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| 1 | Inflammatory bowel disease:Therapeutic limitations and prospective of the stem cell therapy显示文摘Inflammatory bowel disease(IBD),consisting primarily of ulcerative colitis and Crohn’s disease,is a group of debilitating auto-immune disorders,which also increases the risk of colitis-associated cancer.However,due to the chronic nature of the disease and inconsistent treatment outcomes of current anti-IBD drugs(e.g.,approximately 30%non-responders to anti-TNFαagents),and related serious side effects,about half of all IBD patients(in millions)turn to alternative treatment options.In this regard,mucosal healing is gaining acceptance as a measure of disease activity in IBD patients as recent studies have correlated the success of mucosal healing with improved prognosis.However,despite the increasing clinical realization of the significance of the concept of mucosal healing,its regulation and means of therapeutic targeting remain largely unclear.Here,stemcell therapy,which uses hematopoietic stem cells or mesenchymal stem cells,remains a promising option.Stem cells are the pluripotent cells with ability to differentiate into the epithelial and/or immune-modulatory cells.The overreaching concept is that the stem cells can migrate to the damaged areas of the intestine to provide curative help in the mucosal healing process.Moreover,by differentiating into the mature intestinal epithelial cells,the stem cells also help in restoring the barrier integrity of the intestinal lining and hence prevent the immunomodulatory induction,the root cause of the IBD.In this article,we elaborate upon the current status of the clinical management of IBD and potential role of the stem cell therapy in improving IBD therapy and patient’s quality of life. | Rangnath Mishra Punita Dhawan Anand S Srivastava Amar B Singh | 2020 | World Journal of Stem Cells2020，12，10： | 4 |
| 2 | Significance of platelet count in children admitted with bronchiolitis显示文摘AIM To determine the true prevalence of thrombocytosis in children less than 2 years of age with bronchiolitis,its association with risk factors,disease severity and thromboembolic complications.METHODS A retrospective observational medical chart review of 305 infants aged two years or less hospitalized for bronchiolitis.Clinical outcomes included disease severity,duration of hospital stay,admission to pediatric intensive care unit,or death.They also included complications of thrombocytosis,including thromboembolic complications such as cerebrovascular accident,acute coronary syndrome,deep venous thrombosis,pulmonary embolus,mesenteric thrombosis and arterial thrombosis and also hemorrhagic complications such as bleeding(spontaneous hemorrhage in the skin,mucous membranes,gastrointestinal,respiratory,or genitourinary tracts).RESULTS The median age was 4.7 mo and 179 were males(59%).Respiratory syncytial virus was isolated in 268(84%),adenovirus in 23(7%) and influenza virus A or B in 13(4%).Thrombocytosis(platelet count > 500 × 109/L) occurred in 88(29%;95%CI:24%-34%),more commonly in younger infants with the platelet count declining with age.There was no significant association with the duration of illness,temperature on admission,white blood cell count,serum C-reactive protein concentration,length of hospital stay or admission to the intensive care unit.No death,thrombotic or hemorrhagic events occurred.CONCLUSION Thrombocytosis is common in children under two years of age admitted with bronchiolitis.It is not associated with disease severity or thromboembolic complications. | Amar Al Shibli Najla Alkuwaiti May Hamie Dima Abukhater Muhammad B Noureddin Abdulla Amri Salwa Al Kaabi Aysha Al Kaabi Mariam Harbi Hassib Narchi | 2017 | World Journal of Clinical Pediatrics2017，6，2： | 3 |
| 3 | FGF23 induces left ventricular hypertrophy显示文摘 | Faul C Amaral AP Oskouei B | 2011 | J Clin Invest2011，121，11： | 1 |
| 4 | A SYBR green real-time PCR assay to detect and quantify pork meat in processed poultry meat products显示文摘 | SOARES S AMARAL J S OLIVEIRA M B P P | 2013 | Meat Science2013，94，： | 1 |
