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| 1 | In vitro total phenolics,flavonoids contents and antioxidant activity of essential oil,various organic extracts from the leaves of tropical medicinal plant Tetrastigma from Sabah显示文摘Objective:To detect the in vitro total phenolics,flavonoids contents and antioxidant activity of essential oil,various organic extracts from the leaves of tropical medicinal plant Tetrastigma from Sabah.Methods:The dry powder leaves of Tetrastigma were extracted with different organic solvent such as hexane.ethyl acetate,chloroform,butanol and aqueous methanol.The total phenolic and total flavonoids contents of the essential oil and various organic extracts such as hexane,ethyl acetate,chloroform,butanol and aqueous ethanol were determined by Folin-Ciocalteu method and the assayed antioxidant activity was determined in vitro models such as antioxidant capacity by radical scavenging activity usingα,α-diphenyl-β-picrylhydrazyl (DPPH) method.Results:The total phenolic contents of the essential oil and different extracts as gallic acid equivalents were found to be highest in methanol extract(386.22 mg/g) followed by ethyl acetate(190.89 mg/g).chloroform(175.89 mg/g).hexane(173.44 mg/g).and Imtanol extract (131.72 mg/g) and the phenolic contents not detected in essential oil.The antioxidant capacity of the essential oil and different extracts as ascorbic acid standard was in the order of methanol extract>ethyl acetate extract>chloroform>butanol>hexane extract also the antioxidant activity was not detected in essential oil.Conclusions:The findings show that the extent of antioxidant activity of the essential oil and all extracts are in accordance with the amount of phenolics present in that extract.Leaves of Tetrastigma being rich in phenolics may provide a good source of antioxidant. | M Amzad Hossain Muhammad Dawood Shah Charles Gnanaraj Muhammad Iqbal | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，9： | 9 |
| 2 | Gas chromatography-mass spectrometry analysis of different organic crude extracts from the local medicinal plant of Thymus vulgaris L显示文摘Objective:To isolate and analyze the chemical composition in different crude extracts of from the leaves of locally grown of Thymus vulgaris L(T.vulgaris)by gas chromatography-mass spectrometry(GC-MS).Methods:The shade dried leaves powder was extracted with methanol by using Soxhlet extractor.Methanol crude extracts of T.vulgaris and the derived fractions of hexane,chloroform,ethyl acetate and butanol were obtained.Results:Qualitative analyses of various organic crude extracts of T.vulgaris by using GC-MS showed that there were different types of high and low molecular weight compounds.Most of the isolated and identified compounds by GC-MS in the crude extracts are basically biologically important.Further,the T.vulgaris leaf possessed certain characteristics that can be ascribed to cultivation on a domestic plantation.The crude extracts were prepared from the powder leaves of T.vulgaris for respective compounds can be chosen on the basis of above GC-MS analysis.Conclusions:All the major compounds were identified and characterized by spectroscopic method in different organic crude extracts of T.vulgaris are biologically active molecules.Thus the identification of a good number of compounds in various crude extracts of T.vulgaris might have some ecological role. | Laila Salim Al Hashmi Mohammad Amzad Hossain Afaf Mohammed Weli Qasim Al-Riyami Jamal Nasser Al-Sabahi | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，1： | 4 |
| 3 | Chemical composition of essential oils and in vitro antioxidant activity of fresh and dry leaves crude extracts of medicinal plant of Lactuca Sativa L.native to sultanate of Oman显示文摘Objective:To isolate and analyse the chemical composition in the essential oils and free radical scavenging activity of different crude extracts from the fresh and dry leaves of vegetable plants of Lactuca sativa L.(L.sativa).Methods:The essential oils and volatile chemical constituents were isolated from the fresh and dry leaves of L.sativa(lettuce)grown in Sultanate of Oman by hydro distillation method.The antioxidant activity of the crude extracts was carried out by well established free radical scavenging activity(DPPH)method.Results:About 20 chemical compounds of different concentration representing 83.07%and 79.88%respectively were isolated and identified by gas chromatography-mass spectroscopy in the essential oils isolated from the fresh and dry leaves asα-pinene(5.11%and 4.05%).