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| 1 | Spontaneous rupture of hepatic hemangiomas:A review of the literature显示文摘Hepatic hemangiomas are congenital vascular malformations,considered the most common benign mesenchymal hepatic tumors,composed of masses of blood vessels that are atypical or irregular in arrangement and size. Hepatic hemangiomas can be divided into two major groups:capillary hemangiomas and cavernous hemangiomas These tumors most frequently affect females (80%) and adults in their fourth and fifth decades of life. Most cases are asymptomatic although a few patients may present with a wide variety of clinical symptoms,with spontaneous or traumatic rupture being the most severe complication. In cases of spontaneous rupture,clinical manifestations consist of sudden abdominal pain,and anemia secondary to ahaemoperitoneum. Disseminated intravascular coagulopathy can also occur. Haemodynamic instability and signs of hypovolemic shock appear in about one third of cases. As the size of the hemangioma increases,so does the chance of rupture. Imaging studies used in the diagnosis of hepatic hemangiomas include ultrasonography,dynamic contrast-enchanced computed tomography scanning,magnetic resonance imaging,hepatic arteriography,digital subtraction angiography,and nuclear medicine studies. In most cases hepatic hemangiomas are asymptomatic and should be followed up by means of periodic radiological examination. Sur gery should be restricted to specific situations. Absolute indications for surgery are spontaneous or trau m atic rupture with hemoperitoneum,intratumoral blee ding and consumptive coagulopathy (Kassabach-Merrit syndrome). In a patient presenting with acute abdo minal pain due to unknown abdominal disease,sponta neous rupture of a hepatic tumor such as a hemangio ma should be considered as a rare differential diagnosis. | Marcelo AF Ribeiro Francine Papaiordanou Juliana M Gonalves Eleazar Chaib | 2010 | World Journal of Hepatology2010，2，12： | 12 |
| 2 | Characterization of monocarboxylate transporter activity in hepatocellular carcinoma显示文摘AIM: To assess the immunoexpression of hypoxiarelated markers in samples from cirrhosis and primary and metastatic hepatocellular carcinoma(HCC).METHODS: From a total of 5836 autopsies performed at the Pathology Department- University of Sao Paulo School of Medicine Hospital- from 2003 to 2009, 188 presented primary liver tumors. Immunohistochemical reactivity for monocarboxylate transporters(MCTs)-1, 2 and 4, CD147 and glucose transporter-1(GLUT1)was assessed in necropsies from 80 cases of HCC. Data were stored and analyzed using the IBM SPSS statistical software(version 19, IBM Company, Armonk, NY). All comparisons were examined for statistical significance using Pearson's χ2 test and Fisher's exact test(when n < 5). The threshold for significant P values was established as P < 0.05.RESULTS: Plasma membrane expression of MCT4 and overall expression of GLUT1 showed progressively higher expression from non-neoplastic to primary HCC and to metastases. In contrast, overall expression of MCT2 was progressively decreased from non-neoplastic to primary HCC and to metastases. MCT1(overall and plasma membrane expression), MCT2 and CD147 plasma membrane expression were associated with absence of cirrhosis, while plasma membrane expression of CD147 was also associated with absence of HBV infection. MCT2 overall expression was associated with lower liver weight, absence of metastasis and absence of abdominal dissemination. Additionally, MCT4 plasma membrane positivity was strongly associated with Ki-67 expression. CONCLUSION: MCT4 and GLUT1 appear to play a role in HCC progression, while MCT2 is lost during progression and associated with better prognosis. | Venncio AF Alves Céline Pinheiro Filipa Morais-Santos Aloisio Felipe-Silva Adhemar Longatto-Filho Fátima Baltazar | 2014 | World Journal of Gastroenterology2014，20，33： | 11 |
