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| 1 | WJH 6^(th) Anniversary Special Issues(4): Cirrhosis Role of vaptans in the management of hydroelectrolytic imbalance in liver cirrhosis显示文摘Ascites and hyponatremia are the most common complications in patients with liver cirrhosis and develop as a consequence of a severe impairment of liver function and portal hypertension. Increasing evidences support the central role of renal function alterations in the pathogenesis of hydroelectrolytic imbalances in cirrhotic patients, thus implying a dense cross-talk between liver and kidney in the systemic and splanchnic vascular homeostasis in such subjects. Since Arginin Vasopressin(AVP) hyperincretion occurs at late stage of cirrhosis and plays an important role in the development of refractory ascites, dilutional hyponatremia and finally hepato-renal syndrome, selective antagonists of AVP receptors V2(vaptans) have been recently introduced in the therapeutic algorithm of advanced cirrhotic patients. Despite the promising results of earlier phasetwo studies, randomized controlled trials failed to find significant results in terms of efficacy of such drugs both in refractory ascites and hyponatremia. Moreover, concerns on their safety profile arise, due to the number of potentially severe side effects of vaptans in the clinical setting, such as hypernatremia, dehydration, renal impairment, and osmotic demyelination syndrome. More robust data from randomized controlled trials are needed in order to confirm the potential role of vaptans in the management of advanced cirrhotic patients. | Antonio Facciorusso Annabianca Amoruso Viviana Neve Matteo Antonino Valentina Del Prete Michele Barone | 2014 | World Journal of Hepatology2014，6，11： | 4 |
| 2 | 肠道子宫内膜异位症诊断和治疗的新观点显示文摘子宫内膜异位症是一种主要影响育龄妇女的慢性疾病。部分肠道子宫内膜异位症患者可能是无症状的,除了不孕之外,有部分患者表现为各种各样的症状,如排便习惯改变(便秘或腹泻)、排便困难、痛经和性交痛等。迄今为止,对于疑似有肠道受累的子宫内膜异位症患者,尚无明确的评估指南。目前的检查手段包括经阴道或经直肠超声检查、核磁共振成像和气钡双重对比造影。不同的检查方法可提供更多的信息,包括是否存在病灶、病灶的位置和累及的范围等,确保患者充分了解病情,同时也可对术前计划进行优化。如需手术治疗,应由经验丰富的医生在有多学科护理条件的中心进行手术。治疗应根据患者的症状和意愿进行调整,目的是尽可能切除所有病灶的同时保留器官的功能。本综述将讨论肠道子宫内膜异位症诊断和处理的最新观点。 | 梁炎春 韦雅婧 杨如玉 姚书忠(译/审校) Nassir Habib Gabriele Centini Lucia Lazzeri Nicola Amoruso Lionel El Khoury Errico Zupi Karolina Afors | 2020 | 国际妇产科学杂志2020，47，6： | 3 |
| 3 | Evolution of nonspecific duodenal lymphocytosis over 2 years of follow-up显示文摘AIM: To assess the evolution of duodenal lymphocytosis(DL), a condition characterized by increased intraepithelial lymphocytes(IELs), over 2 years of follow-up.METHODS: Consecutive patients undergoing upper endoscopy/histology for abdominal pain, diarrhea, weight loss, weakness or other extraintestinal features compatible with celiac disease(CD) were included. Evaluation of IELs infiltrate in duodenal biopsy sampleswas carried out by CD3-immunohistochemistry and expressed as number of positive cells/100 enterocytes. Diagnostic agreement on the IELs count was tested by calculating the weighted k coefficient. All patients underwent serological detection of autoantibodies associated with CD: Ig G and Ig A anti-tissue transglutaminase and endomysium. Each patient underwent further investigations to clarify the origin of DL at baseline and/or in the course of 2 years of follow-up every six months. Autoimmune thyroiditis, intestinal infections, parasitic diseases, bacterial intestinal overgrowth, hypolactasia and wheat allergy were detected. Colonoscopy and enteric magnetic resonance i m a g i n g w e r e p e r f o r m e d w h e n n e c e s s a r y. R i s k factors affecting the final diagnosis were detected by multinomial logistic regression and expressed as OR.RESULTS: Eighty-five patients(16 males, 69 females, aged 34.1 ± 12.5 years) were followed up for a mean period of 21.7 ± 11.7 mo. At baseline, endoscopy/duodenal biopsy, CD3 immunohistochemistry revealed: > 25 IELs/100 