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| 1 | Oral purgative and simethicone before small bowel capsule endoscopy显示文摘AIM:To evaluate small bowel cleansing quality,diagnostic yield and transit time,comparing three cleansing protocols prior to capsule endoscopy.METHODS:Sixty patients were prospectively enrolled and randomized to one of the following cleansing protocols:patients in Group A underwent a 24 h liquid diet and overnight fasting;patients in Group B followed protocol A and subsequently were administered 2 L of polyethylene glycol(PEG) the evening before the procedure;patients in Group C followed protocol B and were additionally administered 100 mg of simethicone 30 min prior to capsule ingestion.Small bowel cleansing was independently assessed by two experienced endoscopists and classified as poor,fair,good or excellent according to the proportion of small bowel mucosa under perfect conditions for visualization.When there was no agreement between the two endoscopists,the images were reviewed and discussed until a consensus was reached.The preparation was considered acceptable if > 50% or adequate if > 75% of the mucosa was in perfect cleansing condition.The amount of bubbles was assessed independently and it was considered significant if it prevented a correct interpretation of the images.Positive endoscopic findings,gastric emptying time(GET) and small bowel transit time(SBTT) were recorded for each examination.RESULTS:There was a trend favoring Group B in achieving an acceptable(including fair,good or excellent) level of cleansing(Group A:65%;Group B:83.3%;Group C:68.4%) [P = not significant(NS)] and favoring Group C in attaining an excellent level of cleansing(Group A:10%;Group B:16.7%;Group C:21.1%)(P = NS).The number of patients with an adequate cleansing of the small bowel,corresponding to an excellent or good classification,was 5(25%) in Group A,5(27.8%) in Group B and 4(21.1%) in Group C(P = 0.892).Conversely,7 patients(35%) in Group A,3 patients(16.7%) in Group B and 6 patients(31.6%) in Group C were considered to have poor small bowel cleansing(P = 0.417),with significant fluid or debris such that the examination was unreliable.The proportion of patients with a significant amount of bubbles was 50% in Group A,27.8% in Group B and 15.8% in Group C(P = 0.065).This was significantly lower in Group C when compared to Group A(P = 0.026).The mean GET was 27.8 min for Group A,27.2 min for Group B and 40.7 min for Group C(P = 0.381).The mean SBTT was 256.4 min for Group A,256.1 min for Group B and 258.1 min for Group C(P = 0.998).Regarding to the rate of complete examinations,the capsule reached the cecum in 20 patients(100%) in Group A,16 patients(88.9%) in Group B and 17 patients(89.5%) in Group C(P = 0.312).A definite diagnosis based on relevant small bowel endoscopic lesions was established in 60% of the patients in Group A(12 patients),44.4% in Group B(8 patients) and 57.8% in Group C(11 patients)(P = 0.587).CONCLUSION:Preparation with 2 L of PEG before small bowel capsule endoscopy(SBCE) may improve small bowel cleansing and the quality of visualization.Simethicone may further reduce intraluminal bubbles.No significant differences were found regarding GET,SBTT and the proportion of complete exploration or diagnostic yield among the three different cleansing protocols. | Bruno Joel Ferreira Rosa Mara Barbosa Joana Magalhes Ana Rebelo Maria Joo Moreira José Cotter | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，2： | 21 |
