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| 1 | Statistical design and evaluation of a propranolol HCl gastric floating tablet显示文摘The purpose of this research was to apply statistical design for the preparation of a gastric floating tablet(GFT)of propranolol HCl and to investigate the effect of formulation variables on drug release and the buoyancy properties of the delivery system.The contents of polyethylene oxide(PEO)WSR coagulant and sodium bicarbonate were used as independent variables in central composite design of the best formulation.Main effects and interaction terms of the formulation variables were evaluated quantitatively using a mathematical model approach showing that both independent variables have significant effects on floating lag time,%drug release at 1 h(D_(1h))and time required to release 90%of the drug(t_(90)).The desired function was used to optimize the response variables,each with a different target,and the observed responses were in good agreement with the experimental values.FTIR and DSC studies of the statistically optimized formulation revealed there was no chemical interaction between drug and polymer.The statistically optimized formulation released drug according to first order kinetics with a non-Fickian diffusion mechanism.Evaluation of the optimized formulation in vivo in human volunteers showed that the GFT was buoyant in gastric fluid and that its gastric residence time was enhanced in the fed but not the fasted state. | Meka Venkata Srikanth Nali Sreenivasa Rao Songa Ambedkar Sunil Battu Janaki Ram Venkata Ramana Murthy Kolapalli | 2012 | Acta Pharmaceutica Sinica B2012，2，1： | 6 |
| 2 | Colonic adenocarcinoma,mucosa associated lymphoid tissue lymphoma and tuberculosis in a segment of colon:A case report显示文摘Synchronous occurrence of adenocarcinoma and mucosa associated lymphoid tissue(MALT) lymphoma of colon is rare,and its presence with coexisting tuberculosis is still rarer.To our knowledge,this may be the first case report.In the present report,we describe a 43-year-old female who presented with a history of abdominal pain,fever,loss of weight and loss of appetite.Colonoscopy showed a large ulceroproliferative mass arising from the caecum,biopsy of which showed it to be adenocarcinoma of the colon.A right hemicolectomy was performed and microscopic study of the colon revealed tuberculosis and synchronous adenocarcinoma with lymphoma.Eight of sixteen lymph nodes showed tuberculosis and three of sixteenpericoloniclymphnodes showed metastatic deposits.Immunostains further confirmed the tumour to be adenocarcinoma with MALT lymphoma.We would like to highlight the diagnostic challenges arising from the multi-faceted presentations of these three conditions. | Ambedkar Raj Kulandai Velu Banushree C Srinivasamurthy Krishnan Nagarajan Ilavarasi Sinduja | 2014 | World Journal of Gastrointestinal Oncology2014，6，9： | 3 |
| 3 | Nailing versus plating in hu- merus shaft fractures: a prospective comparative study 显示文摘 | Singisetti K Ambedkar M | 2010 | Int Orthop2010，34，4： | 1 |
| 4 | Nailing versus plating humerus shaft fractures:A prospective comparative study显示文摘 | Sing qisett i K Ambedkar M | 2010 | Int Orthop2010，34，4： | 1 |
| 5 | Development of predictive model for fly-ash erosion phe- nomena in coal-burning boilers 显示文摘 | NAGARAJAN R AMBEDKAR B GOWRISANKAR S | 2009 | Wear2009，，267： | 1 |
| 6 | Nailing versus platinghumerus shaft fractures:A prospective comparativestudy显示文摘 | Singqisetti K Ambedkar M | 2010 | Int Orthop2010，34，4： | 1 |
| 7 | Nailing versus plating hu- merus shaft fractures: a prospective comparative study 显示文摘 | Singqisetti K Ambedkar M | 2010 | Int Orthop2010，34，4： | 1 |
| 8 | Nailing versus plating in humerus shaft fractures : a prospective comparative study显示文摘 | Singisetti K Ambedkar M | 2010 | Int Orthop2010，34，4： | 1 |
| 9 | Development of predictive model for fly-ash erosion phenomena in coal-burning boilers显示文摘 | Nagarajan R Ambedkar B Gowrisankar S | 2009 | Wear2009，267，1： | 1 |
| 10 | Nailing versus plating in humerus shaft fractures: a pro- spective comparative study 显示文摘 | Singisetti K Ambedkar M | 2010 | Int Or- thop2010，34，4： | 1 |
| 11 | Nailing versus plating in humerus shaft fractures:a prospective comparative study显示文摘 | Singisetti K Ambedkar M | | 0，，04： | 1 |
| 12 | Nailing versus plating in humerus shaft fractures: a prospective comparative study显示文摘 | Singisetti K Ambedkar M | 2010 | Int Orthop2010，34，4： | 1 |
| 13 | Nailing versus plating in humerus shaft fractures: a prospective comparative study 显示文摘 | Singisetti K Ambedkar M | 2010 | Int Oahop2010，34，4： | 1 |
| 14 | An Algebraic Implicitization and Specialization of Minimum KL-Divergence Models显示文摘 | Ambedkar D Joel G M | 2010 | 2010，，： | 1 |
| 15 | Nailing versus plating in humerus shaft fractures:a prospective comparative study显示文摘 | Singisetti K Ambedkar M | 2010 | Int Orthop2010，34，4： | 1 |
| 16 | Ultrasonic coal-wash for de-sulfurization显示文摘 | Ambedkar B Nagarajan R Jayanti S | 2011 | Ultrasonics Sonochemistry2011，18，3： | 1 |
| 17 | Biologically Active Secondary Metabolites from Streptomyces显示文摘 | DESHPANDE B S AMBEDKAR S S SHEWALE J G | 1988 | Enzyme and Microbial Technology1988，10，8： | 1 |
| 18 | Nailing versus plating in humerus shaft fractures:a prospective comparative study显示文摘 | Singisetti K Ambedkar M | 2010 | Int Orthop2010，34，4： | 1 |
| 19 | Investigation of high-frequency, high-intensity ultrasonic for size reduction and washing of coal in aqueous medium 显示文摘 | AMBEDKAR B NAGARAJAN R JAYANTI S | 2011 | Industrial and Engineering Chemistry Research2011，50，13： | 1 |
| 20 | Investigation of high-fre- quency, high-intensity ultrasonics for size reduction and washing of coal in aqueous medium显示文摘 | Ambedkar B Nagarajan R Jayanti S | 2011 | Industrial Engineering Chemis- try Research2011，50，13： | 1 |
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