|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Optimization of high-speed railway pantographs for improving pantograph-catenary contact显示文摘A crucial system for the operation of high-speed trains is the pantograph catenary interface as it is the sole responsible to deliver electrical power to the train. Being the catenary a stationary system with a long lifespan it is also less likely to be redesigned and upgraded than the pantographs that fit the train vehicles. This letter proposes an optimization procedure for the improvement of the contact quality between the pantograph and the catenary solely based on the redesign of the pantograph head suspension characteristics. A pantograph model is defined and validated against experimental dynamic characteristics of existing pantographs. An optimization strategy based on the use of a global optimization method, to find the vicinity of the optimal solution, followed by the use of a deterministic optimization algorithm, to fine tune the optimal solution, is applied here. The spring stiffness, damping characteristics and bow mass are the design variables used for the pantograph optimization. The objective of the optimal problem is the minimization of the standard deviation of the contact force history, which is the most important quantity to define the contact quality. The pantograph head suspension characteristics are allowed to vary within technological realistic limits. It is found that current high-speed railway pantographs have a limited potential for mechanical improvements, not exceeding 10%-15% on the decrease of the standard deviation of the contact force. | Jorge Ambrósio Joo Pombo Manuel Pereira | 2013 | Theoretical & Applied Mechanics Letters2013，3，1： | 15 |
| 2 | Oral pharmacological treatment for patent ductus arteriosus in premature neonates with hemodynamic repercussions显示文摘Objective: To evaluate the efficacy of oral indomethacin, ibuprofen, and paracetamol in oral dosage form on patent ductus arteriosus(PDA) in premature neonates with significant clinical and hemodynamic repercussions(CHRs) and to determine the effect of these respective treatments on renal function.Methods: A retrospective study of cases of PDA in premature neonates in the Neonatal Intensive Care Unit was conducted. The treatments consisted of indomethacin[0.2 mg/(kg$d), 3-day cycle], ibuprofen [10 mg/(kg$d) followed by 5 mg/(kg$d), 3-day cycle], and paracetamol(15 mg/kg every 6 h, 5-day cycle). The drugs were administered as an oral solution. The following variables were considered: gestational age,newborn weight at birth, Apgar score, diuresis, serum creatinine and urea levels, and serum electrolyte levels(sodium and potassium).Results: Treatment with indomethacin presented efficacy of 87.5% in closure of the ductus with a mean outcome period of 3.5 d. In premature neonates with CHRs and contraindications for indomethacin, the initial treatment with either ibuprofen or paracetamol failed to close the ductus. However, when this treatment was followed by indomethacin, closure occurred in 66.7% of the neonates, with an outcome period of9.66 d. The initial treatment with one cycle of ibuprofen followed by one or two cycles of paracetamol failed to close the ductus.Conclusions: Oral indomethacin was effective for closure of the PDA in premature neonates with severe CHRs. Oral paracetamol or ibuprofen for PDA closure in premature neonates with severe CHRs and contraindications for indomethacin was ineffective.However, results in clinical improvements of neonates allowed the subsequent use of indomethacin and successful closure of the ductus. A significant reduction of diuresis occurred in neonates who were treated with indomethacin, either as a first-line treatment or after the failure of ibuprofen or paracetamol. | Clarissa de Albuquerque Botura Bruno Ambrósio da Rocha Thiely Balensiefer Franciele Queiroz Ames Ciomar Aparecida Bersani-Amado Roberto Kenji Nakamura Cuman | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，11： | 4 |
