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| 1 | High adiponectin levels fail to protect against the risk of hypertension and,in women,against coronary disease:involvement in autoimmunity?显示文摘AIM:To investigate whether serum adiponectin protects against cardiometabolic risk in a population sample with prevailing metabolic syndrome.METHODS:Middle-aged adults representative of a general population with baseline circulating adiponectin measurements(n=1224)were analyzed prospectively at a mean of 3.8 years’follow-up,using continuous values or sex-specific tertiles.Total adiponectin was assayed by an ELISA kit.Type-2 diabetes was identified by criteria of the American Diabetes Association.Hypertension was defined as a blood pressure≥140 mmHg and/or≥90 mmHg and/or use of antihypertensive medication.Outcomes were predicted using Cox proportional hazards regression analysis in models that were controlled for potential confounders.RESULTS:In models of multiple linear regression,sex hormone-binding globulin,fasting insulin(inverse)and,in men,age were significant independent covariates of serum adiponectin which further tended in women to be positively associated with serum creatinine.Cox regression analyses for incident coronary heart disease(CHD),adjusted for sex,age,non-HDL cholesterol,waist circumference and C-reactive protein,revealed significant inverse association with adiponectin tertiles in men but not women(HR=0.66;95%CI:0.32-1.38 for highest tertile).Cox regression for type-2 diabetes in a similar model(wherein glucose replaced non-HDL cholesterol),adiponectin tertiles appeared to protect in each gender.HR for incident hypertension roughly displayed unity in each of the adiponectin tertiles(P-trend=0.67).CONCLUSION:High adiponectin levels failed to protect against the development of hypertension and,in women,against CHD,presumably paralleling impairment in renal function as well.Involvement of adiponectin in autoimmune complex with loss of antioxidative-antiatherogenic properties may be underlying. | Altan Onat Mesut Aydln Günay Can Bayram Kroglu Ahmet Karagz Servet Altay | 2013 | World Journal of Diabetes2013，4，5： | 3 |
| 2 | Molecular detection of Theileria and Babesia infections in cattle 显示文摘 | Altay K Aktas M | 2008 | Veterinary Parasitology2008，158，4： | 1 |
| 3 | Consequences of epididymal ligation on prepubertal rats显示文摘 | Aktug H Ozdedeli K Altay B | 2007 | Anal Quant Cytol Histol2007，29，1： | 1 |
| 4 | PCR-RFLP analysis of the Tamsl gene of Theileria annulata 显示文摘 | Altay K Aktas M Dumanli N | 2007 | Turkiye Parazitol Derg2007，31，： | 1 |
| 5 | Photoselec- tive potassium titanyl-phosphate (KTP) laser vapori zation versus Transurethral resection of the prostate for prostates larger than 70 ml:a short-term prospee rive randomized tria显示文摘 | Horasanli K Silay M S Altay B | 2008 | Urology2008，71，2： | 1 |
| 6 | Photoselective potassium titanyl - phosphate (KTP) laser vaporization versus tansurethral resection of the prostate for prostates larger than 70 ml : a shor - term prospective ran- domized trial显示文摘 | Horasanli K Silay MS Altay B | 2008 | Urology2008，71，2： | 1 |
| 7 | PCR-based detectionof Theileria ovis in Rhipicephalus bursa adult ticks显示文摘 | AKTAS M ALTAY K DUMANLI N | 2006 | VetParasitol2006，140，34： | 1 |
| 8 | Secondary chondrosarcoma in cartilage bone tumors: report of 32 patients显示文摘 | Altay M Bayrakci K Yildiz Y | 2007 | J Orthop Sci2007，12，5： | 1 |
| 9 | Survey of Theileriaparasites of sheep in eastern Turkey using polymerase chainreaction显示文摘 | AKTAS M ALTAY K DUMANLI N | 2005 | Small Rumin Res2005，60，3： | 1 |
| 10 | PCR-base detection of Theileria ovis in Rhipicephalus bursa adult ticks 显示文摘 | Aktas M Altay K Dumanli N | 2006 | Veterinary parasitology2006，140，34： | 1 |
| 11 | The use of poIymethylmethacrylate in the management of hydatid disease of bone显示文摘 | Yildiz Y Bayrakci K Altay M | 2001 | J Bone Joint Surg Br2001，83，7： | 1 |
| 12 | Inhibition of Rho kinase by hydroxyfasudil attenuates brain edema after subarachnoid hemorrhage in rats显示文摘 | Fujii M Duffs K Altay O | 2012 | Neurochem Int2012，60，3： | 1 |
| 13 | Secondary chondrosareoma in cartilage bone tumors: report of 32 pa- tients显示文摘 | ALTAY M BAYRAKCI K YILDIZ Y | 2007 | J Orthop Sci2007，，12： | 1 |
| 14 | The use of polymethylmethacrylate in the management of hydatid disease of bone显示文摘 | Yildiz Y Bayrakci K Altay M | 2001 | J Bone Joint Surg Br2001，83，7： | 1 |
| 15 | Serum creatinine is associated with coronary disease risk even in the absence of metabolic disorders显示文摘 | Altan Onat Hü sniye Yü ksel Gü nay Can Bayram Kö ro&gbreve lu Ay&scedil em Kaya Servet Altay | 2013 | Scandinavian Journal of Clinical & Laboratory Investigation2013，，7： | 1 |
| 16 | Photoselective potassium titanyl phosphate (KTP) laser vaporization versus transurethral resection of the prostate for prostates larger than 70 ml:A shortterm prospective randomized trial显示文摘 | Horasanli K Silay MS Altay B | | 0，，02： | 1 |
| 17 | Nasal administration of re- combinant osteopontin attenuates early brain injury after sub- arachnoid hemorrhage 显示文摘 | Topkoru BC Altay O Duris K | 2013 | Stroke2013，44，11： | 1 |
| 18 | Effect of being overweight on stone-forming risk factors 显示文摘 | Sarica K Altay B Erturhan S | 2008 | Urology2008，71，5： | 1 |
| 19 | Survey of Theileriaparasites of sheep in eastern Turkey using polymerase chainreaction显示文摘 | AKTAS M ALTAY K DUMANLI N | 2005 | Small Rumin Res2005，60，3： | 1 |
| 20 | Photoseleetive potassium tit- anyl phosphate (KTP) laser vaporization versus transurethral resec- tion of the prostate for prostates larger than 70 mL: a short-term prospective randomized trial显示文摘 | Horasanli K Silay MS Altay B | 2008 | Urology2008，71，2： | 1 |
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