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| 1 | Evidence Supporting a Key Role of Lp-PLA2-Generated Lysophosphatidylcholine in Human Atherosclerotic Plaque Inflammation显示文摘 | Isabel Gon?alves Andreas Edsfeldt Na Young Ko Helena Grufman Katarina Berg Harry Bj?rkbacka Mihaela Nitulescu Ana Persson Marie Nilsson Cornelia Prehn Jerzy Adamski Jan Nilsson | 2012 | Arteriosclerosis, Thrombosis, and Vascular Biology2012，，6： | 1 |
| 2 | Arsenic exposure and prevalence of type 2 diabetes in US adults显示文摘 | ANA NA ELLEN KS ROBERTO PB | 2008 | JAMA2008，300，7： | 1 |
| 3 | Secretory Component显示文摘 | Armelle Phalipon Ana Cardona Jean-Pierre Kraehenbuhl Léna Edelman Philippe J. Sansonetti Blaise Corthésy | 2002 | Immunity2002，，1： | 1 |
| 4 | Dietary fibre from vegetable products as source of functional ingredients显示文摘 | ROCI' ORODRI' GUEZ ANA JIME' NEZ JUAN FER- NA' NDEZBOLAN | 2006 | Trends in Food Science & Technology2006，，17： | 1 |
| 5 | Complete Genome Sequence of Mycoplasma wenyonii Strain Massachusetts显示文摘 | Andrea P. dos Santos Ana M. S. Guimaraes Naíla C. do Nascimento Phillip J. SanMiguel Joanne B. Messick | 2012 | Journal of Bacteriology2012，，19： | 1 |
| 6 | Achieving CO2 Reductions in Colombia:Effects of Carbon Taxes and Abatement Targets显示文摘 | Silvia Calderóna Andrés Camilo Alvareza Ana María Loboguerrerob SantiagoArangoc Katherine Calvind Tom Kobere Kathryn Daenzerf Karen Fisher-Vandenf | 2015 | Energy Economics2015，，5： | 1 |
| 7 | Antibiotics in otorbinolaryngology L jilja- practice 显示文摘 | Stefan- Mikic San&a Sabo Ana Jovancevic na | 2010 | Medieinski pregled2010，，55： | 1 |
| 8 | Gene expression profiling of serrated polyps identifies annexin A10 as a marker of a sessile serrated adenoma/polyp显示文摘 | David Hernandez Gonzalo Keith K Lai Bonnie Shadrach John R Goldblum Ana E Bennett Erinn Downs‐Kelly Xiuli Liu Walter Henricks Deepa T Patil Paula Carver Jie Na Banu Gopalan Lisa Rybicki Rish K Pai | 2013 | J. Pathol2013，，4： | 1 |
| 9 | Serum selenium levels and all cause, cancer and cardiovascular mortality among US aduhs显示文摘 | Joachim B Ana NA Eliseo G | 2008 | Arch Inter Med2008，168，4： | 1 |
| 10 | A multivariate Kolmogorov-Smirnov test of goodness of fit显示文摘 | JUSTEL Ana PE NA Daniel ZAMAR Rubén | 1997 | Statistics & Probability Letters1997，35，： | 1 |
| 11 | Antibacterial activity and inhibition against Staphylococcus aureus NorA efflux pump by ferulic acid and its esterified derivatives显示文摘Objective:To evaluate the inhibitory activity of ferulic acid and four of its esterified derivatives(methyl,ethyl,propyl,and butyl)against resistance mechanisms in Staphylococcus aureus strains.Methods:Ferulic acid derivatives were obtained by esterification with methanol,ethanol,propanol,and butanol,and then characterized by hydrogen and carbon-13 nuclear magnetic resonance analysis.The minimum inhibitory concentrations(MIC)of ferulic acid and its esterified derivatives,ethidium bromide,and norfloxacin were obtained using the microdilution test,while the efflux pump inhibition test was conducted by examining reduction in the MICs of norfloxacin and ethidium bromide.Molecular docking was also carried out using the Schrodinger Suite 2015 molecular modeling software.A three-dimensional model of NorA efflux pump was generated using I-TASSER.The best scoring model was used as a receptor for ligand-receptor docking.Results:The methyl and butyl ester derivatives did not demonstrate significant antimicrobial activity.However,a significant synergic effect was evidenced when norfloxacin was combined with the ethyl and propyl esterified derivatives.The docking study demonstrated favorable energy of interaction between ferulate derivatives and NorA,and amino acid residues TYR57,TYR58,and LEU255 were present commonly in stabilizing all complexes.The PCA analysis corroborated the docking hypothesis that the lipophilic character and hydrogen bond interactions were the most relevant characteristics involved with NorA inhibitors.The pharmacokinetic parameters of ferulic acid derivatives showed good ADMET properties,demonstrating that they can be easily absorbed and have no effect or inhibit the cytochrome P450 enzyme complex,revealing their potential as drug candidates.Conclusions:This study provides strong evidence that the molecular basis for this activity is potentially due to the NorA efflux pump. | Patrícia Gonçalves Pinheiro Gilvandete Maria Pinheiro Santiago Francisco Erivaldo Freitas da Silva Ana Carolina Justino de Araújo Cícera Rejane Tavares de Oliveira Priscilla Ramos Freitas Janaína Esmeraldo Rocha JoséBezerra de Araújo Neto Maria Milene Costa da Silva Saulo Relison Tintino Irwin Rose Alencar de Menezes Henrique Douglas Melo Coutinho JoséGalberto Martins da Costa | 2021 | Asian Pacific Journal of Tropical Biomedicine2021，11，9： | 0 |
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