| 3 | Plant adaptation to low phosphorus availability:Core signaling,crosstalks,and applied implications显示文摘Phosphorus(P)is an essential nutrient for plant growth and reproduction.Plants preferentially absorb P as orthophosphate(Pi),an ion that displays low solubility and that is readily fixed in the soil,making P limita-tion a condition common to many soils and Pi fertilization an inefficient practice.To cope with Pi limitation,plants have evolved a series of developmental and physiological responses,collectively known as the Pi starvation rescue system(PSR),aimed to improve Pi acquisition and use efficiency(PUE)and protect from Pi-starvation-induced stress.Intensive research has been carried out during the last 20 years to un-ravel the mechanisms underlying the control of the PSR in plants.Here we review the results of this research effort that have led to the identification and characterization of several core Pi starvation signaling components,including sensors,transcription factors,microRNAs(miRNAs)and miRNA inhibitors,kinases,phosphatases,and components of the proteostasis machinery.We also refer to recent results revealing the existence of intricate signaling interplays between Pi and other nutrients and antagonists,N,Fe,Zn,and As,that have changed the initial single-nutrient-centric view to a more integrated view of nutrient homeostasis.Finally,we discuss advances toward improving PUE and future research priorities. | Javier Paz-Ares Maria Isabel Puga Monica Rojas-Triana Iris Martinez-Hevia Sergio Diaz Cesar Poza-Carrión Miguel Mi(n)ambres Antonio Leyva | 2022 | Molecular Plant2022，15，1： | 2 |
| 4 | A real-time RT-PCR assay for detection and absolute quantitation of Citrus tristeza virus in different plant tissues显示文摘 | Susana Ruiz-Ruiz Pedro Moreno José Guerri Silvia Ambrós | 2007 | Journal of Virological Methods2007，，2： | 2 |
| 5 | Both physical fitness and acute exercise regulate nitric oxide formation in healthy humans 显示文摘 | Jungersten L Ambring A Wall B | 1997 | J Appl Physiol1997，82，3： | 1 |
| 6 | Early keratocyte apoptosis after epithelial scrape injury in the human cornea显示文摘 | Renato Ambrósio Newton Kara-José Steven E. Wilson | 2009 | Experimental Eye Research2009，，4： | 1 |
| 7 | Assessment of a large watershed in Brazil using emergy evaluation and geographical information system 显示文摘 | Agostinho F Ambrs L A Ortega E | 2010 | Ecological Modelling2010，221，8： | 1 |
| 8 | Induction of apop tosis and inhibiti on of cell p roliferati on by survivin gene targeting显示文摘 | Ambr osiniG AdidaC SirugoG | 1998 | Jbiol Chem1998，273，11： | 1 |
| 9 | Medterm results of the edge-to-edge technique for complex mitra valve repair显示文摘 | BRINSTER D R UNIC D D'AMBR A | 2006 | Ann Thorac Surg2006，81，： | 1 |
| 10 | Opioid rotation in patients initiated on oxycodone or morphine:a register study显示文摘 | Ericson L Ambring A Bjrholt I | 2013 | J Pain Res2013，6，： | 1 |
| 11 | Selenium and Tellurium Systematics of the Earth's Mantle from High Precision Analyses of Ultra-Depleted Orogenic Peridotites显示文摘 | Stephan K Ambre L Jean P L | 2012 | Geochimical et Cosmochimica Acta2012，86，： | 1 |
| 12 | LASIK-associated dry eye and neurotrophic epitheliopathy:pathophysiology and strategies for prevention and treatment显示文摘 | Ambrósio R Jr Tervo T Wilson SE | 2008 | J Refract Surg2008，24，4： | 1 |
| 13 | Both physical fitness and acute exercise regulate nitric oxide formation in healthy humans显示文摘 | Jungersten L Ambring A Wall B | 1997 | J Appl Physiol1997，82，3： | 1 |
| 14 | Early keratocyte apoptosis after epithelial scrape injury in the human cornea显示文摘 | Ambrósio R Jr Kara-José N Wilson S E | | 0，，04： | 1 |
| 15 | Epidemiology of surgically managed pelvic organ prolapse and urinary incontinence显示文摘 | Ambre L. Olsen Virginia J. Smith John O. Bergstrom Joyce C. Colling Amanda L. Clark | 1997 | Obstetrics & Gynecology1997，，4： | 1 |
| 16 | Complex flexible multibody systems with application to vehicle dynamics显示文摘 | Ambrósio J C Gonoalves J C | | 0，，02： | 1 |
| 17 | Condition factor in nine species of fish of the Characidae family in the upper Paraná river floodplain,Brazil显示文摘 | LIZAMA M AMBR(O)SIO A M | | 0，，1： | 1 |
| 18 | Vitamin D concentrations in familial combined hyperlipidemia:effects of lipid lowering treatment显示文摘 | Miambres I Snchez-Quesada JL Snhez-Hernndez J | 2014 | Diabetol Metab Syndr2014，6，1： | 1 |
| 19 | Optimization of vehicle suspension systems for improved comfort of road vehicles using flexible multibody dynamics显示文摘 | Gon?alves J C Ambrósio J C | | 0，，1： | 1 |
| 20 | Wound healing in the cornea: a review of refractive surgery complications and new prospects for therapy显示文摘 | Netto MV Mohan RR Ambr 6 sio R Jr | 2005 | Cornea2005，24，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员