| 2 | Molecular mechanisms underlying the neuroprotection of environmental enrichment in Parkinson’s disease显示文摘Parkinson’s disease is the most common movement disorder,affecting about 1%of the population over the age of 60 years.Parkinson’s disease is characterized clinically by resting tremor,bradykinesia,rigidity and postural instability,as a result of the progressive loss of nigrostriatal dopaminergic neurons.In addition to this neuronal cell loss,Parkinson’s disease is characterized by the accumulation of intracellular protein aggregates,Lewy bodies and Lewy neurites,composed primarily of the proteinα-synuclein.Although it was first described almost 200 years ago,there are no disease-modifying drugs to treat patients with Parkinson’s disease.In addition to conventional therapies,non-pharmacological treatment strategies are under investigation in patients and animal models of neurodegenerative disorders.Among such strategies,environmental enrichment,comprising physical exercise,cognitive stimulus,and social interactions,has been assessed in preclinical models of Parkinson’s disease.Environmental enrichment can cause structural and functional changes in the brain and promote neurogenesis and dendritic growth by modifying gene expression,enhancing the expression of neurotrophic factors and modulating neurotransmission.In this review article,we focus on the current knowledge about the molecular mechanisms underlying environmental enrichment neuroprotection in Parkinson’s disease,highlighting its influence on the dopaminergic,cholinergic,glutamatergic and GABAergic systems,as well as the involvement of neurotrophic factors.We describe experimental pre-clinical data showing how environmental enrichment can act as a modulator in a neurochemical and behavioral context in different animal models of Parkinson’s disease,highlighting the potential of environmental enrichment as an additional strategy in the management and prevention of this complex disease. | Tamara Andrea Alarcón Sarah Martins Presti-Silva Ana Paula Toniato Simões Fabiola Mara Ribeiro Rita Gomes Wanderley Pires | 2023 | Neural Regeneration Research2023，18，7： | 2 |
| 3 | Struc- ture and cytotoxicity of new polyhydroxylated sterols from the Caribbean gorgonian Plexaurella grisea 显示文摘 | Ana Rueda Eva Zuh'a Mara J Orteg'a | 2001 | Steroids2001，66，： | 1 |
| 4 | Dietary corn germ containing pheytic acid prevents pork meat lipid oxidation while maintaining normal animal growth performance显示文摘 | Ana Paula R Harbach Mara C R da Costa | 2007 | Food Chemistry2007，100，： | 1 |
| 5 | Antiviral activity of seven iridoids three saikosaponins and one phenylpropanoid glycoside extracted from Bupleurum rigidum and Scrophularia scorodonia显示文摘 | aulina V Mara JA Ana MD | 2002 | Plant med2002，68，： | 1 |
| 6 | Antiviral activity of seven iridoids three saikosaponins and one phenylpropanoid glycoside extracted from Bupleurum rigidum and Scrophlaria scorodonia显示文摘 | anlina V Mara JA Ana MD | 2002 | Plant meal2002，68，： | 1 |
| 7 | CH IH - DFT determination of the molecular strticture, infrared and ultraviolet spectra of the flavonoid quercetin 显示文摘 | Ana Mara Daniel GM | 2004 | Journal of Molecular Structure: Theochem2004，681，3： | 1 |
| 8 | Genotoxic studies in hypertensive and normotensive rats treated with amiodarone显示文摘 | Mara Ribeiro Almeida Estela de Oliveira Lima Valdo José Dias da Silva Mateus Gandra Campos Lusania M.G. Antunes Ana Karina Dias Salman Francisca L. Dias | 2008 | MutRes-Genetic Toxicology and Environmental Mutagenesis2008，，2： | 1 |
| 9 | Antiviral activity of sev en iridoids three saikosaponins and one phenylpropanoid glyco side extracted from Bupleurum rigidum and Scrophularia scorodonia显示文摘 | Paulina V Mara JA Ana MD etal | 2002 | Plant med2002，68，： | 1 |
| 10 | Interactions between leaf water potential,stomatal conductance and abseisic acid content of orange trees submittad to drought stress显示文摘 | Mara de Menezes de Assis Gomes Ana Maria Magalhace Andrade Lagoa Camilo Lazaro Medina | 2004 | Braz J Plant Physiol2004，16，3： | 1 |