enterocytes in 22 subjects, 15-25 IELs in 37 and < 15 IELs in 26. They all had negative serum anti-transglutaminase and anti-endomysium, whilst 5 showed Ig G anti-gliadin positivity. In the course of follow-up, 23 developed CD seropositivity and gluten sensitivity(GS) was identified in 19. Other diagnoses were: 5 Helicobacter pylori infections, 4 jejunal Crohn's disease, 1 lymphocytic colitis and 1 systemic sclerosis. The disease in the remaining 32 patients was classified as irritable bowel syndrome because of the lack of diagnostic evidence. At multivariate analysis, the evolution towards CD was associated with an IELs infiltrate > 25(OR = 1640.4) or 15-25(OR = 16.95), human leukocyte antigen(HLA) DQ2/8(OR = 140.85) or DQA1*0501(OR = 15.36), diarrhea(OR = 5.56) and weakness(OR = 11.57). GS was associated with IELs 15-25(OR = 28.59), autoimmune thyroiditis(OR = 87.63), folate deficiency(OR = 48.53) and diarrhea(OR = 54.87).CONCLUSION: DL may have a multifactorial origin but the IELs infiltrate and HLA are strong predictive factors for CD development and a clinical diagnosis of GS. | Giuseppe Losurdo Domenico Piscitelli Antonio Giangaspero Mariabeatrice Principi Francesca Buffelli Floriana Giorgio Lucia Montenegro Claudia Sorrentino Annacinzia Amoruso Enzo Ierardi Alfredo Di Leo | 2015 | World Journal of Gastroenterology2015，21，24： | 2 |
| 4 | Extra-intestinal manifestations of non-celiac gluten sensitivity: an expanding paradigm显示文摘Non celiac gluten sensitivity(NCGS) is a syndrome characterized by a cohort of symptoms related to the ingestion of gluten-containing food in subjects who are not affected by celiac disease(CD) or wheat allergy. The possibility of systemic manifestations in this condition has been suggested by some reports. In most cases they are characterized by vague symptoms such as ‘foggy mind', headache, fatigue, joint and muscle pain, leg or arm numbness even if more specific complaints have been described. NCGS has an immune-related background. Indeed there is a strong evidence that a selective activation of innate immunity may be the trigger for NCGS inflammatory response. The most commonly autoimmune disorders associated to NCGS are Hashimoto thyroiditis, dermatitis herpetiformis, psoriasis and rheumatologic diseases. The predominance of Hashimoto thyroiditis represents an interesting finding, since it has been indirectly confirmed by an Italian study, showing that autoimmune thyroid disease is a risk factor for the evolution towards NCGS in a group of patients with minimal duodenal inflammation. On these bases, an autoimmune stigma in NCGS is strongly supported; it could be a characteristic feature that could help the diagnosis and be simultaneously managed. A possible neurological involvement has been underlined by NCGS association with gluten ataxia, gluten neuropathy and gluten encephalopathy. NCGS patients may show even psychiatric diseases such as depression, anxiety and psychosis. Finally, a link with functional disorders(irritable bowel syndrome and fibromyalgia) is a topic under discussion. In conclusion, the novelty of this matter has generated an expansion of literature data with the unavoidable consequence that some reports are often based on low levels of evidence. Therefore, only studies performed on large samples with the inclusion of control groups will be able to clearly establish whether the large information from the literature regarding extra-intestinal NCGS manifestations could be supported by evidence-based agreements. | Giuseppe Losurdo Mariabeatrice Principi Andrea Iannone Annacinzia Amoruso Enzo Ierardi Alfredo Di Leo Michele Barone | 2018 | World Journal of Gastroenterology2018，24，14： | 2 |
