： | 1 |
| 11 | Systemic inflammatory stimulus potentiates the acute phase and CXC chemokine responses to experimental stroke and exacerbates brain damage via interleukin-1-and neutrophil-dependent mechanisms显示文摘 | McColl BW Rothwell NJ Allan SM | 2007 | J Neurosci2007，27，16： | 1 |
| 12 | Inflammation in central nervous system injury 显示文摘 | Allan SM Rothwell NJ | 2003 | Phil Trans R Soc Land B Biol Sci2003，358，1438： | 1 |
| 13 | Cortical cell death induced IL-1 is mediated via actions in the hypothalamus of the rat显示文摘 | Allan SM Parker LC Collins B | 2000 | Proc Natl Acad Sci USA2000，97，10： | 1 |
| 14 | Cytokine and acute neurodegeneration 显示文摘 | Allan SM Rothwell NJ | 2001 | Nat Rev2001，2，10： | 1 |
| 15 | Beta(3) integrin expression increases breast carcinoma cell responsiveness to the malignancy-enhancing effects of osteopontin显示文摘 | Furger KA Allan AL Wilson SM | 2003 | Mol Cancer Res2003，1，11： | 1 |
| 16 | Interleukin-1 and neuronal injury显示文摘 | Allan SM Tyrrell PJ Rothwell NJ | 2005 | Nat Rev Immunol2005，5，： | 1 |
| 17 | Intedeukin-1 and neuronal in- jury显示文摘 | Allan SM Tyrrell PJ Rothwell NJ | 2005 | Nat Rev Immunol2005，5，8： | 1 |
| 18 | Interleukin-1 in the brain: mechanisms of action in acute neurodegeneration显示文摘 | Patel HC Boutin H Allan SM | 2003 | Ann N Y Acad Sci2003，992，： | 1 |
| 19 | Systemic infection,inflammation and acute ischemic stroke显示文摘 | McColl BW Allan SM Rothwell NJ | 2009 | Neuroscience2009，158，3： | 1 |
| 20 | Interleukin-1 and Neuronal Injury显示文摘 | ALLAN SM TYRRELL PJ ROTHWELL NJ | 2005 | Nat Rev Immunol (S1474-1733)2005，5，： | 1 |
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