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| 1 | Doxycycline blocks gastric ulcer by regulating matrix metalloproteinase-2 activity and oxidative stress显示文摘AIM: To examine the effect of doxycycline on the activity of matrix metalloproteinases (MMPs) and oxidative stress in gastric tissues of rats following gastric injury.METHODS: Gastric ulcers were generated in rats by administration of 70% ethanol,and activity of doxycycline was tested by administration 30 min prior to ethanol.Similarly,the effect of doxycycline was tested in an indomethacin-induced gastric ulcer model.The activities and expression of MMPs were examined by zymography and Western blot analysis.RESULTS: Gastric injury in rats as judged by elevated ulcer indices following exposure to ulcerogen,either indomethacin or ethanol,was reversed significantly by doxycycline.Indomethacin-induced ulcerated gastric tissues exhibited about 12-fold higher proMMP-9 activity and about 5-fold higher proMMP-3 activity as compared to control tissues.Similarly,ethanol induced about 22-fold and about 6-fold higher proMMP-9 and proMMP-3 activities,respectively,in rat gastric tissues.Both proMMP-9 and MMP-3 activities were markedly decreased by doxycycline in ulcerogen treated rat gastric tissues.In contrast,the reduced MMP-2 activity in ulcerated tissues was increased by doxycycline during ulcer prevention.On the other hand,doxycycline inhibited significantly proMMP-9,-2 and -3 activities in vitro.In addition,doxycycline reduced oxidative load in gastric tissues and scavenged H2O2 in vitro.Our results suggest a novel regulatory role of doxycycline on MMP-2 activity in addition to inhibitory action on MMP-9 and MMP-3 during prevention of gastric ulcers.CONCLUSION: This is the first demonstration of dual action of doxycycline,that is,regulation of MMP activity and reduction of oxidative stress in arresting gastric injury. | Laishram Pradeepkumar Singh Amartya Mishra Debjit Saha Snehasikta Swarnakar | 2011 | World Journal of Gastroenterology2011，17，28： | 5 |
| 2 | Poverty: An ordinal approach to measurement显示文摘 | AMARTYA K | 1976 | Econometrica1976，44，2： | 1 |
| 3 | Rationality and Social Choice 显示文摘 | Amartya Sen | 1995 | A- merlcan Economic Review1995，，03： | 1 |
| 4 | Real National Income显示文摘 | Amartya Sen | 1976 | The Review of Economic Studies1976，43，1： | 1 |
| 5 | Democracy and its Global Roots显示文摘 | Amartya Sen | 2003 | The New Republic2003，，14： | 1 |
| 6 | Guideline for Projects Evaluation显示文摘 | Partha Dasgupta and Amartya Sen | 1972 | United Nations Industrial Development Organization Vienna1972，187，3： | 1 |
| 7 | How to Judge Globalism显示文摘 | Sen Amartya | 2002 | The American Prospect2002，13，1： | 1 |
| 8 | Nanocrystalline silicon: A material for thin film solar cells with better stability 显示文摘 | Mukhopadhyay Sumita Chowdhury Amartya Ray Swati | 2008 | Thin Solid Film2008，516，20： | 1 |
| 9 | Issues in the Measurement of Poverty 显示文摘 | SEN AMARTYA | 1979 | The Scandinavian Journal of Economics Measurement in Public Choice1979，，81： | 1 |
| 10 | Development as Capabilities Expansion 显示文摘 | Amartya Sen | 1989 | Journal of Development Planning1989，19，： | 1 |
| 11 | Informational Bases of Alternative Welfare Approaches:Aggregation and Income Distribution显示文摘 | AMARTYA S | 1974 | Public Economics1974，31，2： | 1 |
| 12 | Will there be any hope? 显示文摘 | AMARTYA S | 2000 | Time2000，，22： | 1 |
| 13 | A Possibility Ttheory on Majority Decisions显示文摘 | Amartya Sen | 1966 | Econometrica1966，，2： | 1 |
| 14 | IngredientsofFamine Analysis Availability andEntitlements显示文摘 | Sen Amartya | | 0，，： | 1 |
| 15 | Informational Bases of Alternative Welfare Approaches: Aggregation and Income Distribution显示文摘 | AMARTYA S | 1974 | Joumal of Public Economics1974，31，2： | 1 |
| 16 | An Ordinal Approach to Measurement显示文摘 | Sen Amartya K. Poverty | | 0，，： | 1 |
| 17 | A sociological Approach to the Measurement of Poverty: A Reply to Professor Peter Townsend显示文摘 | Amartya Sen | 1985 | Oxford Economic Papers1985，，12： | 1 |
| 18 | Personal Utilities and Public Judgments:Or What's Wrong With Welfare Economics? 显示文摘 | SEN Amartya K | 1979 | Economic Journal1979，89，： | 1 |
| 19 | Well-Being,Agency and Freedom显示文摘 | Amartya Sen | 1985 | The Journal of Philosophy1985，，4： | 1 |
| 20 | The Nature and Classes of Prescriptive Judg- ment 显示文摘 | Sen Amartya | 1967 | Philosophical Quarterly1967，17，66： | 1 |
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