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3篇 您的检索式：作者名="Allan Yuen"

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		题名	作者	年代	出处	被引量
	1	Cellular response to influenza virus infection: a potential role for autophagy in CXCL10 and interferon-alpha induction显示文摘Historically,influenza pandemics have arisen from avian influenza viruses.Avian influenza viruses H5N1 and H9N2 are potential pandemic candidates.Infection of humans with the highly pathogenic avian influenza H5N1 virus is associated with a mortality in excess of 60%,which has been attributed to dysregulation of the cytokine system.Human macrophages and epithelial cells infected with some genotypes of H5N1 and H9N2 viruses express markedly elevated cytokine and chemokine levels when compared with seasonal influenza A subtype H1N1 virus.The mechanisms underlying this cytokine and chemokine hyperinduction are not fully elucidated.In the present study,we demonstrate that autophagy,a tightly regulated homeostatic process for self-digestion of unwanted cellular subcomponents,plays a role in cytokine induction.Autophagy is induced to a greater extent by H9N2/G1,in association with cytokine hyperinduction,compared with H1N1 and the novel pandemic swine-origin influenza A/H1N1 viruses.Using 3-methyladenine to inhibit autophagy and small interfering RNA to silence the autophagy gene,Atg5,we further show that autophagic responses play a role in influenza virus-induced CXCL10 and interferon-a expression in primary human blood macrophages.Our results provide new insights into the pathogenic mechanisms of avian influenza viruses.	Anna Hing-Yee Law Davy Chun-Wai Lee Kwok-Yung Yuen Malik Peiris Allan Sik-Yin Lau	2010	Cellular & Molecular Immunology2010，7，4：	7
	2	Course Management Systems in Higher Education: Understanding Student Experiences 显示文摘	Allan Yuen Robert Fox Angle Sun Liping Deng	2009	Interactive Technology and Smart Education2009，，3：	1
	3	Understanding on- line knowledge sharing: An interpersonal relationship perspective 显示文摘	Will W K Maa Allan H K Yuen	2011	Computers &Education2011，56，2：	1

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