| 5 | Femtosecond laser deposition of TiO_2 nanoparticleassembled films with embedded CdS nanoparticles显示文摘Based on the normal pulsed laser ablation method,femtosecond pulsed laser deposition(fs-PLD)is adopted in vacuum for the production of TiO2nanoparticle-assembled films.We study the morphology and electronic characteristics of TiO2nanoparticle-assembled films deposited at different oxygen background gas pressures from high vacuum(~10-4Pa)to 100 Pa and different deposition time.Our results show that TiO2nanoparticle-assembled films obtained in high vacuum present both a mixture with rutile phase and anatase phase and a pure rutile phase.At the same time,there are more mesoporous structures in the film after annealing,which is beneficial for the enhancement of photocatalytic activity.In water splitting experiment,part of the TiO2nanoparticle-assembled films embedded with a small mass fraction of CdS nanoparticles(~5%)present an interesting photocurrent enhancement with a maximum value of^0.2mA/cm2under a solar simulator. | 倪晓昌 桑丽霞 张洪杰 Anoop Kiliyanam-kandy Salvatore Amoruso 王宣 Rosalba Fittipaldi 李彤 胡明列 徐丽娟 | 2014 | Optoelectronics Letters2014，10，1： | 2 |
| 6 | Temporally and spectrally resolved analysis of a copper plasma plume produced by ultrafast laser ablation显示文摘 | Wang X Amoruso S Xia J | 2009 | Applied Surface Science2009，255，： | 1 |
| 7 | Long-term func- tional outcome and health status of patients with critical illness polyneuromyopathy显示文摘 | Intiso D Amoruso L Zarrelli M | 2011 | Acta Neurol Scand2011，123，3： | 1 |
| 8 | Macrophage-stimulating protein differently affects human alveolar macrophages from smoker and non-smoker patients:evaluation of respiratory burst,cytokine release and NF-kappaB pathway显示文摘 | Gunella G Bardelli C Amoruso A | | 0，，4： | 1 |
| 9 | Constraints on slow earthquake dynamics from a swarm in Central Italy显示文摘 | Crescentini L Amoruso A Scarpa R | 1999 | Science1999，286，： | 1 |
| 10 | Enhancement of rat and human phagocytesuperoxide anion radical production by cadmium in vitro显示文摘 | Amoruso MA Witz G Goldstein BD | 1982 | Toxicol Lett1982，10，2： | 1 |
| 11 | Thundercloud Pre-stroke Electrostatic Modeling 显示文摘 | AMORUSO V LATTARULO F | 2002 | Journal of Electrostatics2002，56，： | 1 |
| 12 | Role of estrogens and epidermal growth factor in hepatocellular carcinoma (HCC)显示文摘 | Francavilla A Panella C Amoruso A | 1991 | Dig Dis Sci1991，36，9： | 1 |
| 13 | Effects of substrate temperature on nanoparticle-assembled Fe films produced by ultrafast pulsed laser deposition显示文摘 | Ausanio G Iannotti V Amoruso S | 2012 | Applied Surface Science2012，15，： | 1 |
| 14 | Thundercloud pre-stroke electrostatic modeling显示文摘 | AMORUSO V LATTARULO F | 2002 | Journal of Electrostatics2002，56，2： | 1 |
| 15 | Acute pancreatic necrosis complicated by infection and gastro-intestinal translocation: pathogenesis correlation and therapeutic implication显示文摘 | Miniello S Testini M Amoruso M | 2002 | Ann Ital Chir2002，73，6： | 1 |
| 16 | Organization of brain networks governed by long-range connections index autistic traits in the general population显示文摘 | Barttfeld P Amoruso L Ais J | 2013 | J Neurodev Disord2013，5，1： | 1 |
| 17 | Cytokines release inhibition from activated monocytes,and reduction of in-stent neointimal growth in humans显示文摘 | Pesarini G Amoruso A Ferrero V | 2010 | Atherosclerosis2010，211，1： | 1 |
| 18 | Femtosecond laser pulse irradiation of solid targets as a general route to nanoparticle formation in a vacuum显示文摘 | Amoruso S Ausanio G Bruzzese R | 2005 | Physical Review B2005，71，03： | 1 |
| 19 | Halitosis and Helicobacter pylori:a possible relationship 显示文摘 | Ierardi E Amoruso A La Notre T | 1998 | Dig Dis Sci1998，43，12： | 1 |
| 20 | Intestinal permeability in patients with adverse reactions to food显示文摘 | M.T. Ventura L. Polimeno A.C. Amoruso F. Gatti E. Annoscia M. Marinaro E. Di Leo M.G. Matino R. Buquicchio S. Bonini A. Tursi A. Francavilla | 2006 | Digestive and Liver Disease2006，，10： | 1 |
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