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| 1 | Epidural anesthesia improves pancreatic perfusion and decreases the severity of acute pancreatitis显示文摘AIM: To study the safety of epidural anesthesia(EA),its effect on pancreatic perfusion and the outcome of patients with acute pancreatitis(AP).METHODS: From 2005 to August 2010,patients with predicted severe AP [Ranson score ≥ 2,C-reactive protein > 100 or necrosis on computed tomography(CT)] were prospectively randomized to either a group receiving EA or a control group treated by patientcontrolled intravenous analgesia. Pain management was evaluated in the two groups every eight hours using the visual analog pain scale(VAS). Parameters for clinical severity such as length of hospital stay,use of antibiotics,admission to the intensive care unit,radiological/clinical complications and the need for surgical necrosectomy including biochemical data were recorded. A CT scan using a perfusion protocol was performed on admission and at 72 h to evaluate pancreatic blood flow. A significant variation in blood flow was defined as a 20% difference in pancreatic perfusion between admission and 72 h and was measured in the head,body and tail of the pancreas.RESULTS: We enrolled 35 patients. Thirteen were randomized to the EA group and 22 to the control group. There were no differences in demographic characteristics between the two groups. The Balthazar radiological severity score on admission was higher in the EA group than in the control group(mean score 4.15 ± 2.54 vs 3.38 ± 1.75,respectively,P = 0.347) and the median Ranson scores were 3.4 and 2.7 respectively(P = NS). The median duration of EA was 5.7 d,and no complications of the epidural procedure were reported. An improvement in perfusion of the pancreas was observed in 13/30(43%) of measurements in the EA group vs 2/27(7%) in the control group(P = 0.0025). Necrosectomy was performed in 1/13 patients in the EA group vs 4/22 patients in the control group(P = 0.63). The VAS improved during the first ten days in the EA group compared to the control group(0.2 vs 2.33,P = 0.034 at 10 d). Length of stay and mortality were not statistically different between the 2 groups(26 d vs 30 d,P = 0.65,and 0% for both respectively).CONCLUSION: Our study demonstrates that EA increases arterial perfusion of the pancreas and improves the clinical outcome of patients with AP. | Samira M Sadowski Axel Andres Philippe Morel Eduardo Schiffer Jean-Louis Frossard Alexandra Platon Pierre-Alexandre Poletti Leo Bühler | 2015 | World Journal of Gastroenterology2015，21，43： | 21 |
| 2 | Management of hepatocellular adenoma: Solitary-uncomplicated, multiple and ruptured tumors显示文摘AIM: While hepatocellular adenomas (Has) have often been studied as a unique entity, we aimed to better define current management of the various forms of Has.METHODS: Twenty-five consecutive patients operated for solitary-uncomplicated (9), multiple (6), and ruptured (10)Has were reviewed according to management strategies and outcomes.RESULTS: All solitary-uncomplicated Has (ranged 2.2-14 cm in size) were removed. Out of 25 Has, 2 (8%) included foci of carcinoma. In the multiple HA group, previously undiagnosed tumors were identified during surgery in 5/6cases. In three cases with multiple spread HA, several lesions had to be left unresected. They remained unmodified after 4-, 6-, and 6-year radiological follow-up. Patients with ruptured HA (ranged 1.7-10 cm in size) were initially managed with hemodynamic support and angiography,allowing the embolization of actively bleeding tumors in two patients. All ruptured tumors were subsequently removed 5.5 d (range 4-70 d) after admission. CONCLUSION: Tumors suspected of HA, regardless of the size, should be resected, because of high chances of rupture causing bleeding, and/or containing malignant foci.Although it is desirable to remove all lesions of multiple HA, this may not be possible in some patients, for whom long-term radiological follow-up is advised. Ruptured HA can be managed by hemodynamic support and angiography,allowing scheduled surgery. | Christian Toso Pietro Majno Axel Andres Laura Rubbia-Brandt Thierry Berney Leo Buhler Philippe Morel Gilles Mentha | 2005 | World Journal of Gastroenterology2005，11，36： | 9 |