| 3 | Percutaneous radiofrequency ablation for early hepatocellular carcinoma: Risk factors for survival显示文摘AIM: To evaluate outcomes of radiofrequency ablation(RFA) therapy for early hepatocellular carcinoma(HCC) and identify survival- and recurrence-related factors. METHODS: Consecutive patients diagnosed with early HCC by computed tomography(CT) or magnetic resonance imaging(MRI)(single nodule of ≤ 5 cm, or multi-(up to 3) nodules of ≤ 3 cm each) and who underwent RFA treatment with curative intent between January 2010 and August 2011 at the Instituto do Cancer do Estado de S o Paulo, Brazil were enrolled in the study. RFA of the liver tumors(with 1.0 cm ablative margin) was carried out under CT-fluoro scan and ultrasonic image guidance of the percutaneous ablation probes. Procedure-related complications were recorded. At 1-mo post-RFA and 3-mo intervals thereafter, CT and MRI were performed to assess outcomes of complete response(absence of enhancing tissue at the tumor site) or incomplete response(enhancing tissue remaining at the tumor site). Overall survival and diseasefree survival rates were estimated by the Kaplan-Meier method and compared by the log rank test or simple Cox regression. The effect of risk factors on survival was assessed by the Cox proportional hazard model. RESULTS: A total of 38 RFA sessions were performed during the study period on 34 patients(age in years: mean, 63 and range, 49-84). The mean follow-up time was 22 mo(range, 1-33). The study population showed predominance of male sex(76%), less severe liver disease(Child-Pugh A, n = 26; Child-Pugh B, n = 8), and single tumor(65%). The maximum tumor diameters ranged from 10 to 50 mm(median, 26 mm). The initial(immediately post-procedure) rate of RFAinduced complete tumor necrosis was 90%. The probability of achieving complete response was significantly greater in patients with a single nodule(vs patients with multi-nodules, P = 0.04). Two patients experienced major complications, including acute pulmonary edema(resolved with intervention) and intestinal perforation(led to death). The 1- and 2-year overall survival rates were 82% and 71%, respectively. Sex, tumor size, initial response, and recurrence status influenced survival, but did not reach the threshold of statistical significance. Child-Pugh class and the model for end-stage liver disease score were identified as predictors of survival by simple Cox regression, but only Child-Pugh class showed a statistically significant association to survival in multiple Cox regression analysis(HR = 15; 95%CI: 3-76 mo; P = 0.001). The 1-and 2-year cumulative disease-free survival rates were 65% and 36%, respectively. CONCLUSION: RFA is an effective therapy for local tumor control of early HCC, and patients with preserved liver function are the best candidates. | Luciana Kikuchi Marcos Menezes Aline L Chagas Claudia M Tani Regiane SSM Alencar Marcio A Diniz Venncio AF Alves Luiz Augusto Carneiro D’Albuquerque Flair José Carrilho | 2014 | World Journal of Gastroenterology2014，20，6： | 5 |
| 4 | Local delivery of EGF -liposome mediated bone modeling in orthodontic tooth movement by increasing RANKL expression显示文摘 | Alves JB Ferreira CL Martins AF | 2009 | Life Sci2009，85，920： | 1 |
| 5 | Influence of light source and extended time of curing on microhardness and degree of conversion of different regions of a nanofilled composite resin 显示文摘 | Lima AF de Andrade KM da Cruz Alves LE | 2012 | Eur J Dent2012，6，2： | 1 |
| 6 | A meta-analysis of serious adverse events reported with exenatide and liraglutide:acute pancreatitis and cancer显示文摘 | Alves C Batel-Marques F Macedo AF | | 0，，02： | 1 |
| 7 | A meta-analysis of seri- ous adverse events reported with exenatide and liraglutide: acute pancreatitis and cancer 显示文摘 | Alves C Batel-Marques F Macedo AF | 2012 | Diabetes Res ClinPraet2012，98，2： | 1 |