γ-cymene(2.07%and 1.92%),thymol(11.55%and 10.73%),durenol(52.00%and 49.79%),α-terpinene(1.66%and 1.34%),thymol acetate(0.99%and 0.67%),caryophyllene(2.11%and 1.98%),spathulenol(3.09%and 2.98%).camphene(4.11%and3.65%),limonene(1.28%and 1.11%)representing these major chemical compounds.However,some other minor chemical constituents were also isolated and identified from the essential oil of lettuce including p-pinene,α-terpinolene,linalool,4-terpineol,α-terpineol,o-methylthymol,L-alloaromadendrene and viridiflorene.Conclusions:The chemical consliluents in the essential oils from the locally grown lettuce were identified in the following classes or groups of chemical compounds such as monoterpenes,sesquiterpenes volatile organic compounds and their oxygenated hydrocarbons.Therefore,the essential oils and the crude extracts from Omani vegetable species of lettuce are active candidates which would be used as antioxidant,antifungal or antimicrobial agents in new drugs preparation for therapy of infectious diseases. | Rahma Said Salim Al Nomaani Mohammad Amzad Hossain Afaf Mohammed Weli Qasim Al-Riyami Jamal Nasser Al-Sabahi | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，5： | 3 |
| 4 | Characterization of antioxidant and antibacterial compounds from aerial parts of Haplophyllum tuberculatum显示文摘The aerial parts of Haplophyllum tuberculatum(H.tuberculatum)have traditionally been used by local communities to treat fever,gastrointestinal disorders,worms,malaria and fractures,how-ever,the responsible ingredients of the selected medicinal plant have not been identified.In the present study,antibacterial and antioxidant ingredients were isolated and characterized from the plant parts of locally grown H.tuberculatum,and their biological activity was evaluated.The powder aerial parts were extracted with methanol and the extract was successively frac-tionated with different polarities of solvents.All polarities of extracts(hexane,chloroform,ethyl acetate,butanol,methanol and water)were used to determine their antibacterial and antioxi-dant activity by established in-vitro method.The disk diffusion and free radical scavenging 2,2-diphenyl-1-picrylhydrazyl(DPPH)methods were used to evaluate antibacterial and antioxidant activities of the prepared extracts and pure isolated compounds at different concentrations against three strains of Gram-positive and three Gram-negative bacteria.The antibacterial activity results showed that all prepared fractions and isolated pure compounds of the plant species gave signif-icant activity against all Gram(+and-)bacterial strains with the range of inhibition 0-20 mm.The antioxidant activity of the prepared extracts at all concentrations also showed substantial activity.Based on the highest activity,ethyl acetate and chloroform extracts were selected for the separation and isolation of antioxidant and antibacterial compounds by thin layer chromatogra-phy(TLC),column chromatography(CC),and preparative thin layer chromatography(PTLIC).The structure of the isolated antioxidant and antibacterial compounds from the ethyl acetate and chloroform extracts were determined on the basis of nuclear magnetic resonance(NMR)and mass spectra.The isolated pure compounds and active extracts could be used as a medicine for various infectious related diseases. | Salma Salim Al-Saeghi Mohammad Amzad Hossain Salem Said Jaroof Al-Touby | 2022 | Journal of Bioresources and Bioproducts2022，7，1： | 2 |