| 3 | A Score Predicting Survival After Liver Retransplantation for Hepatitis C Virus Cirrhosis显示文摘 | Axel Andres Eric Gerstel Christophe Combescure Sonal Asthana Shaheed Merani Pietro Majno Thierry Berney Philippe Morel Norman Kneteman Gilles Mentha Christian Toso | 2012 | Transplantation2012，，7： | 3 |
| 4 | Light attenuation and scattering by phytoplanktonic cells: a theoretical modeling 显示文摘 | Annick Bricaud Andre Morel | 1986 | Appl Opt1986，25，4： | 1 |
| 5 | Modeling the inherent optical properties of the ocean based on the detailed composition of the planktonic community 显示文摘 | Dariusz Stramski Annick Bricaud Andre Morel | 2001 | Appl Opt2001，40，18： | 1 |
| 6 | Variability in the chlorophyll-specific absorption coefficients of natural phytoplankton : analysis and parameterization 显示文摘 | Bricaud Annick Babin Marcel Morel Andre | 1995 | Journal of Geophysical Research1995，100，13： | 1 |
| 7 | Examining the consistency of products derived from various ocean color sensors in open ocean (Case 1) waters in the perspective of a multi-sensor approach显示文摘 | André Morel Yannick Huot Bernard Gentili P. Jeremy Werdell Stanford B. Hooker Bryan A. Franz | 2007 | Remote Sensing of Environment2007，，1： | 1 |
| 8 | Phylogenetic disparity influences the predominance of direct over indirect pathway of antigen presentation in islet xenotransplantation显示文摘 | Andres A Toso C Morel P | 2005 | Transplantation Proceedings2005，37，1： | 1 |
| 9 | Involvement of Nrf2 activation in resistance to 5-fluorouracil in human colon cancer HT-29 cells显示文摘 | Hanane Akhdar Pascal Loyer Claudine Rauch Anne Corlu André Guillouzo Fabrice Morel | 2009 | European Journal of Cancer2009，，： | 1 |
| 10 | Importance of Inflammation and Neurohumoral Activation in Takotsubo Cardiomyopathy显示文摘 | Olivier Morel Frédérique Sauer Alessio Imperiale Sébastien Cimarelli Cyrille Blondet Laurence Jesel Annie Trinh Fabien De Poli Patrick Ohlmann André Constantinesco Pierre Bareiss | 2009 | Journal of Cardiac Failure2009，，3： | 1 |
| 11 | Transient left ventricular dysfunction syndrome: Patho-physiological bases through nuclear medicine imaging显示文摘 | Sébastien Cimarelli Frédérique Sauer Olivier Morel Patrick Ohlmann André Constantinesco Alessio Imperiale | | International Journal of Cardiology0，，： | 1 |
| 12 | Chlorophyll-specific scattering coefficient of phytoplankton:a simplified theoretical approath显示文摘 | MOREL Andre | 1987 | Deep-Sea Research1987，34，7： | 1 |
| 13 | Treatment strategies for the management of advanced colorectal liver metastases detected synchronously with the primary tumour显示文摘 | G. Mentha P. Majno S. Terraz L. Rubbia-Brandt P. Gervaz A. Andres A.S. Allal Ph. Morel A.D. Roth | 2007 | European Journal of Surgical Oncology2007，，： | 1 |
| 14 | Human Pharmacokinetics and Safety Evaluation of SonoVue?, a New Contrast Agent for Ultrasound Imaging显示文摘 | DENIS R. MOREL IAN SCHWIEGER LAURENT HOHN JACQUES TERRETTAZ JEAN BERNARD LLULL YVES ANDRé CORNIOLEY MICHEL SCHNEIDER | 2000 | Investigative Radiology2000，，1： | 1 |
| 15 | Variability in the chlorophyll-specific absorption coefficients of natural phytoplankton:analysis and parameterization显示文摘 | BRICAUD Annick BABIN Marcel MOREL Andre | 1995 | Journal of Geophysical Research1995，100，13： | 1 |
| 16 | Variations of light absorption by suspended particles with chlorophyll a concentration in oceanic (Case 1) waters:analysis and implications for bio-optical models显示文摘 | BRICAUD Annick MOREL Andre BABIN Marcel | 1998 | Journal of Geophysical Research1998，103，31： | 1 |
| 17 | Apparent optical properties of oceanic water: dependence on the molecular scattering contribution 显示文摘 | Andre Morel Hubert Loisel | 1998 | ApplOpt1998，37，21： | 1 |
| 18 | Systematic review and meta‐analysis of fibrin sealants for patients undergoing pancreatic resection显示文摘 | Lorenzo A. Orci Graziano Oldani Thierry Berney Axel Andres Gilles Mentha Philippe Morel Christian Toso | 2014 | HPB2014，，1： | 1 |
| 19 | Impairment of renal function after islet transplant alone or islet-after-kidney transplantation using a sirolimus/tacrolimus-based immunosuppressive regimen 显示文摘 | Andres A Toso C Morel P | 2005 | Transpl Int2005，18，11： | 1 |
| 20 | Study of wheat gluten plasticization with fatty acids 显示文摘 | Marion Pommet Andréas Redl Marie-Hélène Morel | 2003 | Polymer2003，44，： | 1 |
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