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| 1 | Second-look surgery plus hyperthermic intraperitoneal chemotherapy for patients with colorectal cancer at high risk of peritoneal carcinomatosis:Does it really save lives?显示文摘The treatment of peritoneal carcinomatosis (PC) of colorectal origin with cytoreductive surgery(CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) has a 5-year recurrence-free or cure rate of at least 16%, so it is no longer labeled as a fatal disease, and offers prolonged survival for patients with a low peritoneal carcinomatosis index. Metachronous PC of colorectal origin is so predictable that there is a model which has been used to successfully determine the individual risk of each patient. Patients at risk are clearly identified; those with the highest risk have small peritoneal nodules present in the first surgery (70% probability of developing PC), ovarian metastases(60%), perforated tumor onset or intraoperative tumor rupture(50%). Current clinical, biological and imaging techniques still lack sufficient sensitivity to diagnose PC in its initial stages, when CRS plus HIPEC has a greater impact and a higher cure rate. Second-look surgery with HIPEC or prophylactic HIPEC at the time of the first intervention have been proposed as means of preventing and/or anticipating clinical or radiological relapse in at-risk patients. Both techniques have shown a significant decrease in peritoneal relapses and should be considered essential weapons in the management of colorectal cancer. | Delia Cortes-Guiral Dominique Elias Pedro Antonio Cascales-Campos Alfredo Badía Yébenes Ismael Guijo Castellano Ana Isabel León Carbonero JoséIgnacio Martín Valadés Jesus Garcia-Foncillas Damian Garcia-Olmo | 2017 | World Journal of Gastroenterology2017，23，3： | 3 |
| 2 | Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation显示文摘 | Jose A. Rodríguez-Navarro Laura Rodríguez María J. Casarejos Rosa M. Solano Ana Gómez Juan Perucho Ana María Cuervo Justo García de Yébenes María A. Mena | 2010 | Neurobiology of Disease2010，，3： | 2 |
| 3 | Thalidomide for patients with recurrent lymphoma显示文摘 | Barbara P Anas Y Maher A | 2004 | Cancer2004，100，： | 1 |
| 4 | Poly(butylene terephthalate)/organo clay nanocomposites prepared by in-situ interlayer polymerization and its fiber (Ⅱ)显示文摘 | Chang J H Ana Y U Kim S J | 2003 | Polymer2003，44，19： | 1 |
| 5 | Communication beliefs about youth and old age in Asia and Canada显示文摘 | Ryan E Jin Y Anas A | | 0，，04： | 1 |
| 6 | Anesthesia with Isoflurane Increases Amyloid Pathology in Mice Models of Alzheimer’S Disease显示文摘 | Juan Perucho Isabel Rubio Maria J. Casarejos Ana Gomez Jose A. Rodriguez-Navarro Rosa M. Solano Justo Garcia De Yébenes Maria A. Mena | 2010 | Journal of Alzheimer’s Disease2010，，4： | 1 |
| 7 | Involvement of microRNA lethal-7a in the regulation of embryo implantation in mice显示文摘 | LIU Wei-min Ronald T K Pang Ana W Y Cheong | 2012 | PLoS One2012，7，37： | 1 |
| 8 | Microcrystalline cellulose from soybean husk: Effects of solvent treatments on its properties as acetylsalicylic acid carrier显示文摘 | Nelson Y U Edgardo A G Ana A W | 2000 | International Journal of Pharmaceutics2000，206，12： | 1 |
| 9 | Thalidomide for patients with recurrent|ymphoma显示文摘 | Barbear P Anas Y Maher A el al | 2004 | Cancer2004，100，： | 1 |
| 10 | Modification of the surface properties of an activated carbon by oxygen plasma treatment显示文摘 | GARC(I)A Ana MART(I)NEZ-ALONSO Amelia LEON Carlos Leon Y | 1998 | Fuel1998，77，6： | 1 |
| 11 | Establishment and properties of a growth factor-dependent,perpetual neural stem cell line from the human CNS显示文摘 | Ana Villa Evan Y Snyder Angelo I Vescovi | 2000 | Exp Neurol2000，161，1： | 1 |
| 12 | 显示文摘 | Nelson Y U Edgardo A G Ana A W | 2000 | Inter J Pharmaceutics2000，206，： | 1 |
| 13 | A regional economy, land use, and transportation model (Relu-Tran?): formula- tion, algorithm design, and testing显示文摘 | ANAS A LIU Y | 2007 | Journal of Regional Science2007，47，3： | 1 |
| 14 | Lipase-catalyzed production of biodiesel fuel from vegetable oils contained in waste activated bleaching earth 显示文摘 | ANA V LARA P ENOCH Y P | 2003 | Process Biochemistry2003，，38： | 1 |
| 15 | Eu3 + and Tm3 + doped yttrium oxide thin films for optical applications 显示文摘 | Moll Y O P Huignard A Autic-Fidancev E Aschehoug P Vi- ana B Millon E | 2000 | Journal of Luminescence2000，8789，： | 1 |
| 16 | Temporal irrigation performance assessment in Turkey: Menemen case study显示文摘 | Kukul Y S Akcay S Ana S E | 2008 | Agricultural Water Management2008，，95： | 1 |
| 17 | Erythrocyte invasion by Babesia boris merozoites is inhibited by polyclonal antisera directed against peptides derived from a homologue of Plasmodium falciparum apical membrane antigen 显示文摘 | FASILA R G ANA P Y FRITS F J | 2004 | Infect Immun2004，72，5： | 1 |
| 18 | Glutathione re-ductase activity and isoforms in leaves and roots of wheatplants subjected to cadmium stress显示文摘 | GustavoG Y Ana J F A Diego M St | 2007 | Phytochemistry2007，，68： | 1 |
| 19 | Integration of self organizing feature maps neural network and genetic K-means algorithm for market segmentation 显示文摘 | KUO R J ANA Y L WANG H S | 2006 | Expert Syst Appl2006，30，2： | 1 |
| 20 | Eftecliveness of twosided UV- C treatments in inhibiting natural microflora and extcnding the shelf-life of minimally processed ' Red Oak Leaf' lettuce 显示文摘 | Ana A James L M Luo Y G et a} | 2006 | Food Microbidogy2006，23，： | 1 |
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