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4篇 您的检索式:作者名="Ana FURLAN"
    题名 作者 年代 出处 被引量
1The anthelmintic effect of plant extracts on Haemonchus contortus and Strongyloides venezuelensis显示文摘Camila O. Carvalho Ana Carolina S. Chagas Fernando Cotinguiba Maysa Furlan Luciana G. Brito Francisco C.M. Chaves Marília P. Stephan Humberto R. Bizzo Alessandro F.T. Amarante 2011Veterinary Parasitology2011,,3:1
2Tropical Isabella Grape Juices: Bioactive Compounds and Antioxidant Power Depends on Harvest Season显示文摘Cinthia Bau Betim Cazarin Luiz Claudio Correa Juliana Kelly da Silva Angela Giovana Batista Cibele Priscila Busch Furlan Aline Camarao Telles Biasoto Giuliano Elias Pereira Ana Cecilia Poloni Rybka Mairio Roberto Marostica Junior 2013Journal of Food Science and Engineering2013,3,2:0
3Insights into the Effect of a Natural Arsenate Dose on Growth,Nodulation and Redox Metabolism of Soybean Plants显示文摘Dear Editor, Arsenic (As) is a harmful metalloid that occurs in soil and water;its concentration varies considerably among geographic regions, with groundwater being the principal source of human contamination (Smedley and Kinniburgh, 2002). Besides the direct contamination effect of drinking water that contains high As concentration, human poisoning may also occur after ingestion of contaminated food.Eliana BIANUCCI Ana FURLAN Luis E.HERNáNDEZ Stella CASTRO 2019Pedosphere2019,29,4:0
4Purification,characterization and antiproliferative activity of L-asparaginase from Aspergillus oryzae CCT 3940 with no glutaminase activity显示文摘Objective:To explore the anti-proliferative activity of purified L-asparaginase from Aspergillus oryzae CCT 3940(A.oryzae).Methods:L-asparaginase was produced by submerged fermentation and purified to electrophoresis homogeneity by ionic exchanged chromatography in a fast protein liquid chromatographic system.The purified enzyme was characterized and used for the antiproliferative assay against nine tumor cell lines and one non-tumor cell line.Results:The free glutaminase L-asparaginase was purified 28.6 fold.L-asparaginase showed high stability under physiological condition,remaining stable in the p H range7.0–8.0 after 1 h incubation at temperature range 30–45℃.The Km and Vmax values of purified L-asparaginase were estimated as 0.66 mmol/L and 313 IU/mL,respectively.The purified enzyme could inhibit the growth of a broad range of human tumor cell lines at the concentrations studied.Also,the enzyme from A.oryzae CCT 3940 could inhibit tumor growth of leukemia cell line(K562) with a total growth inhibition value of(3.2 ± 2.5) IU/mL and did not inhibit the non-carcinogenic human cell line growth at the concentrations studied.Conclusions:The sensitivity of the cells lines to purified L-asparaginase from A.oryzae CCT 3940 appeared to be concentration dependent affording a more significant decrease in cell growth than that observed for the commercial L-asparaginase from Escherichia coli.The L-asparaginase from A.oryzae CCT 3940 has a high potential for pharmaceutical exploitation in the treatment of leukemia.Fernanda Furlan Goncalves Dias Ana Lucia Tasca Gois Ruiz Adriana Della Torre Helia Harumi Sato 2016Asian Pacific Journal of Tropical Biomedicine2016,6,9:0
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