| 5 | Development and verification of a one-dimensional ablation code including pyrolysis gas flow 显示文摘 | Amar A J Blackwell B F Edwards J R | 2009 | Journal of Thermophysics and Heat Transfer2009，23，1： | 1 |
| 6 | C-reactive protein elevation predicts pulse pressure reduction in hypertensive subjects 显示文摘 | Amar J Ruidavets J B Peyfieux J C | 2005 | Hypertension2005，46，1： | 1 |
| 7 | Lecithin: cholesterol acyltrans- ferase-from biochemistry to role in cardiovascular disease 显示文摘 | Rousset X Vaisman B Amar M | 2009 | Curr Opin Endocrinol Diabetes Obes2009，16，2： | 1 |
| 8 | Lipase and protease extraction from activated sludge 显示文摘 | Gessesse Amare Dueholm Thomas Petersen Steffen B | 2003 | Water Res2003，37，15： | 1 |
| 9 | Mucosal healing and inflammatory bowel disease:Therapeutic implications and new targets显示文摘Mucosal healing(MH)is vital in maintaining homeostasis within the gut and protecting against injury and infections.Multiple factors and signaling pathways contribute in a dynamic and coordinated manner to maintain intestinal homeostasis and mucosal regeneration/repair.However,when intestinal homeostasis becomes chronically disturbed and an inflammatory immune response is constitutively active due to impairment of the intestinal epithelial barrier autoimmune disease results,particularly inflammatory bowel disease(IBD).Many proteins and signaling pathways become dysregulated or impaired during these pathological conditions,with the mechanisms of regulation just beginning to be understood.Consequently,there remains a relative lack of broadly effective therapeutics that can restore MH due to the complexity of both the disease and healing processes,so tissue damage in the gastrointestinal tract of patients,even those in clinical remission,persists.With increased understanding of the molecular mechanisms of IBD and MH,tissue damage from autoimmune disease may in the future be ameliorated by developing therapeutics that enhance the body’s own healing response.In this review,we introduce the concept of mucosal healing and its relevance in IBD as well as discuss the mechanisms of IBD and potential strategies for altering these processes and inducing MH. | Megan Lynn Otte Raju Lama Tamang Julia Papapanagiotou Rizwan Ahmad Punita Dhawan Amar B Singh | 2023 | World Journal of Gastroenterology2023，29，7： | 1 |
| 10 | Numerical analysis of adsorptive temperature wave regenerative heat pump显示文摘 | Amar N B Sun L M Meunier F | 1996 | Applied Thermal Engineering1996，16，5： | 1 |
| 11 | Early pregnancy assessment in multiple pregnancies 显示文摘 | Francesco DA Amar B | 2014 | Best Prac Res Clin Obst Gynaecol2014，28，2： | 1 |
| 12 | Antimicrobial ellagitannin of punica granatumfruits显示文摘 | MACHADO T B LEAL I C AMARAL A C | 2002 | J Braz Chem Soc2002，13，5： | 1 |
| 13 | Serum albumin level and risk for mortality and hospitalization in adolescents on hemodialysis显示文摘 | Amaral S Hwang W Fivush B | | 0，，： | 1 |
| 14 | Adherence to highly active antiretroviral therapy and itS correlateS among HIV infected pediatric patientS in Ethiopia显示文摘 | Sibhatu B Amare D Alemayehu A | 2008 | BMC PediatricS2008，8，： | 1 |
| 15 | 显示文摘 | Amar MJ Vaisman BL Paigent B | 1997 | Circulation1997，96，： | 1 |
| 16 | Metabolic endotoxemia initiates obesity and insulin resistance 显示文摘 | Cani PD Amar J Iglesias MA Poggi M Knauf C Bastelica D Neyrinck AM Fava F Tuohy KM Chabo C Waget A Delm6e E Cousin B Sulpice T Chamontin B Ferrieres J Tanti JF Gibson OR Casteilla L Delzenne NM Alessi MC Burcelin R | 2007 | Diabetes2007，56，7： | 1 |
| 17 | FGF23 induces left ventricular hypertrophy显示文摘 | Faul C Amaral AP Oskouei B | | 0，，： | 1 |
| 18 | Development and verification of a one-dimensional ablation code including py- rolysis gas flow 显示文摘 | Amar A J Blackwell B F Edwards J R | 2009 | Journal of Thermophysics and Heat Transfer2009，23，1： | 1 |
| 19 | One-dimensional ablation using a full Newton’s method and finite control volume procedure显示文摘 | AMAR A J BLACKWELL B F EDWARDS J R | 2008 | Journal of Thermophysics and Heat transfer2008，22，1： | 1 |
| 20 | Time frequency and wavelet transform applied to selected problems in ultrasonic NDE显示文摘 | Redouane D Mohamed K Amar B | | 0，，8： | 1 |
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