|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Functional magnetic resonance imaging identifies abnormal visual cortical function in patients with occipital lobe epilepsy显示文摘 | Masuoka LK Anderson AW Gore JC | 1999 | Epilepsia1999，40，： | 1 |
| 3 | Quantifying serum antiplague antibody with a fiber-optic biosensor 显示文摘 | King KD Cao LK | 1998 | Clin Diagn Lab Immunol1998，5，5： | 1 |
| 4 | Consensus guidelines for delineation of clinical target volume for intensity- modulated pelvic radiotherapy in postoperative treatment of endometrial and cervical cancer显示文摘 | Small W Jr Mell LK Anderson P | 2008 | Int J Radiat Oncol Biol Phys2008，71，2： | 1 |
| 5 | Detection of Yersinia pestis fraction 1 antigen with a fiber optic biosensor显示文摘 | Cao LK Anderson GP Ligler FS | 1995 | J Clin Microbiol1995，33，2： | 1 |
| 6 | Detection of Yersinia pestis fraction 1 antigen with a fiber optic biosensor 显示文摘 | Anderson GP Ligler FS | 1995 | J Clin Microbiol1995，33，2： | 1 |
| 7 | Anaphylactic reaction during anaesthesia associated with positive intradermal skin test to fentanyl显示文摘 | Bennett MJ Anderson LK McMillanJC | 1986 | Can Anaesth SocJ1986，33，： | 1 |
| 8 | Methodological is- sues in cohort studies that relate sodium intake to cardiovas-ular disease outcomes: a science advisory from the American Heart Association 显示文摘 | Cobb LK Anderson CA Elliott P | 2014 | Circulation2014，129，10： | 1 |
| 9 | Consensus guidelines for delineation of clinical target volume for intensity modulated pelvic radiotherapy in postoperative treatment of endometrial and cervical cancer显示文摘 | Small W Jr Mell LK Anderson P | | 0，，： | 1 |
| 10 | Consensus guidelines for delineation of clinical target volume for intensity-modulated pelvic radiotherapy in postoperative treatment of endometrial and cervical cancer 显示文摘 | Small W Jr Mell LK Anderson P | 2008 | Int J Radiat Oncol Biol Phys2008，71，： | 1 |
| 11 | Consensus guidelines for delineation of clinical target volume for intensity-modulated pelvic radiotherapy in postoperative treatment of endometrial and cervicalcancer显示文摘 | Small W Jr Mell LK Anderson P | | 0，，02： | 1 |
| 12 | Consensus guidelines for delineation of clinical target volume for intensity-modulated pelvic radiotherapy in postoperative treatment of endometrial and cervical cancer显示文摘 | Small W Jr Mell LK Anderson P | 2008 | Int J Radiat Oncol Biol Phys2008，71，2： | 1 |
| 13 | Psychiatric morbidity and health outcome in type 1 dialetes-perspectives from a prospec- tive lonltudlnal study显示文摘 | Northam EA Matthews LK Anderson P J | 2004 | Diabetes Med2004，22，： | 1 |
| 14 | Retinal nerve fiber structure versus visual fieldfunction in patients with ischemic optic neuropathy 显示文摘 | Hood DC Anderson S Rouleau J Wenick AS Grover LK Beh-rens MM ef al | 2008 | Oph-thalmology2008，115，5： | 1 |
| 15 | Canonical Wnt/β-catenin signaling drives human schwann cell transformation,progression,and tumor maintenance显示文摘 | Watson AL Rahrmann EP Moriarity BS Choi K Conboy CB Greeley AD Halfond AL Anderson LK Wahl BR Keng VW Rizzardi AE Forster CL Collins MH Sarver A Wallace MR Schmechel SC Ratner N Largaespada DA | | 0，，06： | 1 |
| 16 | Consensus guidelines for delineation of clinical target volume for intensity-modulated pelvic radiotherapy in postoperative treatment of endometrial and cervical cancer显示文摘 | Small W Jr Mell LK Anderson P | 2008 | Int J Radiat Oncol Biol Phys2008，71，2： | 1 |
| 17 | Detection of Yersinia pestis fraction 1 antigen with a fiber optic biosensor 显示文摘 | Cao LK Anderson GP Ligler FS Ezzell J | 1995 | Clinical Microbio1995，33，2： | 1 |
| 18 | Consensus guidelines for delineation of clinical target volume for Intensity-modulated pelvic radiotherapy in postoperative treatment of endometrial and cervical cancer显示文摘 | Small WJr Mell LK Anderson P | 2008 | In J Radiat Oncol Gy Biol Phys2008，71，2： | 1 |
| 19 | Increasing muscle strength as a treatment for strabismus: sustained release of insulin-like growth factor-1 in rabbit extraocular muscle 显示文摘 | Mcloon LK Anderson BC Christiansen SP | 2006 | J AAPOS2006，10，5： | 1 |
| 20 | Detect of Yersinia Pestis fraction 1 antigen with a fiber optic biosensor显示文摘 | Gao LK Anderson GP Ligler FS | 1995 | J Clin Microbiol1995，33，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员