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您的检索式：作者名="Anantha NV"
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| 1 | Ivabradine in the treatment of systolic heart failure- A systematic review and meta-analysis显示文摘AIM To perform a systematic-review and meta-analysis to compare outcomes of ivabradine combined with betablocker to beta-blocker alone in heart failure with reduced ejection fraction(HFr EF).METHODS We searched PubM ed, Cochrane, EMBASE, CINAHL and Web of Science for trials comparing ivabradine + betablocker to beta-blocker alone in HFr EF. We performed a systematic-review and meta-analysis of published literature. Primary end-point was combined end point of cardiac death and hospitalization for heart failure.RESULTS Six studies with 17671 patients were included. Mean follow-up was 8.7 ± 7.9 mo. Combined end-point of heart failure readmission and cardiovascular death was better in ivabradine + beta-blocker group compared to beta-blocker alone(RR: 0.93, 95%CI: 0.79-1.09, P = 0.354). Mean difference(MD) in heart rate was higher in the ivabradine + beta-blocker group(MD: 6.14, 95%CI: 3.80-8.48, P < 0.001). There was no difference in all cause mortality(RR: 0.98, 95%CI: 0.89-1.07, P = 0.609), cardiovascular mortality(RR: 0.99, 95%CI: 0.86-1.15, P = 0.908) or heart failure hospitalization(RR: 0.87, 95%CI: 0.68-1.11, P = 0.271). CONCLUSION From the available clinical trials, ivabradine + betablocker resulted in a significantly greater reduction in HRcoupled with improvement in combined end-point of heart failure readmission and cardiovascular death but with no improvement in all cause or cardiovascular mortality. Given the limited evidence, further randomized controlled trials are essential before widespread clinical application of ivabradine + beta-blocker is advocated for HFrEF. | Mahesh Anantha Narayanan Yogesh NV Reddy Janani Baskaran Abhishek Deshmukh David G Benditt Ganesh Raveendran | 2017 | World Journal of Cardiology2017，9，2： | 5 |
| 2 | Porphyrin binding to qua- drupled T4G4显示文摘 | Anantha NV Azam M Sheardy RD | 1998 | Biochemistry1998，37，9： | 1 |
| 3 | Porphyrin binding to quadruplexed T4G4显示文摘 | Anantha NV Azam M Sheardy RD | 1998 | Biochemistry1998，37，： | 1 |
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