| 11 | Thermophysical Characterization of Ionic Liquids Able to Dissolve显示文摘 | Mara G F Ana R T Marisa A | 2011 | Journal of Chemical and Emgineering Data2011，56，12： | 1 |
| 12 | Clean synthesis of molecular recognition polymeric materials with chiral sensing capability using supercritical fluid technology. Application as HPLC stationary phases显示文摘 | Mara Soares da Silva Eva R. V?o Márcio Temtem Luís Mafra Jorge Caldeira Ana Aguiar-Ricardo Teresa Casimiro | 2009 | Biosensors and Bioelectronics2009，，7： | 1 |
| 13 | Sound Insulation of Floors: A New Composite with a Resilient Layer of Recycled Polymer显示文摘 | Aline Zini Leticia K. Zuchetto Maria Femanda de O. Nunes Ana M. C. Grisa Daniel T. Pagnussat Mara Zeni | 2016 | Journal of Civil Engineering and Architecture2016，10，8： | 0 |
| 14 | “三明治修复技术”和复合树脂修复非龋性牙颈部缺损的临床疗效评估:系统综述和Meta分析显示文摘研究目的:比较三明治修复技术(玻璃离子水门汀[GIC]或树脂改性玻璃离子水门汀[RMGIC]垫底,复合树脂[CR]充填)和仅用复合树脂充填修复非龋性牙颈部缺损(NCCLs)充填体的保留率。材料与方法:检索以下数据库:the Cochrane Library.PubMed,Scopus和Web of Science。同时检索了灰色文献和IADR正在进行和未发表的摘要(1990-2017)。应用Cochrane风险评估工具评估纳入文献质量。应用随机效应模型对随访1.2.3年的相关结果进行meta分析。应用GRADE法进行证据质量评价。结果:最初共检索到3645篇文献。经过对题目、摘要和全文进行筛选,共纳入6篇文献。其中有3篇文献是对同一随机临床试验的随访研究,所以最终对4项研究进行分析。4项研究均未报道偏倚风险程度。在所有结果中,仅在随访3年时应用三明治修复技术的充填体脱落率低于仅应用复合树脂充填(风险比[RR]:7.5.95%Cl:2.1-27.2:p=0.002)。结论:本系统综述纳入研究数量有限,随访3年时应用三明治修复技术的充填体保留率高于仅应用复合树脂充填。缺损修复方式不影响次要结果。除充填体保留率的质量等级为中等,其他次要结果的质量等级都为低。 | Alexandra Mara de Paula Thaynara Faelly Boing Leticia Maira Wambier Taise Alessandra Hanzen Alessandro D.Loguercio Ana Armas-Vega Alessandra Reis 李杰(译) 张珊珊(审) 郑树国(审) | 2020 | 中国口腔医学继续教育杂志2020，23，4： | 0 |
| 15 | Tailoring the partitioning of proteins using ionic liquids as adjuvants in polymer-polymer aqueous biphasic systems显示文摘Aqueous biphasic systems(ABS)are promising for proteins purification;however,when dealing with samples comprising several proteins,the selectivity towards a target protein is difficult to achieve.In this work,the addition of ionic liquids(ILs)as adjuvants(5 wt%and 10 wt%)in ABS composed of polyethylene glycol(PEG)and dextran was investigated to tailor proteins partitioning between the coexisting phases.The liquid-liquid phase diagrams were determined at 298 K,followed by partition studies of three proteins(bovine serum albumin(BSA),immunoglobulin G(IgG),and cytochrome C(Cyt C)).Partition coefficients of IgG and BSA indicate the preference of both proteins to the dextran-rich phase,whereas Cyt C has no preferential partitioning between the phases.The addition of chloride-based ILs as adjuvants allows to increase or decrease the partition coefficients,thus tailoring the proteins partitioning between the phases.BSA partitioning essentially depends on the IL content in each phase,whereas Cyt C and IgG partitioning is ruled by the ILs chemical structure and established interactions.Molecular docking was carried out to address the ILs effect on the proteins partitioning,supporting experimental observations,while identifying the specific interactions occurring.The partition of each protein in polymer-salt ABS with ILs as adjuvants was determined,demonstrating the higher tailoring ability of polymer-polymer ABS when adding ILs.Finally,the partition of each protein in presence of the remaining ones was determined,as well as the selectivity of the studied systems to separate each pair of proteins,paving the way for their use in liquidliquid chromatography. | Flavia F.Magalhaes Matheus M.Pereira Rita de Cassia Superbi de Sousa Ana P.M.Tavares Joao A.P.Coutinho Mara G.Freire | 2022 | Green Chemical Engineering2022，3，4： | 0 |
| 16 | Agglomerated Boards Evaluation with Waste of Polyurethane Skin and Non-halogenated Flame Retardants显示文摘 | Aguinaldo Oliveira Machado Jocelei Duarte Maria Fernanda de Oliveira Ana Maria Coulon Grisa Mara Zeni | 2018 | 材料科学与工程(中英文B版)2018，8，1： | 0 |
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