| 5 | Study of total phenol,flavonoids contents and phytochemical screening of various leaves crude extracts of locally grown Thymus vulgaris显示文摘Objective:To prepare various crude extracts using different polarities of solvent and to quantitatively evaluate their total phenol,flavonoids contents and phytochemical screening of Thymus vulgaris collected from Al Jabal Al Akhdar,Nizwa.Sultanate of Oman.Methods:The leave sample was extracted with methanol and evaporated.Then it was defatted with water and extracted with different polarities organic solvents with increasing polarities.The prepare hexane,chloroform,ethyl acetate,hutanol and methanol crude extracts were used for their evaluation of total phenol,flavonoids contents and phytochemical screening study.The established conventional metliods were used for quantitative determination of total phenol,flavonoids contents and phytochemical screening.Results:Phytochemical screening for various crude extracts were tested and shown positive result for flavonoids,saponins and steroids compounds.The result for total phenol content was the highest in hutanol and the lowest in methanol crude extract whereas the total flavonoids contents was the highest in methanol and the lowest hexane crude extract.Conclusions:The crude extracts from locally grown Thymus vulgaris showed high concentration of flavonoids and it could be used as antibiotics for different curable and uncurable diseases. | Mohammad Amzad Hossain Khulood Ahmed Salim AL-Raqmi Zawan Hamood AL-Mijizy Afaf Mohammed Weli Qasim Al-Riyami | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，9： | 2 |
| 6 | Antimicrobial and cytotoxic potential of seeds and flowers crude extracts of sunflower显示文摘Oil-producing crops,including Helianthus annuus L.(H.annuus,Sunflower),have been used for the treatment of different human diseases since ancient times.This study aims to determine the antimicrobial and cytotoxic potential of different polarities of seeds and flower extracts of locally grown H.annuus by well-established bioassays.To achieve the objects,the plant extracts were prepared from both flowers and seeds powder samples individually with methanol solvent by using a Soxhlet extraction method.The antimicrobial and cytotoxic potential of the flowers and seed extracts were determined by the in vitro diffusion and brine shrimp method(BSL).The results of the antimicrobial potential of both prepared flower and seed extracts of various polarities at different concentrations showed promising potential against the gram-positive and gram-negative bacterial strains,within the range of inhibition zone 0–20 mm.Among the flower extracts,the highest potential was obtained in water extract and the lowest potential was in butanol extract followed by water>ethyl acetate>hexane>methanol>chloroform>butanol extracts.However,from the seed extracts,the highest potential was obtained in water extract and the lowest potential was in the methanol extract followed by water>hexane>butanol>ethyl acetate>chloroform>methanol extract.On the other hand,the results of cytotoxicity among the flowers extracts against the brine shrimp method where the highest LC50 against brine shrimp nauplii were found to be 31.25μg/mL in water extract and the lowest LC50 was 1345.86μg/mL in chloroform extract followed by water>ethyl acetate>hexane>butanol>methanol>chloroform extract.Similarly,different polarities of seed extracts,the highest LC50 against brine shrimp nauplii was shown to be 109.56μg/mL in butanol extract and the lowest LC50 was 1513.56μg/mL in ethyl acetate extract followed by butanol>hexane>water>methanol>chloroform>ethyl acetate extract.In conclusion,the results showed that both flowers and seeds extracts at various concentrations have promising potential against the positive and negative bacterial strains and the highest potential water extract could be used as natural broad-spectrum antibiotics as herbal medicine to treat different human infectious diseases. | Nuzha Bint Mahdi Bin Ali Al-Shukaili Mohammad Amzad Hossain | 2019 | Grain & Oil Science and Technology2019，2，4： | 2 |
| 7 | Chemical composition and anti-fungal properties of the essential oils and crude extracts of Orthosiphon stamineus Benth显示文摘 | M. Amzad Hossain Zhari Ismail Atiqur Rahman Sun Chul Kang | 2007 | Industrial Crops & Products2007，，3： | 1 |
| 8 | Antibacterial properties of essential oils and methanol extracts of sweet basil Ocimum basilicum occurring in Bangladesh显示文摘 | Amzad Hossain M Kabir M J Salehuddin S M | 2010 | Pharmaceutical Biology2010，48，5： | 1 |
| 9 | Chemical composition and anti-fungal properties of the essential oils and crude extracts of Orthosiphon stamineus Benth显示文摘 | M. Amzad Hossain Zhari Ismail Atiqur Rahman Sun Chul Kang | 2007 | Industrial Crops & Products2007，，3： | 1 |
