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	题名	作者	年代	出处	被引量
1	Impaired contractility and remodeling of the upper gastrointestinal tract in diabetes mellitus type-1显示文摘AIM: To investigate that both the neuronal function of the contractile system and structural apparatus of the gastrointestinal tract are affected in patients with longstanding diabetes and auto mic neuropathy. METHODS: The evoked esophageal and duodenal contractile activity to standardized bag distension was assessed using a specialized ultrasound-based probe. Twelve type-1 diabetic patients with autonomic neuropathy and severe gastrointestinal symptoms and 12 healthy controls were studied. The geometry and biomechanical parameters (strain, tension/stress, and stiffness) were assessed. RESULTS: The diabetic patients had increased frequency of distension-induced contractions (6.0 ± 0.6 vs 3.3 ± 0.5, P < 0.001). This increased reactivity was correlated with the duration of the disease (P = 0.009). Impaired coordination of the contractile activity in diabetic patients was demonstrated as imbalance between the time required to evoke the first contraction at the distension site and proximal to it (1.5 ± 0.6 vs 0.5 ± 0.1, P = 0.03). The esophageal wall and especially the mucosa-submucosa layer had increased thickness in the patients (P < 0.001), and the longitudinal and radial compressive stretch was less in diabetics (P <0.001). The esophageal and duodenal wall stiffness and circumferential deformation induced by the distensions were not affected in the patients (all P > 0.14). CONCLUSION: The impaired contractile activity with an imbalance in the distension-induced contractions likely reflects neuronal abnormalities due to autonomic neuropathy. However, structural changes and remodeling of the gastrointestinal tract are also evident and may add to the neuronal changes. This may contribute to the pathophysiology of diabetic gut dysfunction and impact on future management of diabetic patients with gastrointestinal symptoms.	Jens BrΦndum FrΦkjΦr SΦren Due Andersen Niels EjskjΦr Peter Funch-Jensen AsbjΦrn Mohr Drewes Hans Gregersen	2007	World Journal of Gastroenterology2007，13，36：	8
2	Additive effect of ACE inhibition and angiotensin Ⅱ receptor blockade in type Ⅰ diabetic patients with diabetic nephropathy显示文摘	Jacobsen P Andersen S Jensen BR	2003	J Am Soc Nephro12003，14，4：	1
3	Association of beta-adren-ergic receptor polymorphisms and mortality in carvedilol-treated chronicheart-failure patients显示文摘	Petersen M Andersen JT Hjelvang BR	2011	Br J Clin Pharmacol2011，71，4：	1
4	Antibiotics versus pla-cebo for prevention of postoperative infection after appendicectomy显示文摘	Andersen BR Kallehave FL Andersen HK	2005	Cochrane Database Syst Re2005，3，：	1
5	Association of betaadrenergic receptor polymorphisms and mortality in carvedilol-treated chronic heart-failure patients显示文摘	Petersen M Andersen JT Hjelvang BR	2011	Br J Clin Pharmacol2011，71，4：	1
6	Heparins and mechanical methods for thromboprophylaxis in colorectal surgery 显示文摘	Wille-JCrgensen P Rasmussen MS Andersen BR	2003	Cochrane Database Syst Rev2003，，00：	1
7	Additive ellect of ACE inhihition and angiotensin II receptor blockade in type1 diabetic patients with diabetic nepHropathy显示文摘	Jacobsen P Andersen S Jensen BR	2003	J Am Soc NepHrol2003，14，4：	1
8	Additive effect of ACE inhibition and angiotensin II receptor blockade in type I diabetic patients with diabetic nephropathy显示文摘	Jacobsen P Andersen S Jensen BR	2003	Journal of the American Society of Nephrology2003，14，4：	1
9	Association of GNASlpolymorphisms and mortality in calwedilol-treated chronicheart-failure patients 显示文摘	Petersen M Andersen JT Hjelvang BR	2013	Br J Clin Pharmacol2013，71，4：	1
10	Additive effect of ACE inhibition and angiotensin II receptor blockade in type I diabetic patients with diabetic nephropathy显示文摘	Jacobsen P Andersen S Jensen BR	2003	J Am Soc Nephrol2003，14，4：	1
11	Additive ellect of ACE in- hihition and angiotensin Ⅱ receptor blockade in type 1 diabetic pa- tients with diabetic nepHropathy显示文摘	Jacobsen P Andersen S Jensen BR	2003	J Am Soc NepHrol2003，14，4：	1
12	Prevalence of polyhydramnios at a Danish hospital-a population-based study显示文摘	Bundgaard A Andersen BR Rode L	2007	Acta Obstet Gynecol Scand2007，86，12：	1
13	Degree of hypother- mia in aortic arch surgery-optimal temperature for cerebral and spi- nal protection: deep hypothermia remains the gold standard in the absence of randomized data 显示文摘	Englum BR Andersen ND Husain AM	2013	Ann Cardiothorac Surg2013，2，2：	1
14	Results of therapy in systemic nocardiosis显示文摘	Geiseler PJ Andersen BR	1979	Am J Med Sci1979，278，：	1
15	Stimulation of the amygdaloid nuclear complex in unanesthetized cats显示文摘	Kaada BR Andersen P Jansen J	1954	Neurology (minneap)1954，4，：	1
16	Key site variables governing the functional characteristics of Dissolved Natural Organic Matter (DNOM) in Nordic forested catchments显示文摘	Rolf D. Vogt Jarkko Akkanen Dag Olav Andersen Rainer Brüggemann Bimal Chatterjee Egil Gjessing Jussi V. K. Kukkonen H?kon E. Larsen J?rg Luster Andrea Paul Stephan Pflugmacher Mike Starr Christian E. W. Steinberg Philippe Schmitt-Kopplin ádám Zsolnay	2004	Aquatic Sciences2004，，2：	1
17	Sustained low-dosegrowth hormone therapy optimizes bioactive insulin-like growth fac-tor-I level and May enhance CD4 T-cell number in HIV infection显示文摘	Andersen 0 Hansen BR Troensegaard W e? al	2010	Med Virol2010，82，2：	1
18	Genomic and genetic characterization of cholangiocarcin0ma identifies therapeutic tar- gets for tyrosine kinase inhibito~ 显示文摘	Andersen JB Spee B Blechacz BR	2012	Gastroenterology2012，142，4：	1
19	Additive effect of ACE inhibition and angiotensin Ⅱ receptor blockade in type Ⅰ diabetic patients with diabetic nephropathy 显示文摘	Jacobsen P Andersen S Jensen BR	2003	J Am So cNephrol2003，14，：	1
20	Heparins and mechanical methods for thromboprophylaxis in colorectal sur- gery 显示文摘	Wille-Jcrgensen P Rasmussen MS Andersen BR	2003	Cochrane Database $yst Rev2003，4，2：	1

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