| 8 | Apixaban and rivaroxaban safety after hip and knee arthroplasty:a meta-analysis 显示文摘 | Alves C Batel-Marques F Macedo AF | 2012 | J Cardiovasc Pharmacol Ther2012，17，3： | 1 |
| 9 | Performance analysis of the Flutter VRP1 under different flows and angles 显示文摘 | Alves LA Pitta F Brunetto AF | 2008 | Respir Care2008，53，3： | 1 |
| 10 | Detection of human parvovirus B19 in a patient with hepatitis 显示文摘 | Pinho JR Alves VA Vieira AF | 2001 | Braz J Med Biol Res2001，34，9： | 1 |
| 11 | A meta-analysis of serious adverse events reported with exenatide and liraglutide: acute pancreatitis and cancer显示文摘 | Alves C Batel-Marques F Macedo AF | 2012 | Diabetes Res Clin Pract2012，98，2： | 1 |
| 12 | Drug-safety alerts issued by regulatory authorities: usefulness of meta-analysis in predicting risks earlier显示文摘 | Alves C Marques FB Macedo AF | 2014 | Eur J Clin Pharmacol2014，70，6： | 1 |
| 13 | Autobiographical memo- ry disturbances in depression: A novel therapeutic target显示文摘 | Kohler CA Carvalho AF Alves GS | 2015 | Neu- ral Plast2015，2015，75： | 1 |
| 14 | A meta-analysis of seri-ous adverse events reported with exenatide and liraglutide : acutepancreatitis and cancer显示文摘 | Alves C Batel-Marques F Macedo AF | 2012 | Diabetes Res Clin Pract2012，98，2： | 1 |
| 15 | Oral administration of S-nitroso-N-acetylcysteine prevents the onset of non alcoholic fatty liver disease in rats显示文摘瞄准:在一个动物模型在不含酒精的脂肝疾病(NAFLD ) 的预防每氧化和口头的 SNAC 管理的效果在类脂化合物的抑制评估 S-nitroso-N-acetylcysteine (SNAC ) 的潜力。方法:NAFLD 被胆碱缺乏的饮食为 4 wk 在 Wistar 雄的老鼠导致。对待 SNAC 的动物(n=6 )(1.4 mg/kg 每 SNAC 的天,口头上地) 与 2 个控制组相比:(n=6 ) 收到了 PBS 答案,其它(n=6 ) 收到了 NAC 答案(7 mg/kg 每天) 。组织学的变量半关于宏和 microvacuolar 脂肪被测定变化,它的带的分发,坏死的 foci,门和 perivenular 纤维变性,并且煽动性与带的分发渗入。从肝 homogenates 的样品的 LOOH 被 HPLC 确定。在门静脉的血浆的硝酸盐层次被化合光估计。水的低密度的脂蛋白(LDL ) 暂停(200 microg protein/mL ) 在 37 度摄氏为 15 h 在 SNAC (300 micromol/L ) 的缺席和存在与 CuCl (2 )(300 micromol/L ) 被孵化。LDL 氧化的程度被 fluorimetry 估计。亚油酸(LA )(18.8 micromol/L ) 氧化被大豆 lipoxygenase (SLO )(0.056 micromol/L ) 当面在 37 度摄氏导致并且 N-acetylcysteine (NAC ) 和 SNAC (56 和 560 micromol/L ) 的缺席并且在 234 点监视了 nm。结果:在控制组的动物在仙子门区域开发了中等的宏和微小囊的丰满的变化。对待 SNAC 的动物与丰满的变化的缺席显示了仅仅分离的组织学的改变并且没得肝脂肪变性。在对待 SNAC 的组的 NAFLD 的缺席断然在肝匀浆在 LOOH 的集中与减少被相关,与控制组相比(0.7+/-0.2 nmol/mg 对 3.2+/-0.4 nmol/mg 蛋白质,分别地 P<0.05 ) ,当 aminotransferases 的浆液层次是未改变的时。在每氧化阻止类脂化合物的 SNAC 的能力作为模型底层用 LA 和 LDL 在在试管内实验被证实。结论:SNAC 的口服在用胆碱缺乏的饮食喂的 Wistar 老鼠阻止 NAFLD 的发作。这效果与 SNAC 的能力被相关每氧化在试管内和在试管内堵住类脂化合物的繁殖。 | Claudia PMS de Oliveira Fernanda I Simplicio Vicencia MR de Lima Katia Yuahasi Fabio P Lopasso Venancio AF Alves Dulcinéia SP Abdalla Flair J Carrilho Francisco RM Laurindo Marcelo G de Oliveira | 2006 | World Journal of Gastroenterology2006，12，12： | 1 |
| 16 | Surveillance of antimicrobial susceptibility of Pseudomonas aeruginosa clinical isolates from a central hospital in Portuga显示文摘 | Cardoso O Alves AF Leitao R | 2007 | J Antimicrob Agents2007，60，2： | 1 |
| 17 | A meta-analysis of seriousadverse events reported with exenatide and liraglutide: acute pancreatitisand cancer显示文摘 | Alves C Batel-Marques F Macedo AF | 2012 | Diabetes Research and Clinical Practice2012，98，2： | 1 |
| 18 | A meta-analysis of serious adverse events reported with exenatide and liraglutide:acute pancreatitis and cancer显示文摘 | Alves C Batel-Marques F Macedo AF | 2012 | Diabetes Res Clin Pract2012，98，2： | 1 |
| 19 | Local delivery of EGF- liposome mediated bone modeling in orthodontic tooth movement by increasing RANKL expression 显示文摘 | Alves JB Ferreira CL Martins AF | 2009 | Life Sci2009，85，1920： | 1 |
| 20 | A meta-analysis of serious adverse events reported with exenatide and liraglutide: acute pancreatitis and cancer 显示文摘 | Alves C Batel-Marques F Macedo AF | 2012 | Diabetes Res Clin Pract2012，98，2： | 1 |
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