| 10 | Polycyclic aromatic hydrocarbons(PAHs)in edible oils by gas chromatography coupled with mass spectroscopy显示文摘 | Amzad Hossain M Salehuddin S M | 2012 | Arabian Journal of Chemistry2012，5，3： | 1 |
| 11 | Evaluation of antioxidant and antimicrobial potential of different leaves crude extracts of Omani Ficus carica against food borne pathogenic bacteria显示文摘 | Afaf Mohammed Weli Afaf Ali Mohammed Al-Blushi Mohammad Amzad Hossain | 2015 | Asian Pacific Journal of Tropical Disease2015，，1： | 1 |
| 12 | Gas chromatography-mass spectrometry analysis of various organic extracts of Merremia borneensis from Sabah显示文摘Objective:To analyse the chemical composition of different extracts of Merremia borneensis(M. borneensis) by gas chromatography-mass spectrometry(GC-MS).Methods:The dried leaves powder was extracted with methanol at room temperature by using Soxhlet extractor.Methanol crude extracts of M.borneensis were extrastel with hexane,chloroform,ethyl acetate and butanol. Results:Qualitative analyses of various organic crude extracts showed that majority of these are flavonoids,terpeniods,alkaloids and glycosides.Most of the identified compounds by GCMS are biologically important.Further the M.borneensii leaf possesses certain characteristics that can be ascribed to cultivation on a domestic plantation.Conclusions:The suitable extracts for respective compounds can be chosen on the basis of above GC-MS analysis.All the major compounds from different extracts are biologically active molecules.Thus the identification of a good number of compounds from various extracts M.borneensis might have some ecological significance. | M Amzad Hossain Muhammad Dawood Shah Mahyar Sakari | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，8： | 1 |
| 13 | Total phenolics, flavonoids and antioxidant activity of tropical fruit pineapple显示文摘 | Amzad Hossain M Mizanur Rahman S M | | Food Research International0，201，44： | 1 |
| 14 | Polycyclic aromatic hydrocarbons (PAHs) in edi- ble oils by gas chromatography coupled with mass spectroscopy显示文摘 | AMZAD HOSSAIN M SALEHUDDIN S M | 2012 | Arabian Journal o{ Chem istry2012，5，3： | 1 |
| 15 | Total phenolics, flavonoids and antioxidant activity of tropical fruit pineapple 显示文摘 | Amzad Hossain M Mizanur Rahman S M | 2011 | Food Res Int2011，44，3： | 1 |
| 16 | Polycyclic aromatic hydrocarbons (PAHs) in edible oils by gas chromatography coupled with mass spectroscopy显示文摘 | Amzad H M Salehuddin S M | | 0，，14： | 1 |
| 17 | A new antimicrobial compound from the leaves of Dodonaea viscosa for infectious diseases显示文摘The main aim of this research work was to isolate and characterize the antimicrobial compounds that can be extracted from the leaves of Dodonaea viscosa(D.viscosa)and to assess their antimicrobial potency by established in-vitro agar diffusion method.The methanol extract was liquefied and fractioned by using a separatory funnel and organic solvents having different polarities.The agar diffusion technique was used to assess the antimicrobial potency of extracts and pure compounds against 5 g(+and-)microbial strains.Antimicrobial potency results showed that all extracts and isolated pure compounds provided significant antimicrobial potency against the applied microbial strains.The highest activity chloroform extract was analysed by column chromatography(CC)for the isolation of antimicrobial compounds.The structure of the isolated compounds was characterized based on 1D,2D NMR and MS spectra.In conclusion,purest compounds might be useful as a remedy for infectious diseases. | Basma Mubarak Hamed Al Bimani Mohammad Amzad Hossain | 2020 | Bioactive Materials2020，5，3： | 1 |
| 18 | Polycyclic aromatic hy- drocarbons (PAHs) in edible oils by gas chromatography coupled with mass spectroscopy显示文摘 | AMZAD HOSSAIN M SALEHUDDIN S M | 2012 | Arabian Journal of Chemistry2012，5，3： | 1 |
| 19 | Totalflavonoids content and biochemical screening of the leaves of tropical endemic medicinal plant Merremia borneensis显示文摘 | Muhammad Dawood Shah Amzad Hossain M | 2011 | Arabian Journal of Chemistry2011，，12： | 1 |
| 20 | Total phenolics,flavonoids contents and antioxidant activity of tropical medicinal plant Merremia borneensis显示文摘 | MUHAMMAD D S AMZAD H | 2010 | Arabian Journal of Chemistry2010，3，10： | 1 |
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